Sökning: WFRF:(Merrill Joan T.) > Anti-KIF20B autoant...
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000 | 06270naa a2200733 4500 | |
001 | oai:lup.lub.lu.se:4d25c7fb-faef-473c-8988-ed09368aeeef | |
003 | SwePub | |
008 | 240423s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/4d25c7fb-faef-473c-8988-ed09368aeeef2 URI |
024 | 7 | a https://doi.org/10.1136/lupus-2023-0011392 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Krustev, Eugeneu Cumming School of Medicine4 aut |
245 | 1 0 | a Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus |
264 | 1 | c 2024 |
520 | a Background Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort. Methods Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. Anti-KIF20B testing was performed on baseline (within 15 months of diagnosis or first annual visit) samples using an addressable laser bead immunoassay. Logistic regression (penalised maximum likelihood and adjusting for confounding variables) examined the association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN, occurring over the first 5 years of follow-up. Results Of the 1827 enrolled cohort members, baseline serum and 5 years of follow-up data were available on 795 patients who were included in this study: 29.8% were anti-KIF20B-positive, 88.7% female, and 52.1% White. The frequency of anti-KIF20B positivity differed only for those with CN (n=10) versus without CN (n=785) (70.0% vs 29.3%; OR 5.2, 95% CI 1.4, 18.5). Compared with patients without CN, patients with CN were more likely to fulfil the ACR haematological (90.0% vs 66.1%; difference 23.9%, 95% CI 5.0%, 42.8%) and ANA (100% vs 95.7%; difference 4.3%, 95% CI 2.9%, 5.8%) criteria. In the multivariate analysis adjusting for age at baseline, female, White race and ethnicity, and ACR haematological and ANA criteria, anti-KIF20B positivity remained associated with CN (OR 5.2, 95% CI 1.4, 19.1). Conclusion Anti-KIF20B is a potential biomarker for SLE-related CN. Further studies are needed to examine how autoantibodies against KIF20B, which is variably expressed in a variety of neurological cells, contribute to disease pathogenesis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
700 | 1 | a Hanly, John G.u Dalhousie University4 aut |
700 | 1 | a Chin, Rickyu Cumming School of Medicine4 aut |
700 | 1 | a Buhler, Katherine A.u Cumming School of Medicine4 aut |
700 | 1 | a Urowitz, Murray B.4 aut |
700 | 1 | a Gordon, Carolineu University of Birmingham4 aut |
700 | 1 | a Bae, Sang Cheolu Hanyang University Hospital for Rheumatic Disease4 aut |
700 | 1 | a Romero-Diaz, Juanitau Salvador Zubirán National Institute of Health Sciences and Nutrition4 aut |
700 | 1 | a Sánchez-Guerrero, Jorgeu Mount Sinai Hospital of University of Toronto4 aut |
700 | 1 | a Bernatsky, Sashau McGill University Health Center4 aut |
700 | 1 | a Wallace, Daniel J.u Cedars-Sinai Medical Center,University of California, Los Angeles4 aut |
700 | 1 | a Isenberg, Davidu University College London4 aut |
700 | 1 | a Rahman, Anisuru University College London4 aut |
700 | 1 | a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut |
700 | 1 | a Fortin, Paul R.u Laval University4 aut |
700 | 1 | a Gladman, Dafna D.4 aut |
700 | 1 | a Bruce, Ian N.u University of Manchester4 aut |
700 | 1 | a Petri, Michelle A.u Johns Hopkins University School of Medicine4 aut |
700 | 1 | a Ginzler, Ellen M.u SUNY Downstate Health Sciences University4 aut |
700 | 1 | a Dooley, Mary Anneu University of North Carolina4 aut |
700 | 1 | a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine4 aut |
700 | 1 | a Manzi, Susanu Allegheny Health Network4 aut |
700 | 1 | a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)reum-ajo |
700 | 1 | a Alarcón, Graciela S.u University of Alabama at Birmingham School of Medicine4 aut |
700 | 1 | a van Vollenhoven, Ronald F.u University of Amsterdam4 aut |
700 | 1 | a Aranow, Cynthia4 aut |
700 | 1 | a Mackay, Meggan4 aut |
700 | 1 | a Ruiz-Irastorza, Guillermou Biocruces Bizkaia Health Research Institute4 aut |
700 | 1 | a Lim, Samu Emory University4 aut |
700 | 1 | a Inanc, Murat4 aut |
700 | 1 | a Kalunian, Kenneth C.u University of California, San Diego4 aut |
700 | 1 | a Jacobsen, Sørenu Copenhagen University Hospital4 aut |
700 | 1 | a Peschken, Christine A.u University of Manitoba4 aut |
700 | 1 | a Kamen, Diane L.u Medical University of South Carolina4 aut |
700 | 1 | a Askenase, Ancau Columbia University4 aut |
700 | 1 | a Buyon, Jillu NYU Langone4 aut |
700 | 1 | a Fritzler, Marvin J.u Cumming School of Medicine4 aut |
700 | 1 | a Clarke, Ann E.u Cumming School of Medicine4 aut |
700 | 1 | a Choi, May Y.u Cumming School of Medicine4 aut |
710 | 2 | a Cumming School of Medicineb Dalhousie University4 org |
773 | 0 | t Lupus Science and Medicineg 11:1q 11:1x 2053-8790 |
856 | 4 | u http://dx.doi.org/10.1136/lupus-2023-001139x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/4d25c7fb-faef-473c-8988-ed09368aeeef |
856 | 4 8 | u https://doi.org/10.1136/lupus-2023-001139 |
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