Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry

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Fältnamn	Indikatorer	Metadata
000		04514naa a2200445 4500
001		oai:DiVA.org:oru-95785
003		SwePub
008		211208s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-957852 URI
024	7	a https://doi.org/10.1080/1354750X.2021.20135382 DOI
040		a (SwePub)oru
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hedbrant, Alexander,d 1987-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)arht
245	1 0	a Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry
264	1	b Taylor & Francis,c 2022
338		a print2 rdacarrier
500		a Funding agency:ORU 2.2.1-4060/2013
520		a INTRODUCTION: In light of potential negative health effects of cobalt exposure, a characterization of inflammatory mechanisms in exposed individuals is warranted. The current study investigated cobalt exposure in the Swedish hard metal industry and its relationship to inflammatory markers, including NLRP3 inflammasome activation and white blood cell (WBC) counts.MATERIAL AND METHODS: Inhalable cobalt and dust exposures, and systemic cobalt levels, were determined for 72 workers in the hard metal industry and linear regression models were applied to correlate exposure to markers of inflammasome activation and WBC counts.RESULTS: Mean exposures to inhalable dust (0.11 mg/m3) and cobalt (0.0034 mg/m3) were below the Swedish occupational exposure limits, and these low exposures did not correlate with any investigated outcomes. Instead, cobalt blood levels significantly correlated with a ca 10% decrease in IL-18 plasma levels per 10 nM cobalt increase. Furthermore, pre-shift cobalt blood and/or urine levels significantly correlated with some WBC measures, including decreased neutrophil-to-lymphocyte ratio, increased lymphocyte-to-monocyte ratio, and lymphocyte counts.CONCLUSION: The low inhalable particle exposures had no impact on WBC counts and inflammasome activation. Instead, systemic cobalt levels, which also include skin exposure, demonstrated possible suppressive effects on inflammatory responses in cobalt-exposed individuals in the hard metal industry.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653		a IL-18
653		a Inflammatory markers
653		a LMR
653		a NLR
653		a caspase-1
653		a particle exposure
700	1	a Eklund, Daniel,d 1984-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)ded
700	1	a Andersson, Lena,d 1965-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)laas
700	1	a Bryngelsson, Ing-Lissu Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden4 aut
700	1	a Persson, Alexander,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)axpn
700	1	a Westberg, Håkan,d 1949-u Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)hwg
700	1	a Särndahl, Eva,d 1963-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC)4 aut0 (Swepub:oru)easl
710	2	a Örebro universitetb Institutionen för medicinska vetenskaper4 org
773	0	t Biomarkersd : Taylor & Francisg , s. 60-70q <60-70x 1354-750Xx 1366-5804
856	4	u https://doi.org/10.1080/1354750X.2021.2013538y Fulltext
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-95785
856	4 8	u https://doi.org/10.1080/1354750X.2021.2013538

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