Sökning: WFRF:(Samuelsson Martin) > (2010-2014) > Imbalanced Kynureni...
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000 | 04191naa a2200445 4500 | |
001 | oai:DiVA.org:liu-110785 | |
003 | SwePub | |
008 | 140922s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:225288889 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1107852 URI |
024 | 7 | a https://doi.org/10.4137/IJTR.S168002 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2252888892 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kegel, Magdalena E.u Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden4 aut |
245 | 1 0 | a Imbalanced Kynurenine Pathway in Schizophrenia |
264 | 1 | b Libertas Academica,c 2014 |
338 | a electronic2 rdacarrier | |
520 | a Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhanced KYNA formation, away from the other branch of the pathway leading to quinolinic acid (QUIN). Here we investigate the levels of QUIN in cerebrospinal fluid (CSF) of patients with schizophrenia and healthy controls, and relate those to CSF levels of KYNA and other kynurenine metabolites from the same individuals. CSF QUIN levels from stable outpatients treated with olanzapine (n = 22) and those of controls (n = 26) were analyzed using liquid chromatography-mass spectrometry. No difference in CSF QUIN levels between patients and controls was observed (20.6 ± 1.5 nM vs. 18.2 ± 1.1 nM, P = 0.36). CSF QUIN was positively correlated to CSF kynurenine and CSF KYNA in patients but not in controls. The CSF QUIN/KYNA ratio was lower in patients than in controls (P = 0.027). In summary, the present study offers support for an over-activated and imbalanced kynurenine pathway, favoring the production of KYNA over QUIN in patients with schizophrenia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
700 | 1 | a Bhat, Mariau AstraZeneca, Research and Development, Innovative Medicines, Personalised Healthcare and Biomarkers, Translational Science Centre, Science for Life Laboratory, Solna, Sweden / Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden4 aut |
700 | 1 | a Skogh, Elisabethu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Psykiatriska kliniken4 aut0 (Swepub:liu)elisk66 |
700 | 1 | a Samuelsson, Martinu Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet,Psykiatriska kliniken4 aut0 (Swepub:liu)marsa78 |
700 | 1 | a Lundberg, Kristinau Linköpings universitet,Avdelningen för neurovetenskap,Hälsouniversitetet4 aut |
700 | 1 | a Dahl, Marja-Liisau Karolinska Institutet4 aut |
700 | 1 | a Sellgren, Carlu Karolinska Institutet4 aut |
700 | 1 | a Schwieler, Lillyu Karolinska Institutet4 aut |
700 | 1 | a Engberg, Göranu Karolinska Institutet4 aut |
700 | 1 | a Schuppe-Koistinen, Inau Karolinska Institutet4 aut |
700 | 1 | a Erhardt, Sophieu Karolinska Institutet4 aut |
710 | 2 | a Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Swedenb AstraZeneca, Research and Development, Innovative Medicines, Personalised Healthcare and Biomarkers, Translational Science Centre, Science for Life Laboratory, Solna, Sweden / Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden4 org |
773 | 0 | t International Journal of Tryptophan Researchd : Libertas Academicag 7, s. 15-22q 7<15-22x 1178-6469 |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:748978/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110785 |
856 | 4 8 | u https://doi.org/10.4137/IJTR.S16800 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:225288889 |
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