Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

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Fältnamn	Indikatorer	Metadata
000		07772naa a2201645 4500
001		oai:DiVA.org:umu-206299
003		SwePub
008		230404s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:144823895
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2062992 URI
024	7	a https://doi.org/10.1002/hbm.252062 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1448238952 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a de Zwarte, Sonja M. C.4 aut
245	1 0	a Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder
264		c 2020-10-07
264	1	b John Wiley & Sons,c 2022
338		a electronic2 rdacarrier
520		a First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 × 10-5 ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a bipolar disorder
653		a education
653		a intelligence
653		a neuroimaging
653		a relatives
653		a schizophrenia
700	1	a Brouwer, Rachel M.4 aut
700	1	a Agartz, Ingridu Karolinska Institutet4 aut
700	1	a Alda, Martin4 aut
700	1	a Alonso-Lana, Silvia4 aut
700	1	a Bearden, Carrie E.4 aut
700	1	a Bertolino, Alessandro4 aut
700	1	a Bonvino, Aurora4 aut
700	1	a Bramon, Elvira4 aut
700	1	a Buimer, Elizabeth E. L.4 aut
700	1	a Cahn, Wiepke4 aut
700	1	a Canales-Rodríguez, Erick J.4 aut
700	1	a Cannon, Dara M.4 aut
700	1	a Cannon, Tyrone D.4 aut
700	1	a Caseras, Xavier4 aut
700	1	a Castro-Fornieles, Josefina4 aut
700	1	a Chen, Qiang4 aut
700	1	a Chung, Yoonho4 aut
700	1	a De la Serna, Elena4 aut
700	1	a Del Mar Bonnin, Caterina4 aut
700	1	a Demro, Caroline4 aut
700	1	a Di Giorgio, Annabella4 aut
700	1	a Doucet, Gaelle E.4 aut
700	1	a Eker, Mehmet Cagdas4 aut
700	1	a Erk, Susanne4 aut
700	1	a Fatjó-Vilas, Mar4 aut
700	1	a Fears, Scott C.4 aut
700	1	a Foley, Sonya F.4 aut
700	1	a Frangou, Sophia4 aut
700	1	a Fullerton, Janice M.4 aut
700	1	a Glahn, David C.4 aut
700	1	a Goghari, Vina M.4 aut
700	1	a Goikolea, Jose M.4 aut
700	1	a Goldman, Aaron L.4 aut
700	1	a Gonul, Ali Saffet4 aut
700	1	a Gruber, Oliver4 aut
700	1	a Hajek, Tomas4 aut
700	1	a Hawkins, Emma L.4 aut
700	1	a Heinz, Andreas4 aut
700	1	a Hidiroglu Ongun, Ceren4 aut
700	1	a Hillegers, Manon H.J.4 aut
700	1	a Houenou, Josselin4 aut
700	1	a Hulshoff Pol, Hilleke E.4 aut
700	1	a Hultman, Christina M.4 aut
700	1	a Ingvar, Martin4 aut
700	1	a Johansson, Viktoriau Karolinska Institutet4 aut0 (Swepub:umu)vijo2972
700	1	a Jönsson, Erik G.u Karolinska Institutet4 aut
700	1	a Kane, Fergus4 aut
700	1	a Kempton, Matthew J.4 aut
700	1	a Koenis, Marinka M. G.4 aut
700	1	a Kopecek, Miloslav4 aut
700	1	a Krämer, Bernd4 aut
700	1	a Lawrie, Stephen M.4 aut
700	1	a Lenroot, Rhoshel K.4 aut
700	1	a Marcelis, Machteld4 aut
700	1	a Mattay, Venkata S.4 aut
700	1	a McDonald, Colm4 aut
700	1	a Meyer-Lindenberg, Andreas4 aut
700	1	a Michielse, Stijn4 aut
700	1	a Mitchell, Philip B.4 aut
700	1	a Moreno, Dolores4 aut
700	1	a Murray, Robin M.4 aut
700	1	a Mwangi, Benson4 aut
700	1	a Nabulsi, Leila4 aut
700	1	a Newport, Jason4 aut
700	1	a Olman, Cheryl A.4 aut
700	1	a van Os, Jim4 aut
700	1	a Overs, Bronwyn J.4 aut
700	1	a Ozerdem, Aysegul4 aut
700	1	a Pergola, Giulio4 aut
700	1	a Picchioni, Marco M.4 aut
700	1	a Piguet, Camille4 aut
700	1	a Pomarol-Clotet, Edith4 aut
700	1	a Radua, Joaquimu Karolinska Institutet4 aut
700	1	a Ramsay, Ian S.4 aut
700	1	a Richter, Anja4 aut
700	1	a Roberts, Gloria4 aut
700	1	a Salvador, Raymond4 aut
700	1	a Saricicek Aydogan, Aybala4 aut
700	1	a Sarró, Salvador4 aut
700	1	a Schofield, Peter R.4 aut
700	1	a Simsek, Esma M.4 aut
700	1	a Simsek, Fatma4 aut
700	1	a Soares, Jair C.4 aut
700	1	a Sponheim, Scott R.4 aut
700	1	a Sugranyes, Gisela4 aut
700	1	a Toulopoulou, Timothea4 aut
700	1	a Tronchin, Giulia4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Walter, Henrik4 aut
700	1	a Weinberger, Daniel R.4 aut
700	1	a Whalley, Heather C.4 aut
700	1	a Wu, Mon-Ju4 aut
700	1	a Yalin, Nefize4 aut
700	1	a Andreassen, Ole A.4 aut
700	1	a Ching, Christopher R. K.4 aut
700	1	a Thomopoulos, Sophia I.4 aut
700	1	a van Erp, Theo G. M.4 aut
700	1	a Jahanshad, Neda4 aut
700	1	a Thompson, Paul M.4 aut
700	1	a Kahn, René S.4 aut
700	1	a van Haren, Neeltje E. M.4 aut
710	2	a Karolinska Institutet4 org
773	0	t Human Brain Mappingd : John Wiley & Sonsg 43:1, s. 414-430q 43:1<414-430x 1065-9471x 1097-0193
856	4	u https://doi.org/10.1002/hbm.25206y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1748794/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25206
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206299
856	4 8	u https://doi.org/10.1002/hbm.25206
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:144823895

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Av författaren/redakt...: de Zwarte, Sonja ...; Brouwer, Rachel ...; Agartz, Ingrid; Alda, Martin; Alonso-Lana, Sil ...; Bearden, Carrie ...; visa fler...; Bertolino, Aless ...; Bonvino, Aurora; Bramon, Elvira; Buimer, Elizabet ...; Cahn, Wiepke; Canales-Rodrígue ...; Cannon, Dara M.; Cannon, Tyrone D ...; Caseras, Xavier; Castro-Fornieles ...; Chen, Qiang; Chung, Yoonho; De la Serna, Ele ...; Del Mar Bonnin, ...; Demro, Caroline; Di Giorgio, Anna ...; Doucet, Gaelle E ...; Eker, Mehmet Cag ...; Erk, Susanne; Fatjó-Vilas, Mar; Fears, Scott C.; Foley, Sonya F.; Frangou, Sophia; Fullerton, Janic ...; Glahn, David C.; Goghari, Vina M.; Goikolea, Jose M ...; Goldman, Aaron L ...; Gonul, Ali Saffe ...; Gruber, Oliver; Hajek, Tomas; Hawkins, Emma L.; Heinz, Andreas; Hidiroglu Ongun, ...; Hillegers, Manon ...; Houenou, Josseli ...; Hulshoff Pol, Hi ...; Hultman, Christi ...; Ingvar, Martin; Johansson, Vikto ...; Jönsson, Erik G.; Kane, Fergus; Kempton, Matthew ...; Koenis, Marinka ...; Kopecek, Milosla ...; Krämer, Bernd; Lawrie, Stephen ...; Lenroot, Rhoshel ...; Marcelis, Machte ...; Mattay, Venkata ...; McDonald, Colm; Meyer-Lindenberg ...; Michielse, Stijn; Mitchell, Philip ...; Moreno, Dolores; Murray, Robin M.; Mwangi, Benson; Nabulsi, Leila; Newport, Jason; Olman, Cheryl A.; van Os, Jim; Overs, Bronwyn J ...; Ozerdem, Aysegul; Pergola, Giulio; Picchioni, Marco ...; Piguet, Camille; Pomarol-Clotet, ...; Radua, Joaquim; Ramsay, Ian S.; Richter, Anja; Roberts, Gloria; Salvador, Raymon ...; Saricicek Aydoga ...; Sarró, Salvador; Schofield, Peter ...; Simsek, Esma M.; Simsek, Fatma; Soares, Jair C.; Sponheim, Scott ...; Sugranyes, Gisel ...; Toulopoulou, Tim ...; Tronchin, Giulia; Vieta, Eduard; Walter, Henrik; Weinberger, Dani ...; Whalley, Heather ...; Wu, Mon-Ju; Yalin, Nefize; Andreassen, Ole ...; Ching, Christoph ...; Thomopoulos, Sop ...; van Erp, Theo G. ...; Jahanshad, Neda; Thompson, Paul M ...; Kahn, René S.; van Haren, Neelt ...; visa färre...

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