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WFRF:(Pauksen Karlis)
 

Sökning: WFRF:(Pauksen Karlis) > Subsets of T-cells ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003426naa a2200385 4500
001oai:DiVA.org:uu-54535
003SwePub
008081017s1999 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1943449
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-545352 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19434492 URI
0247 a https://doi.org/10.1080/003655499501618712 DOI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Pauksen, Karlisu Uppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion4 aut0 (Swepub:uu)karlpauk
2451 0a Subsets of T-cells and in vitro cytokine production after measles and varicellae-zoster virus antigen stimulation in allogeneic BMT patients
264 1b Informa UK Limited,c 1999
338 a print2 rdacarrier
520 a This study was performed to analyse differences in T-cell proliferation induced by a latent virus, varicellae-zoster virus (VZV) and a non-latent virus, measles virus, in patients after allogeneic bone marrow transplantation (BMT). The lymphoproliferative response to measles antigen, VZV-antigen (VZV-ag), and phytohemagglutinin (PHA) was measured by 3H-thymidine incorporation, and interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) analyses in supernatants after in vitro stimulation of peripheral blood mononuclear cells (PBMC) from 22 patients and 18 healthy controls. The cytokine levels were correlated with T-cell subsets by FACS analyses. At the antigen concentrations used, VZV-ag induced higher levels of IFN-gamma (p < 0.05) than did the measles antigen, whereas the levels of IL-10 were similar. Patients without a cell mediated immune (CMI) response to VZV-ag or measles antigen had lower CD4+ T-cell counts than did controls (p < 0.01 in both cases) and lower IFN-gamma production after non-specific PHA stimulation (p <0.01). The IFN-gamma and IL-10 levels after measles antigen stimulation correlated with the number of CD4+ T-cells (p < 0.01 and p < 0.05, respectively), and after VZV-ag mainly to the number of CD8+ T-cells (p < 0.01 and p < 0.05, respectively). These results suggest that there is a difference in the types of T-cells that respond to VZV-ag and measles antigen stimulation, respectively. The impaired CMI response to viral antigens seen in many patients may be explained both by a low number of CD4+ T-cells and by a cell dysfunction.
653 a MEDICINE
653 a MEDICIN
7001 a Sjölin, Janu Uppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion4 aut
7001 a Linde, Annika4 aut
7001 a Andersson, Birger4 aut
7001 a Lenkei, Rodica4 aut
7001 a Öberg, Gunnaru Uppsala universitet,Institutionen för medicinska vetenskaper,Hematologigruppen, B Simonsson4 aut
7001 a Ljungman, Peru Karolinska Institutet4 aut
7102 a Uppsala universitetb Institutionen för medicinska vetenskaper4 org
7730 t Scandinavian Journal of Infectious Diseasesd : Informa UK Limitedg 31:1, s. 43-49q 31:1<43-49x 0036-5548x 1651-1980
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-54535
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1943449
8564 8u https://doi.org/10.1080/00365549950161871

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