SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Moen I.)
 

Sökning: WFRF:(Moen I.) > Epigenome-wide asso...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004310naa a2200409 4500
001oai:lup.lub.lu.se:ffb3ab34-fd69-4888-ab10-296a63c323dd
003SwePub
008240219| | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/ffb3ab34-fd69-4888-ab10-296a63c323dd2 URI
0247 a https://doi.org/10.1038/s41366-024-01458-x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Opsahl, J. O.u University of Oslo4 aut
2451 0a Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain
520 a Objectives: We aimed to discover CpG sites with differential DNA methylation in peripheral blood leukocytes associated with body mass index (BMI) in pregnancy and gestational weight gain (GWG) in women of European and South Asian ancestry. Furthermore, we aimed to investigate how the identified sites were associated with methylation quantitative trait loci, gene ontology, and cardiometabolic parameters. Methods: In the Epigenetics in pregnancy (EPIPREG) sample we quantified maternal DNA methylation in peripheral blood leukocytes in gestational week 28 with Illumina’s MethylationEPIC BeadChip. In women with European (n = 303) and South Asian (n = 164) ancestry, we performed an epigenome-wide association study of BMI in gestational week 28 and GWG between gestational weeks 15 and 28 using a meta-analysis approach. Replication was performed in the Norwegian Mother, Father, and Child Cohort Study, the Study of Assisted Reproductive Technologies (MoBa-START) (n = 877, mainly European/Norwegian). Results: We identified one CpG site significantly associated with GWG (p 5.8 × 10−8) and five CpG sites associated with BMI at gestational week 28 (p from 4.0 × 10–8 to 2.1 × 10–10). Of these, we were able to replicate three in MoBa-START; cg02786370, cg19758958 and cg10472537. Two sites are located in genes previously associated with blood pressure and BMI. DNA methylation at the three replicated CpG sites were associated with levels of blood pressure, lipids and glucose in EPIPREG (p from 1.2 × 10−8 to 0.04). Conclusions: We identified five CpG sites associated with BMI at gestational week 28, and one with GWG. Three of the sites were replicated in an independent cohort. Several genetic variants were associated with DNA methylation at cg02786379 and cg16733643 suggesting a genetic component influencing differential methylation. The identified CpG sites were associated with cardiometabolic traits. ClinicalTrials.gov
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Fragoso-Bargas, N.u University of Oslo,Oslo university hospital4 aut0 (Swepub:lu)ni2035fr
7001 a Lee, Y.u Norwegian Institute of Public Health4 aut
7001 a Carlsen, E.u Norwegian Institute of Public Health4 aut
7001 a Lekanova, N.u University of Oslo4 aut
7001 a Qvigstad, E.u University of Oslo,Oslo university hospital4 aut
7001 a Sletner, L.u Akershus University Hospital4 aut
7001 a Jenum, A. K.u University of Oslo4 aut
7001 a Lee-Ødegård, S.u University of Oslo4 aut
7001 a Prasad, R. B.u Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)med-rpa
7001 a Birkeland, K. I.u Oslo university hospital,University of Oslo4 aut
7001 a Moen, G. H.u University of Bristol,University of Oslo,Norwegian University of Science and Technology,University of Queensland4 aut
7001 a Sommer, C.u Oslo university hospital4 aut
7102 a University of Oslob Oslo university hospital4 org
7730 t International Journal of Obesityx 0307-0565
8564 u http://dx.doi.org/10.1038/s41366-024-01458-xx freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/ffb3ab34-fd69-4888-ab10-296a63c323dd
8564 8u https://doi.org/10.1038/s41366-024-01458-x

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy