What's normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically

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What's normal? Oligosaccharide concentrations and profiles in milk produced by healthy women vary geographically

McGuire, Michelle K. (author): Washington State University

Meehan, Courtney L. (author): Washington State University

McGuire, Mark A. (author): University of Idaho

Williams, Janet E. (author): University of Idaho

Foster, James (author): University of Idaho

Sellen, Daniel W. (author): University of Toronto

Kamau-Mbuthia, Elizabeth W. (author): Egerton University

Kamundia, Egidioh W. (author): Egerton University

Mbugua, Samwel (author): Egerton University

Moore, Sophie E. (author): MRC Human Nutrition Research,King's College London

Prentice, Andrew M. (author): MRC Human Nutrition Research

Kvist, Linda J. (author): Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups

Otoo, Gloria E. (author): University of Ghana

Brooker, Sarah L. (author): University of Idaho

Price, William J. (author): University of Idaho

Shafii, Bahman (author): University of Idaho

Placek, Caitlyn (author): Washington State University,Florida International University

Lackey, Kimberly A. (author): Washington State University

Robertson, Bianca (author): University of California, San Diego

Manzano, Susana (author): Complutense University of Madrid

Ruíz, Lorena (author): Complutense University of Madrid

Rodríguez, Juan M. (author): Complutense University of Madrid

Pareja, Rossina G. (author)

Bode, Lars (author): University of California, San Diego

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(creator_code:org_t)

Elsevier BV, 2017
2017
English 15 s.
In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165. ; 105:5, s. 1086-1100

Related links:: http://dx.doi.org/10... (free); show more...; https://academic.oup...; https://lup.lub.lu.s...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Human milk is a complex fluid comprised of myriad substances, with one of the most abundant substances being a group of complex carbohydrates referred to as human milk oligosaccharides (HMOs). There has been some evidence that HMO profiles differ in populations, but few studies have rigorously explored this variability. Objectives: We tested the hypothesis that HMO profiles differ in diverse populations of healthy women. Next, we examined relations between HMO and maternal anthropometric and reproductive indexes and indirectly examined whether differences were likely related to genetic or environmental variations. Design: In this cross-sectional, observational study, milk was collected from a total of 410 healthy, breastfeeding women in 11 international cohorts and analyzed for HMOs by using high-performance liquid chromatography. Results: There was an effect of the cohort (P , 0.05) on concentrations of almost all HMOs. For instance, the mean 3-fucosyllactose concentration was .4 times higher in milk collected in Sweden than in milk collected in rural Gambia (mean ± SEM: 473 6 55 compared with 103 6 16 μmol/mL, respectively; P , 0.05), and disialyllacto-N-tetraose (DSLNT) concentrations ranged from 216 ± 14 μmol/mL (in Sweden) to 870 ± 68 μmol/mL (in rural Gambia) (P , 0.05). Maternal age, time postpartum, weight, and body mass index were all correlated with several HMOs, and multiple differences in HMOs [e.g., lacto-N-neotetrose and DSLNT] were shown between ethnically similar (and likely genetically similar) populations who were living in different locations, which suggests that the environment may play a role in regulating the synthesis of HMOs. Conclusions: The results of this study support our hypothesis that normal HMO concentrations and profiles vary geographically, even in healthy women. Targeted genomic analyses are required to determine whether these differences are due at least in part to genetic variation. A careful examination of sociocultural, behavioral, and environmental factors is needed to determine their roles in this regard. This study was registered at clinicaltrials.gov as NCT02670278.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Keyword

Breastfeeding
Carbohydrates
Human milk
Lactation
Oligosaccharides

Publication and Content Type

art (subject category)
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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

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