Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men

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Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men

Marsell, Richard (author): Uppsala universitet,Ortopedi

Mirza, M. A. (author): Uppsala universitet,Institutionen för medicinska vetenskaper

Mallmin, Hans (author): Uppsala universitet,Ortopedi

Karlsson, Magnus (author): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups

Mellström, Dan, 1945 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine

Orwoll, E. (author)

Ohlsson, Claes, 1965 (author): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine

Jonsson, Kenneth B (author): Uppsala universitet,Ortopedi

Ljunggren, Östen (author): Uppsala universitet,Institutionen för medicinska vetenskaper

Larsson, T. E. (author): Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper

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(creator_code:org_t)

2008-10-31
2009
English.
In: Osteoporosis International. - : Springer Science and Business Media LLC. - 0937-941X .- 1433-2965. ; 20:7, s. 1167-1173

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Journal article (peer-reviewed)

Abstract Subject headings

We evaluated the relation between serum FGF23 and bone mineral density (BMD) in a community-based cohort of elderly men. There was a weak correlation between FGF23 and BMD, which was primarily dependent on body weight.INTRODUCTION: FGF23 is a hormonal factor produced in bone and regulates serum levels of phosphate (Pi) and vitamin D. FGF23 over-expression is associated with skeletal abnormalities, including rickets/osteomalacia. The relation between FGF23 and Bone Mineral Density (BMD) in the community remains unexplored.METHODS: We employed a large, population-based cohort of 3014 Swedish men aged 69-80 years, without known renal disease. BMD was measured with dual X-ray absorptiometry (DXA) in the hip and lumbar spine. Serum intact FGF23 was analyzed with a two-site monoclonal ELISA.RESULTS: There was a weak but significant correlation between FGF23 and BMD in femoral neck (r = 0.04, p < 0.05), femoral trochanter (r = 0.05, p = 0.004), total hip (r = 0.06, p = 0.0015) and lumbar spine (r = 0.07, p = 0.0004). The correlations remained significant when adjusting for biochemical covariates (Pi, calcium, PTH, 25(OH)D and renal function). However, the association became insignificant in all regions when adjusting for established confounding variables including age, height, weight and smoking. Further analysis confirmed a significant correlation between FGF23 and body weight (r = 0.13, p < 0.0001).CONCLUSIONS: The weak correlation between FGF23 and BMD in elderly male subjects is mainly due to an association between FGF23 and body weight. Therefore, FGF23 may not play a significant role in the hormonal regulation of BMD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

BMD
Bone densitometry
Bone mineralization
FGF-23
Fibroblast growth factor 23
Growth factors
Orthopaedics
Ortopedi
Bone mineralization
FGF-23
Fibroblast growth
Growth factors
factor 23
Bone densitometry
BMD

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Marsell, Richard; Mirza, M. A.; Mallmin, Hans; Karlsson, Magnus; Mellström, Dan, ...; Orwoll, E.; show more...; Ohlsson, Claes, ...; Jonsson, Kenneth ...; Ljunggren, Östen; Larsson, T. E.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: Osteoporosis Int ...

By the university: Uppsala University; Lund University; University of Gothenburg; Karolinska Institutet

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