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  • Hägg, Daniel,1974Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg (author)

Oxidized LDL induces a coordinated up-regulation of the glutathione and thioredoxin systems in human macrophages.

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Elsevier BV,2006

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/119543
  • https://gup.ub.gu.se/publication/119543URI
  • https://doi.org/10.1016/j.atherosclerosis.2005.06.034DOI
  • https://research.chalmers.se/publication/119543URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Using DNA microarray analysis, we found that human macrophages respond to oxidized low-density lipoprotein (oxLDL) by activating the antioxidative glutathione and thioredoxin systems. Several genes of the glutathione and thioredoxin systems were expressed at high levels in macrophages when compared to 80 other human tissues and cell types, indicating that these systems may be of particular importance in macrophages. The up-regulation of three genes in these systems, thioredoxin (P < 0.005), thioredoxin reductase 1 (P < 0.001) and glutathione reductase (P < 0.001) was verified with real-time RT-PCR, using human macrophages from 10 healthy donors. To investigate the possible role of these antioxidative systems in the development of atherosclerosis, expression levels in macrophages from 15 subjects with atherosclerosis (12 men, 3 women) and 15 matched controls (12 men, 3 women) were analyzed using DNA microarrays. Two genes in the glutathione system Mn superoxide dismutase (P < 0.05) and catalase (P < 0.05) differed in expression between the groups. We conclude that macrophage uptake of oxidized LDL induces a coordinated up-regulation of genes of the glutathione and thioredoxin systems, suggesting that these systems may participate in the cellular defense against oxidized LDL and possibly modulate the development of atherosclerosis.

Subject headings and genre

  • Atherosclerosis
  • genetics
  • metabolism
  • Female
  • Gene Expression
  • Glutathione
  • genetics
  • metabolism
  • Humans
  • Lipoproteins
  • LDL
  • pharmacology
  • Macrophages
  • metabolism
  • Male
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis
  • Oxidation-Reduction
  • Oxidative Stress
  • Pentose Phosphate Pathway
  • Reverse Transcriptase Polymerase Chain Reaction
  • Thioredoxins
  • genetics
  • metabolism
  • Up-Regulation
  • metabolism

Added entries (persons, corporate bodies, meetings, titles ...)

  • Englund, Mikael C. O.,1971Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg (author)
  • Jernås, Margareta,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xjernm (author)
  • Schmidt, Caroline,1966Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xschca (author)
  • Wiklund, Olov,1943Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xwikol (author)
  • Mattsson Hultén, Lillemor,1951Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xmatli (author)
  • Ohlsson, Bertil,1954Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xohlbe (author)
  • Carlsson, Lena M S,1957Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xcarle (author)
  • Carlsson, Björn,1958Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,University of Gothenburg(Swepub:gu)xcarbj (author)
  • Svensson, Per-Arne,1969Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory,University of Gothenburg(Swepub:gu)xsvper (author)
  • Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin (creator_code:org_t)

Related titles

  • In:Atherosclerosis: Elsevier BV185:2, s. 282-90021-91501879-1484

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