Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

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Fältnamn	Indikatorer	Metadata
000		06992naa a2201465 4500
001		oai:lup.lub.lu.se:00e89a10-7f60-4524-a7d1-d2ac0ae49eeb
003		SwePub
008		160401s2008 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/12051412 URI
024	7	a https://doi.org/10.1038/ng.1202 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Zeggini, Eleftheria4 aut
245	1 0	a Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
264		c 2008-03-30
264	1	b Springer Science and Business Media LLC,c 2008
520		a Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D)(1-11). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and similar to 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P=5.0 x 10(-14)), CDC123-CAMK1D (P=1.2 x 10(-10)), TSPAN8-LGR5 (P=1.1 x 10(-9)), THADA (P=1.1 x 10(-9)), ADAMTS9 (P=1.2 x 10(-8)) and NOTCH2 (P=4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Scott, Laura J.4 aut
700	1	a Saxena, Richa4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Marchini, Jonathan L.4 aut
700	1	a Hu, Tianle4 aut
700	1	a de Bakker, Paul I. W.4 aut
700	1	a Abecasis, Goncalo R.4 aut
700	1	a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal
700	1	a Andersen, Gitte4 aut
700	1	a Ardlie, Kristin4 aut
700	1	a Bostroem, Kristina Bengtsson4 aut
700	1	a Bergman, Richard N.4 aut
700	1	a Bonnycastle, Lori L.4 aut
700	1	a Borch-Johnsen, Knut4 aut
700	1	a Burtt, Noel P.4 aut
700	1	a Chen, Hong4 aut
700	1	a Chines, Peter S.4 aut
700	1	a Daly, Mark J.4 aut
700	1	a Deodhar, Parimal4 aut
700	1	a Ding, Chia-Jen4 aut
700	1	a Doney, Alex S. F.4 aut
700	1	a Duren, William L.4 aut
700	1	a Elliott, Katherine S.4 aut
700	1	a Erdos, Michael R.4 aut
700	1	a Frayling, Timothy M.4 aut
700	1	a Freathy, Rachel M.4 aut
700	1	a Gianniny, Lauren4 aut
700	1	a Grallert, Harald4 aut
700	1	a Grarup, Niels4 aut
700	1	a Groves, Christopher J.4 aut
700	1	a Guiducci, Candace4 aut
700	1	a Hansen, Torben4 aut
700	1	a Herder, Christian4 aut
700	1	a Hitman, Graham A.4 aut
700	1	a Hughes, Thomas E.4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Jackson, Anne U.4 aut
700	1	a Jorgensen, Torben4 aut
700	1	a Kong, Augustine4 aut
700	1	a Kubalanza, Kari4 aut
700	1	a Kuruvilla, Finny G.4 aut
700	1	a Kuusisto, Johanna4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Lango, Hana4 aut
700	1	a Lauritzen, Torsten4 aut
700	1	a Li, Yun4 aut
700	1	a Lindgren, Cecilia M.4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Marvelle, Amanda F.4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Midthjell, Kristian4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Morken, Mario A.4 aut
700	1	a Morris, Andrew D.4 aut
700	1	a Narisu, Narisu4 aut
700	1	a Nilsson, Peter4 aut
700	1	a Owen, Katharine R.4 aut
700	1	a Palmer, Colin N. A.4 aut
700	1	a Payne, Felicity4 aut
700	1	a Perry, John R. B.4 aut
700	1	a Pettersen, Elin4 aut
700	1	a Platou, Carl4 aut
700	1	a Prokopenko, Inga4 aut
700	1	a Qi, Lu4 aut
700	1	a Qin, Li4 aut
700	1	a Rayner, Nigel W.4 aut
700	1	a Rees, Matthew4 aut
700	1	a Roix, Jeffrey J.4 aut
700	1	a Sandbaek, Anelli4 aut
700	1	a Shields, Beverley4 aut
700	1	a Sjögren, Marketau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-msj
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Stringham, Heather M.4 aut
700	1	a Swift, Amy J.4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Timpson, Nicholas J.4 aut
700	1	a Tuomi, Tiinamaija4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Walker, Mark4 aut
700	1	a Watanabe, Richard M.4 aut
700	1	a Weedon, Michael N.4 aut
700	1	a Willer, Cristen J.4 aut
700	1	a Illig, Thomas4 aut
700	1	a Hveem, Kristian4 aut
700	1	a Hu, Frank B.4 aut
700	1	a Laakso, Markku4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Pedersen, Oluf4 aut
700	1	a Wareham, Nicholas J.4 aut
700	1	a Barroso, Ines4 aut
700	1	a Hattersley, Andrew T.4 aut
700	1	a Collins, Francis S.4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a McCarthy, Mark I.4 aut
700	1	a Boehnke, Michael4 aut
700	1	a Altshuler, David4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 40:5, s. 638-645q 40:5<638-645x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.120y FULLTEXT
856	4	u https://europepmc.org/articles/pmc2672416?pdf=render
856	4 8	u https://lup.lub.lu.se/record/1205141
856	4 8	u https://doi.org/10.1038/ng.120

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Av författaren/redakt...: Zeggini, Elefthe ...; Scott, Laura J.; Saxena, Richa; Voight, Benjamin ...; Marchini, Jonath ...; Hu, Tianle; visa fler...; de Bakker, Paul ...; Abecasis, Goncal ...; Almgren, Peter; Andersen, Gitte; Ardlie, Kristin; Bostroem, Kristi ...; Bergman, Richard ...; Bonnycastle, Lor ...; Borch-Johnsen, K ...; Burtt, Noel P.; Chen, Hong; Chines, Peter S.; Daly, Mark J.; Deodhar, Parimal; Ding, Chia-Jen; Doney, Alex S. F ...; Duren, William L ...; Elliott, Katheri ...; Erdos, Michael R ...; Frayling, Timoth ...; Freathy, Rachel ...; Gianniny, Lauren; Grallert, Harald; Grarup, Niels; Groves, Christop ...; Guiducci, Candac ...; Hansen, Torben; Herder, Christia ...; Hitman, Graham A ...; Hughes, Thomas E ...; Isomaa, Bo; Jackson, Anne U.; Jorgensen, Torbe ...; Kong, Augustine; Kubalanza, Kari; Kuruvilla, Finny ...; Kuusisto, Johann ...; Langenberg, Clau ...; Lango, Hana; Lauritzen, Torst ...; Li, Yun; Lindgren, Cecili ...; Lyssenko, Valeri ...; Marvelle, Amanda ...; Meisinger, Chris ...; Midthjell, Krist ...; Mohlke, Karen L.; Morken, Mario A.; Morris, Andrew D ...; Narisu, Narisu; Nilsson, Peter; Owen, Katharine ...; Palmer, Colin N. ...; Payne, Felicity; Perry, John R. B ...; Pettersen, Elin; Platou, Carl; Prokopenko, Inga; Qi, Lu; Qin, Li; Rayner, Nigel W.; Rees, Matthew; Roix, Jeffrey J.; Sandbaek, Anelli; Shields, Beverle ...; Sjögren, Marketa; Steinthorsdottir ...; Stringham, Heath ...; Swift, Amy J.; Thorleifsson, Gu ...; Thorsteinsdottir ...; Timpson, Nichola ...; Tuomi, Tiinamaij ...; Tuomilehto, Jaak ...; Walker, Mark; Watanabe, Richar ...; Weedon, Michael ...; Willer, Cristen ...; Illig, Thomas; Hveem, Kristian; Hu, Frank B.; Laakso, Markku; Stefansson, Kari; Pedersen, Oluf; Wareham, Nichola ...; Barroso, Ines; Hattersley, Andr ...; Collins, Francis ...; Groop, Leif; McCarthy, Mark I ...; Boehnke, Michael; Altshuler, David; visa färre...

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