WFRF:(Sharp David J.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03968naa a2200481 4500 | |
| 001 | oai:gup.ub.gu.se/340859 | |
| 003 | SwePub | |
| 008 | 240911s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3408592 URI |
| 024 | 7 | a https://doi.org/10.1002/adhm.2024019662 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Li, Yixuan4 aut |
| 245 | 1 0 | a An Ultrasensitive Molecularly Imprinted Point-Of-Care Electrochemical Sensor for Detection of Glial Fibrillary Acidic Protein |
| 264 | 1 | c 2024 |
| 520 | a Accurate assessment of neurological disease through monitoring of biomarkers has been made possible using the antibody-based assays. But these assays suffer from expensive development of antibody probes, reliance on complicated equipments, and high maintenance costs. Here, using the novel reduced graphene oxide/polydopamine-molecularly imprinted polymer (rGO/PDA-MIP) as the probe layer, a robust electrochemical sensing platform is demonstrated for the ultrasensitive detection of glial fibrillary acidic protein (GFAP), a biomarker for a range of neurological diseases. A miniaturized integrated circuit readout system is developed to interface with the electrochemical sensor, which empowers it with the potential to be used as a point-of-care (POC) diagnostic tool in primary clinical settings. This innovative platform demonstrated good sensitivity, selectivity, and stability, with imprinting factor evaluated as 2.8. A record low limit-of-detection (LoD) is down to 754.5 ag mL-1, with a wide dynamic range from 1 to 106 fg mL-1. The sensing platform is validated through the analysis of GFAP in clinical plasma samples, yielding a recovery rate range of 81.6-108.8% compared to Single Molecule Array (Simoa). This cost-effective and user-friendly sensing platform holds the potential to be deployed in primary and resource-limited clinical settings for the assessment of neurological diseases. A novel reduced graphene oxide/polydopamine-molecularly imprinted polymer (rGO/PDA-MIP) point-pf-care (POC) sensing platform for the detection of glial fibrillary acidic protein (GFAP) is developed, which shows remarkably high sensitivity, selectivity, robustness, and record limit-of-detection (LoD) at attomolar level with expansive detection range, making it a promising approach for screening for neurological diseases and monitoring progression. image | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a glial fibrillary acidic protein | |
| 653 | a molecularly imprinted polymer | |
| 653 | a neurological disease monitoring | |
| 653 | a point-of-care electrochemical sensor | |
| 653 | a reduced graphene oxide | |
| 700 | 1 | a Luo, Liuxiong4 aut |
| 700 | 1 | a Senicar, Lenart4 aut |
| 700 | 1 | a Asrosa, Rica4 aut |
| 700 | 1 | a Kizilates, Burcu4 aut |
| 700 | 1 | a Xing, Kaizhong4 aut |
| 700 | 1 | a Torres, Elias4 aut |
| 700 | 1 | a Xu, Lizhou4 aut |
| 700 | 1 | a Li, Danyang4 aut |
| 700 | 1 | a Graham, Neil4 aut |
| 700 | 1 | a Heslegrave, Amanda4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Sharp, David J.4 aut |
| 700 | 1 | a Li, Bing4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t ADVANCED HEALTHCARE MATERIALSx 2192-2640x 2192-2659 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/340859 |
| 856 | 4 8 | u https://doi.org/10.1002/adhm.202401966 |
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