Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Marian J.) > Genome-wide Associa...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		08150naa a2201633 4500
001		oai:DiVA.org:umu-169391
003		SwePub
008		200401s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:11710ffd-da84-4326-be0b-382b4af208ad
009		oai:prod.swepub.kib.ki.se:143190360
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1693912 URI
024	7	a https://doi.org/10.1016/j.ajhg.2020.02.0062 DOI
024	7	a https://lup.lub.lu.se/record/11710ffd-da84-4326-be0b-382b4af208ad2 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1431903602 URI
040		a (SwePub)umud (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Li, Chenu University of Cambridge,Glenfield Hospital4 aut
245	1 0	a Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
264	1	b CELL PRESS,c 2020
338		a electronic2 rdacarrier
520		a Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1 , PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a telomere length
653		a biological aging
653		a Mendelian randomisation
653		a age-related disease
653		a age-related disease
653		a biological aging
653		a Mendelian randomisation
653		a telomere length
700	1	a Stoma, Svetlanau Karolinska Institutet4 aut
700	1	a Lotta, Luca A.4 aut
700	1	a Warner, Sophie4 aut
700	1	a Albrecht, Eva4 aut
700	1	a Allione, Alessandra4 aut
700	1	a Arp, Pascal P.4 aut
700	1	a Broer, Linda4 aut
700	1	a Buxton, Jessica L.4 aut
700	1	a Da Silva Couto Alves, Alexessander4 aut
700	1	a Deelen, Joris4 aut
700	1	a Fedko, Iryna O.4 aut
700	1	a Gordon, Scott D.4 aut
700	1	a Jiang, Tao4 aut
700	1	a Karlsson, Robertu Karolinska Institutet4 aut
700	1	a Kerrison, Nicola4 aut
700	1	a Loe, Taylor K.4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Milaneschi, Yuri4 aut
700	1	a Miraglio, Benjamin4 aut
700	1	a Pervjakova, Natalia4 aut
700	1	a Russo, Alessia4 aut
700	1	a Surakka, Ida4 aut
700	1	a van der Spek, Ashley4 aut
700	1	a Verhoeven, Josine E.4 aut
700	1	a Amin, Najaf4 aut
700	1	a Beekman, Marian4 aut
700	1	a Blakemore, Alexandra I.4 aut
700	1	a Canzian, Federico4 aut
700	1	a Hamby, Stephen E.4 aut
700	1	a Hottenga, Jouke-Jan4 aut
700	1	a Jones, Peter D.4 aut
700	1	a Jousilahti, Pekka4 aut
700	1	a Mägi, Reedik4 aut
700	1	a Medland, Sarah E.4 aut
700	1	a Montgomery, Grant W.4 aut
700	1	a Nyholt, Dale R.4 aut
700	1	a Perola, Markusu University of Helsinki,Finnish National Institute for Health and Welfare4 aut0 (Swepub:lu)med-mkp
700	1	a Pietiläinen, Kirsi H.4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Sillanpää, Elina4 aut
700	1	a Suchiman, H. Eka4 aut
700	1	a van Heemst, Diana4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Agudo, Antonio4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Boomsma, Dorret I.4 aut
700	1	a Chirlaque, Maria-Dolores4 aut
700	1	a Fagherazzi, Guy4 aut
700	1	a Ferrari, Pietro4 aut
700	1	a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, 20502 Malmö Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
700	1	a Gieger, Christian4 aut
700	1	a Eriksson, Johan Gunnaru Helsinki University Central Hospital,University of Helsinki,National University of Singapore4 aut0 (Swepub:lu)med-jeo
700	1	a Gunter, Marc4 aut
700	1	a Hagg, Sara4 aut
700	1	a Hovatta, Iiris4 aut
700	1	a Imaz, Liher4 aut
700	1	a Kaprio, Jaakko4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Key, Timothy4 aut
700	1	a Krogh, Vittorio4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Metspalu, Andres4 aut
700	1	a Moreno, Concha4 aut
700	1	a Onland-Moret, N. Charlotte4 aut
700	1	a Nilsson, Peteru Skåne University Hospital4 aut0 (Swepub:lu)medf-pni
700	1	a Ong, Ken K.4 aut
700	1	a Overvad, Kim4 aut
700	1	a Palli, Domenico4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Pedersen, Nancy L.u Karolinska Institutet4 aut
700	1	a Penninx, Brenda W. J. H.4 aut
700	1	a Quirós, J. Ramón4 aut
700	1	a Riitta Jarvelin, Marjo4 aut
700	1	a Rodríguez-Barranco, Miguel4 aut
700	1	a Scott, Robert A.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Slagboom, P. Eline4 aut
700	1	a Spector, Tim D.4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Uitterlinden, André G.4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Weiderpass, Elisabete4 aut
700	1	a Denchi, Eros Lazzerini4 aut
700	1	a Matullo, Giuseppe4 aut
700	1	a Butterworth, Adam S.4 aut
700	1	a Danesh, John4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Nelson, Christopher P.4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Codd, Veryanu University of Leicester,Glenfield Hospital4 aut
710	2	a University of Cambridgeb Glenfield Hospital4 org
773	0	t American Journal of Human Geneticsd : CELL PRESSg 106:3, s. 389-404q 106:3<389-404x 0002-9297x 1537-6605
856	4	u https://doi.org/10.1016/j.ajhg.2020.02.006y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1420894/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.cell.com/article/S0002929720300483/pdf
856	4	u http://dx.doi.org/10.1016/j.ajhg.2020.02.006x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169391
856	4 8	u https://doi.org/10.1016/j.ajhg.2020.02.006
856	4 8	u https://lup.lub.lu.se/record/11710ffd-da84-4326-be0b-382b4af208ad
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143190360

Hitta via bibliotek

American Journal of Human Genetics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Li, Chen; Stoma, Svetlana; Lotta, Luca A.; Warner, Sophie; Albrecht, Eva; Allione, Alessan ...; visa fler...; Arp, Pascal P.; Broer, Linda; Buxton, Jessica ...; Da Silva Couto A ...; Deelen, Joris; Fedko, Iryna O.; Gordon, Scott D.; Jiang, Tao; Karlsson, Robert; Kerrison, Nicola; Loe, Taylor K.; Mangino, Massimo; Milaneschi, Yuri; Miraglio, Benjam ...; Pervjakova, Nata ...; Russo, Alessia; Surakka, Ida; van der Spek, As ...; Verhoeven, Josin ...; Amin, Najaf; Beekman, Marian; Blakemore, Alexa ...; Canzian, Federic ...; Hamby, Stephen E ...; Hottenga, Jouke- ...; Jones, Peter D.; Jousilahti, Pekk ...; Mägi, Reedik; Medland, Sarah E ...; Montgomery, Gran ...; Nyholt, Dale R.; Perola, Markus; Pietiläinen, Kir ...; Salomaa, Veikko; Sillanpää, Elina; Suchiman, H. Eka; van Heemst, Dian ...; Willemsen, Gonne ...; Agudo, Antonio; Boeing, Heiner; Boomsma, Dorret ...; Chirlaque, Maria ...; Fagherazzi, Guy; Ferrari, Pietro; Franks, Paul W.; Gieger, Christia ...; Eriksson, Johan ...; Gunter, Marc; Hagg, Sara; Hovatta, Iiris; Imaz, Liher; Kaprio, Jaakko; Kaaks, Rudolf; Key, Timothy; Krogh, Vittorio; Martin, Nicholas ...; Melander, Olle; Metspalu, Andres; Moreno, Concha; Onland-Moret, N. ...; Nilsson, Peter; Ong, Ken K.; Overvad, Kim; Palli, Domenico; Panico, Salvator ...; Pedersen, Nancy ...; Penninx, Brenda ...; Quirós, J. Ramón; Riitta Jarvelin, ...; Rodríguez-Barran ...; Scott, Robert A.; Severi, Gianluca; Slagboom, P. Eli ...; Spector, Tim D.; Tjonneland, Anne; Trichopoulou, An ...; Tumino, Rosario; Uitterlinden, An ...; van der Schouw, ...; van Duijn, Corne ...; Weiderpass, Elis ...; Denchi, Eros Laz ...; Matullo, Giusepp ...; Butterworth, Ada ...; Danesh, John; Samani, Nilesh J ...; Wareham, Nichola ...; Nelson, Christop ...; Langenberg, Clau ...; Codd, Veryan; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

Artiklar i publikationen: American Journal ...

Av lärosätet: Umeå universitet; Lunds universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se