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Body mass index inc...
Body mass index increase: a risk factor for forced expiratory volume in 1 s decline for overweight and obese adults with asthma
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- Bermúdez Barón, Nicolás (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Kankaanranta, Hannu, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Dept of Internal Medicine and Clinical Nutrition, Krefting Research Centre, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; Faculty of Medicine and Health Technology, Tampere University, Respiratory Research Group, Tampere University, Tampere, Finland; Dept of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland
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- Hedman, Linnea, 1979- (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Andersson, Martin (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Stridsman, Caroline (författare)
- Umeå universitet,Avdelningen för medicin
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- Lindberg, Anne (författare)
- Umeå universitet,Avdelningen för medicin
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- Rönmark, Eva (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Backman, Helena (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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(creator_code:org_t)
- 2022-08-04
- 2022
- Engelska.
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Ingår i: European Respiratory Journal Open Research (ERJ Open Research). - : European Respiratory Society (ERS). - 2312-0541. ; 8:4
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background With increasing prevalence of overweight and obesity, it is important to study how body mass index (BMI) change may affect lung function among subjects with asthma. There are few prospective studies on this topic, especially with separate analyses of those with normal and high BMI. The aim of the present study was to prospectively study the association between annual BMI change and annual lung function decline, separately among those with normal initial BMI and overweight/obesity, in an adult asthma cohort. Methods A population-based adult asthma cohort was examined at study entry between 1986 and 2001 and at follow-up between 2012 and 2014 (n=945). Annual BMI change was analysed in association with annual decline in forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC separately in those with normal weight (BMI 18.5-24.9) and overweight/obese subjects (BMI >= 25) at study entry. Regression models were used to adjust for sex, age, smoking, inhaled corticosteroids use and occupational exposure to gas, dust or fumes. Results Overweight/obese subjects had lower FEV1 and FVC but slower annual FEV1 and FVC decline compared to those with normal weight. After adjustment through regression modelling, the association between BMI change with FEV1 and FVC decline remained significant for both BMI groups, but with stronger associations among the overweight/obese (FEV1 B-[Overweight/obese]=-25 mL versus B[ normal weight]= -15 mL). However, when including only those with BMI increase during follow-up, the associations remained significant among those with overweight/obesity, but not in the normal-weight group. No associations were seen for FEV1/FVC. Conclusions BMI increase is associated with faster FEV1 and FVC decline among overweight and obese adults with asthma in comparison with their normal-weight counterparts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- pulmonary-function
- cluster-analysis
- lung-function
- weight-loss
- inflammation
- smoking
- people
- Respiratory System
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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