Sökning: WFRF:(Demissie A) > Common variants at ...
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000 | 05511naa a2201045 4500 | |
001 | oai:lup.lub.lu.se:3bda50e8-bbd1-4784-a049-cf6d1364419b | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/13131382 URI |
024 | 7 | a https://doi.org/10.1038/ng.2912 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Kathiresan, Sekar4 aut |
245 | 1 0 | a Common variants at 30 loci contribute to polygenic dyslipidemia |
264 | c 2008-12-07 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
520 | a Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Willer, Cristen J.4 aut |
700 | 1 | a Peloso, Gina M.4 aut |
700 | 1 | a Demissie, Serkalem4 aut |
700 | 1 | a Musunuru, Kiran4 aut |
700 | 1 | a Schadt, Eric E.4 aut |
700 | 1 | a Kaplan, Lee4 aut |
700 | 1 | a Bennett, Derrick4 aut |
700 | 1 | a Li, Yun4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Voight, Benjamin F.4 aut |
700 | 1 | a Bonnycastle, Lori L.4 aut |
700 | 1 | a Jackson, Anne U.4 aut |
700 | 1 | a Crawford, Gabriel4 aut |
700 | 1 | a Surti, Aarti4 aut |
700 | 1 | a Guiducci, Candace4 aut |
700 | 1 | a Burtt, Noel P.4 aut |
700 | 1 | a Parish, Sarah4 aut |
700 | 1 | a Clarke, Robert4 aut |
700 | 1 | a Zelenika, Diana4 aut |
700 | 1 | a Kubalanza, Kari A.4 aut |
700 | 1 | a Morken, Mario A.4 aut |
700 | 1 | a Scott, Laura J.4 aut |
700 | 1 | a Stringham, Heather M.4 aut |
700 | 1 | a Galan, Pilar4 aut |
700 | 1 | a Swift, Amy J.4 aut |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Bergman, Richard N.4 aut |
700 | 1 | a Sundvall, Jouko4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Scheet, Paul4 aut |
700 | 1 | a Sanna, Serena4 aut |
700 | 1 | a Uda, Manuela4 aut |
700 | 1 | a Yang, Qiong4 aut |
700 | 1 | a Lunetta, Kathryn L.4 aut |
700 | 1 | a Dupuis, Josee4 aut |
700 | 1 | a de Bakker, Paul I. W.4 aut |
700 | 1 | a O'Donnell, Christopher J.4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Hercberg, Serge4 aut |
700 | 1 | a Meneton, Pierre4 aut |
700 | 1 | a Lakatta, Edward G.4 aut |
700 | 1 | a Scuteri, Angelo4 aut |
700 | 1 | a Schlessinger, David4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Collins, Francis S.4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Collins, Rory4 aut |
700 | 1 | a Lathrop, G. Mark4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Ordovas, Jose M.4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Abecasis, Goncalo R.4 aut |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 41:1, s. 56-65q 41:1<56-65x 1546-1718x 1061-4036 |
856 | 4 | u http://dx.doi.org/10.1038/ng.291y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc2881676?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/1313138 |
856 | 4 8 | u https://doi.org/10.1038/ng.291 |
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