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Sökning: WFRF:(Merrill Joan T.) > Anti-KIF20B autoant...

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FältnamnIndikatorerMetadata
00006270naa a2200733 4500
001oai:lup.lub.lu.se:4d25c7fb-faef-473c-8988-ed09368aeeef
003SwePub
008240423s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/4d25c7fb-faef-473c-8988-ed09368aeeef2 URI
0247 a https://doi.org/10.1136/lupus-2023-0011392 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Krustev, Eugeneu Cumming School of Medicine4 aut
2451 0a Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus
264 1c 2024
520 a Background Cranial neuropathies (CN) are a rare neuropsychiatric SLE (NPSLE) manifestation. Previous studies reported that antibodies to the kinesin family member 20B (KIF20B) (anti-KIF20B) protein were associated with idiopathic ataxia and CN. We assessed anti-KIF20B as a potential biomarker for NPSLE in an international SLE inception cohort. Methods Individuals fulfilling the revised 1997 American College of Rheumatology (ACR) SLE classification criteria were enrolled from 31 centres from 1999 to 2011 and followed annually in the Systemic Lupus Erythematosus International Collaborating Clinics inception cohort. Anti-KIF20B testing was performed on baseline (within 15 months of diagnosis or first annual visit) samples using an addressable laser bead immunoassay. Logistic regression (penalised maximum likelihood and adjusting for confounding variables) examined the association between anti-KIF20B and NPSLE manifestations (1999 ACR case definitions), including CN, occurring over the first 5 years of follow-up. Results Of the 1827 enrolled cohort members, baseline serum and 5 years of follow-up data were available on 795 patients who were included in this study: 29.8% were anti-KIF20B-positive, 88.7% female, and 52.1% White. The frequency of anti-KIF20B positivity differed only for those with CN (n=10) versus without CN (n=785) (70.0% vs 29.3%; OR 5.2, 95% CI 1.4, 18.5). Compared with patients without CN, patients with CN were more likely to fulfil the ACR haematological (90.0% vs 66.1%; difference 23.9%, 95% CI 5.0%, 42.8%) and ANA (100% vs 95.7%; difference 4.3%, 95% CI 2.9%, 5.8%) criteria. In the multivariate analysis adjusting for age at baseline, female, White race and ethnicity, and ACR haematological and ANA criteria, anti-KIF20B positivity remained associated with CN (OR 5.2, 95% CI 1.4, 19.1). Conclusion Anti-KIF20B is a potential biomarker for SLE-related CN. Further studies are needed to examine how autoantibodies against KIF20B, which is variably expressed in a variety of neurological cells, contribute to disease pathogenesis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Hanly, John G.u Dalhousie University4 aut
7001 a Chin, Rickyu Cumming School of Medicine4 aut
7001 a Buhler, Katherine A.u Cumming School of Medicine4 aut
7001 a Urowitz, Murray B.4 aut
7001 a Gordon, Carolineu University of Birmingham4 aut
7001 a Bae, Sang Cheolu Hanyang University Hospital for Rheumatic Disease4 aut
7001 a Romero-Diaz, Juanitau Salvador Zubirán National Institute of Health Sciences and Nutrition4 aut
7001 a Sánchez-Guerrero, Jorgeu Mount Sinai Hospital of University of Toronto4 aut
7001 a Bernatsky, Sashau McGill University Health Center4 aut
7001 a Wallace, Daniel J.u Cedars-Sinai Medical Center,University of California, Los Angeles4 aut
7001 a Isenberg, Davidu University College London4 aut
7001 a Rahman, Anisuru University College London4 aut
7001 a Merrill, Joan T.u Oklahoma Medical Research Foundation4 aut
7001 a Fortin, Paul R.u Laval University4 aut
7001 a Gladman, Dafna D.4 aut
7001 a Bruce, Ian N.u University of Manchester4 aut
7001 a Petri, Michelle A.u Johns Hopkins University School of Medicine4 aut
7001 a Ginzler, Ellen M.u SUNY Downstate Health Sciences University4 aut
7001 a Dooley, Mary Anneu University of North Carolina4 aut
7001 a Ramsey-Goldman, Rosalindu Northwestern University Feinberg School of Medicine4 aut
7001 a Manzi, Susanu Allegheny Health Network4 aut
7001 a Jönsen, Andreasu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)reum-ajo
7001 a Alarcón, Graciela S.u University of Alabama at Birmingham School of Medicine4 aut
7001 a van Vollenhoven, Ronald F.u University of Amsterdam4 aut
7001 a Aranow, Cynthia4 aut
7001 a Mackay, Meggan4 aut
7001 a Ruiz-Irastorza, Guillermou Biocruces Bizkaia Health Research Institute4 aut
7001 a Lim, Samu Emory University4 aut
7001 a Inanc, Murat4 aut
7001 a Kalunian, Kenneth C.u University of California, San Diego4 aut
7001 a Jacobsen, Sørenu Copenhagen University Hospital4 aut
7001 a Peschken, Christine A.u University of Manitoba4 aut
7001 a Kamen, Diane L.u Medical University of South Carolina4 aut
7001 a Askenase, Ancau Columbia University4 aut
7001 a Buyon, Jillu NYU Langone4 aut
7001 a Fritzler, Marvin J.u Cumming School of Medicine4 aut
7001 a Clarke, Ann E.u Cumming School of Medicine4 aut
7001 a Choi, May Y.u Cumming School of Medicine4 aut
7102 a Cumming School of Medicineb Dalhousie University4 org
7730 t Lupus Science and Medicineg 11:1q 11:1x 2053-8790
8564 u http://dx.doi.org/10.1136/lupus-2023-001139x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/4d25c7fb-faef-473c-8988-ed09368aeeef
8564 8u https://doi.org/10.1136/lupus-2023-001139

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