Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors

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Fältnamn	Indikatorer	Metadata
000		04565naa a2200625 4500
001		oai:gup.ub.gu.se/243167
003		SwePub
008		240910s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2431672 URI
024	7	a https://doi.org/10.1186/s12879-016-1648-22 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Backhaus, Eriku Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut
245	1 0	a Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors
264		c 2016-08-03
264	1	b Springer Science and Business Media LLC,c 2016
338		a electronic2 rdacarrier
520		a Background: Incidence, manifestations and case-fatality rate (CFR) of invasive pneumococcal disease (IPD) vary with age and comorbidities. New vaccines, changing age distribution, prolonged survival among immunocompromised patients and improved sepsis management have created a need for an update of basic facts to inform vaccine recommendations. Methods: Age, gender and comorbidities were related to manifestations and death for 2977 consecutive patients with IPD in a Swedish region with 1.5 million inhabitants during 13 years before introduction of pneumococcal conjugate vaccines (PCV) in the infant vaccination program. These data were related to population statistics and prevalence of several comorbidities, and compared with two previous studies giving a total follow-up of 45 years in the same area. Results: The annual incidence was 15/100,000 for any IPD and 1.1/100,000 for meningitis; highest among elderly followed by children < 2 years. It was 2238/100,000 among myeloma patients, followed by chronic lymphatic leukemia, hemodialysis and lung cancer, but not elevated among asthma patients. CFR was 10 % among all patients, varying from 3 % below 18 years to 22 %>= 80 years. During 45 years, the IPD incidence increased threefold and CFR dropped from 20 to 10 %. Meningitis incidence remained stable (1.1/100,000/year) but CFR dropped from 33 to 13 %. IPD-specific mortality decreased among children < 2 years from 3.1 to 0.46/100,000/year but tripled among those >= 65 years. Conclusions: IPD incidence and CFR vary widely between age and risk groups and over time even without general infant vaccination. Knowledge about specific epidemiological characteristics is important for informing and evaluating vaccination policies.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653		a Streptococcus pneumoniae
653		a Pneumococcal disease
653		a Meningitis
653		a Incidence
653		a Manifestations
653		a IMMUNIZATION PRACTICES ACIP
653		a STREPTOCOCCUS-PNEUMONIAE
653		a CONJUGATE
653		a VACCINE
653		a POLYSACCHARIDE VACCINE
653		a UNDETERMINED SIGNIFICANCE
653		a MONOCLONAL
653		a GAMMOPATHY
653		a ADVISORY-COMMITTEE
653		a MULTIPLE-MYELOMA
653		a DISEASE
653		a ADULTS
700	1	a Berg, S.4 aut
700	1	a Andersson, Rune,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xandru
700	1	a Ockborn, G.4 aut
700	1	a Malmstrom, P.4 aut
700	1	a Dahl, M.4 aut
700	1	a Nasic, S.4 aut
700	1	a Trollfors, B.4 aut
710	2	a Göteborgs universitetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org
773	0	t Bmc Infectious Diseasesd : Springer Science and Business Media LLCg 16q 16x 1471-2334
856	4	u https://gup.ub.gu.se/publication/243167x primaryx freey FULLTEXT
856	4	u https://doi.org/10.1186/s12879-016-1648-2
856	4 8	u https://gup.ub.gu.se/publication/243167
856	4 8	u https://doi.org/10.1186/s12879-016-1648-2

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Av författaren/redakt...: Backhaus, Erik; Berg, S.; Andersson, Rune, ...; Ockborn, G.; Malmstrom, P.; Dahl, M.; visa fler...; Nasic, S.; Trollfors, B.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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