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|---|---|---|
| 000 | 12855naa a2203037 4500 | |
| 001 | oai:DiVA.org:uu-182772 | |
| 003 | SwePub | |
| 008 | 121015s2012 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:0ef9bf29-b272-4fdd-9203-e7a36d754113 | |
| 009 | oai:prod.swepub.kib.ki.se:125253560 | |
| 009 | oai:DiVA.org:umu-60519 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1827722 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.23852 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/31395062 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1252535602 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-605192 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Scott, Robert A.4 aut |
| 245 | 1 0 | a Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways |
| 264 | c 2012-08-12 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2012 |
| 338 | a print2 rdacarrier | |
| 500 | a De fem sista författarna delar sistaförfattarskapet. | |
| 520 | a Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 700 | 1 | a Lagou, Vasiliki4 aut |
| 700 | 1 | a Welch, Ryan P.4 aut |
| 700 | 1 | a Wheeler, Eleanor4 aut |
| 700 | 1 | a Montasser, May E.4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Maegi, Reedik4 aut |
| 700 | 1 | a Strawbridge, Rona J.u Karolinska Institutet4 aut |
| 700 | 1 | a Rehnberg, Emil4 aut |
| 700 | 1 | a Gustafsson, Stefan4 aut |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Rasmussen-Torvik, Laura J.4 aut |
| 700 | 1 | a Yengo, Loic4 aut |
| 700 | 1 | a Lecoeur, Cecile4 aut |
| 700 | 1 | a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Institutionen för odontologi,Medicin4 aut0 (Swepub:umu)dmsh0003 |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Sidore, Carlo4 aut |
| 700 | 1 | a Johnson, Paul C. D.4 aut |
| 700 | 1 | a Jukema, J. Wouter4 aut |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Mahajan, Anubha4 aut |
| 700 | 1 | a Verweij, Niek4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Hottenga, Jouke-Jan4 aut |
| 700 | 1 | a Shah, Sonia4 aut |
| 700 | 1 | a Smith, Albert V.4 aut |
| 700 | 1 | a Sennblad, Bengtu Karolinska Institutet4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Salo, Perttu4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Timpson, Nicholas J.4 aut |
| 700 | 1 | a Evans, David M.4 aut |
| 700 | 1 | a St Pourcain, Beate4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Andrews, Jeanette S.4 aut |
| 700 | 1 | a Hui, Jennie4 aut |
| 700 | 1 | a Bielak, Lawrence F.4 aut |
| 700 | 1 | a Zhao, Wei4 aut |
| 700 | 1 | a Horikoshi, Momoko4 aut |
| 700 | 1 | a Navarro, Pau4 aut |
| 700 | 1 | a Isaacs, Aaron4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a V Varga, Tiboru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)med-tv_ |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Fraser, Ross M.4 aut |
| 700 | 1 | a Fall, Tove,d 1979-u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:uu)tovfa878 |
| 700 | 1 | a Voight, Benjamin F.4 aut |
| 700 | 1 | a Raychaudhuri, Soumya4 aut |
| 700 | 1 | a Chen, Han4 aut |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a Morris, Andrew P.4 aut |
| 700 | 1 | a Rayner, Nigel W.4 aut |
| 700 | 1 | a Robertson, Neil4 aut |
| 700 | 1 | a Rybin, Denis4 aut |
| 700 | 1 | a Liu, Ching-Ti4 aut |
| 700 | 1 | a Beckmann, Jacques S.4 aut |
| 700 | 1 | a Willems, Sara M.4 aut |
| 700 | 1 | a Chines, Peter S.4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Kang, Hyun Min4 aut |
| 700 | 1 | a Stringham, Heather M.4 aut |
| 700 | 1 | a Song, Kijoung4 aut |
| 700 | 1 | a Tanaka, Toshiko4 aut |
| 700 | 1 | a Peden, John F.4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a An, Ping4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Franco-Cereceda, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Folkersen, Lasse4 aut |
| 700 | 1 | a Marullo, Letizia4 aut |
| 700 | 1 | a Jansen, Hanneke4 aut |
| 700 | 1 | a Oldehinkel, Albertine J.4 aut |
| 700 | 1 | a Bruinenberg, Marcel4 aut |
| 700 | 1 | a Pankow, James S.4 aut |
| 700 | 1 | a North, Kari E.4 aut |
| 700 | 1 | a Forouhi, Nita G.4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Edkins, Sarah4 aut |
| 700 | 1 | a Varga, Tibor V.4 aut |
| 700 | 1 | a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
| 700 | 1 | a Oksa, Heikki4 aut |
| 700 | 1 | a Antonella, Mulas4 aut |
| 700 | 1 | a Nagaraja, Ramaiah4 aut |
| 700 | 1 | a Trompet, Stella4 aut |
| 700 | 1 | a Ford, Ian4 aut |
| 700 | 1 | a Lind, Larsu Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Kong, Augustine4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
| 700 | 1 | a Herder, Christian4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Caulfield, Mark4 aut |
| 700 | 1 | a Antti, Jula4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Small, Kerrin4 aut |
| 700 | 1 | a Miljkovic, Iva4 aut |
| 700 | 1 | a Liu, Yongmei4 aut |
| 700 | 1 | a Atalay, Mustafa4 aut |
| 700 | 1 | a Kiess, Wieland4 aut |
| 700 | 1 | a James, Alan L.4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Palmer, Colin N. A.4 aut |
| 700 | 1 | a Doney, Alex S. F.4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Smit, Johannes H.4 aut |
| 700 | 1 | a Campbell, Susan4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Bonnycastle, Lori L.4 aut |
| 700 | 1 | a Hercberg, Serge4 aut |
| 700 | 1 | a Dimitriou, Maria4 aut |
| 700 | 1 | a Bolton, Jennifer L.4 aut |
| 700 | 1 | a Fowkes, Gerard R.4 aut |
| 700 | 1 | a Kovacs, Peteru Karolinska Institutet4 aut |
| 700 | 1 | a Lindstrom, Jaana4 aut |
| 700 | 1 | a Zemunik, Tatijana4 aut |
| 700 | 1 | a Bandinelli, Stefania4 aut |
| 700 | 1 | a Wild, Sarah H.4 aut |
| 700 | 1 | a Basart, Hanneke V.4 aut |
| 700 | 1 | a Rathmann, Wolfgang4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Maerz, Winfried4 aut |
| 700 | 1 | a Kleber, Marcus E.4 aut |
| 700 | 1 | a Boehm, Bernhard O.4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Province, Michael A.4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Hastie, Nicholas D.4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Farrall, Martin4 aut |
| 700 | 1 | a Stumvoll, Michael4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Waterworth, Dawn M.4 aut |
| 700 | 1 | a Bergman, Richard N.4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Watanabe, Richard M.4 aut |
| 700 | 1 | a de Geus, Eco J. C.4 aut |
| 700 | 1 | a Penninx, Brenda W.4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Oostra, Ben A.4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Wright, Alan F.4 aut |
| 700 | 1 | a Hovingh, G. Kees4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.4 aut |
| 700 | 1 | a Kyvik, Kirsten O.4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Price, Jackie F.4 aut |
| 700 | 1 | a Dedoussis, George V.4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Meneton, Pierre4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Shuldiner, Alan R.4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Morris, Andrew D.4 aut |
| 700 | 1 | a Toenjes, Anke4 aut |
| 700 | 1 | a Peyser, Patricia A.4 aut |
| 700 | 1 | a Beilby, John P.4 aut |
| 700 | 1 | a Koerner, Antje4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Bornstein, Stefan R.4 aut |
| 700 | 1 | a Schwarz, Peter E. H.4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Adair, Linda S.4 aut |
| 700 | 1 | a Smith, George Davey4 aut |
| 700 | 1 | a Spector, Tim D.4 aut |
| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a Hamsten, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Hingorani, Aroon4 aut |
| 700 | 1 | a Keinanen-Kiukaanniemi, Sirkka M.4 aut |
| 700 | 1 | a Saaristo, Timo E.4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Dupuis, Josee4 aut |
| 700 | 1 | a Pedersen, Nancy L.4 aut |
| 700 | 1 | a Sattar, Naveed4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Cucca, Francesco4 aut |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Balkau, Beverley4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Pouta, Anneli4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Bouatia-Naji, Nabila4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Medicin4 aut0 (Swepub:umu)pafr0003 |
| 700 | 1 | a Meigs, James B.4 aut |
| 700 | 1 | a Teslovich, Tanya M.4 aut |
| 700 | 1 | a Florez, Jose C.4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Ingelsson, Eriku Karolinska Institutet4 aut |
| 700 | 1 | a Prokopenko, Inga4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för kliniska vetenskaper, Malmö4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 44:9, s. 991-1005q 44:9<991-1005x 1061-4036x 1546-1718 |
| 856 | 4 | u https://pure.mpg.de/pubman/item/item_2196711_4/component/file_2241443/Scott_etal_large-scale_2012.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/ng.2385y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182772 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.2385 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3139506 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125253560 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60519 |
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