Sökning: WFRF:(Harris Robert A) > (2020-2024) > Altered perivascula...
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000 | 08248naa a2200817 4500 | |
001 | oai:DiVA.org:umu-182762 | |
003 | SwePub | |
008 | 210511s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:kth-295441 | |
009 | oai:prod.swepub.kib.ki.se:146460728 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1827622 URI |
024 | 7 | a https://doi.org/10.1038/s41591-021-01295-92 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2954412 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464607282 URI |
040 | a (SwePub)umud (SwePub)kthd (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Månberg, Anna,d 1985-u KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1g5roxd |
245 | 1 0 | a Altered perivascular fibroblast activity precedes ALS disease onset |
264 | c 2021-04-15 | |
264 | 1 | b Nature Publishing Group,c 2021 |
338 | a print2 rdacarrier | |
500 | a Publisher Correction:Månberg, A., Skene, N., Sanders, F. et al. Publisher Correction: Altered perivascular fibroblast activity precedes ALS disease onset. Nat Med 27, 1308 (2021). DOI: 10.1038/s41591-021-01414-6 | |
500 | a QC 20210621 | |
520 | a Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study we use an expression-weighted cell-type enrichment method to infer cell activity in spinal cord samples from patients with sporadic ALS and mouse models of this disease. Here we report that patients with sporadic ALS present cell activity patterns consistent with two mouse models in which enrichments of vascular cell genes preceded microglial response. Notably, during the presymptomatic stage, perivascular fibroblast cells showed the strongest gene enrichments, and their marker proteins SPP1 and COL6A1 accumulated in enlarged perivascular spaces in patients with sporadic ALS. Moreover, in plasma of 574 patients with ALS from four independent cohorts, increased levels of SPP1 at disease diagnosis repeatedly predicted shorter survival with stronger effect than the established risk factors of bulbar onset or neurofilament levels in cerebrospinal fluid. We propose that the activity of the recently discovered perivascular fibroblast can predict survival of patients with ALS and provide a new conceptual framework to re-evaluate definitions of ALS etiology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Skene, Nathanu Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden; Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom; United Kingdom Dementia Research Institute, London, United Kingdom4 aut |
700 | 1 | a Sanders, Folkertu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut |
700 | 1 | a Trusohamn, Martau Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden4 aut |
700 | 1 | a Remnestål, Juliau KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u13wztpi |
700 | 1 | a Szczepińska, Annau Karolinska Institutet4 aut |
700 | 1 | a Aksoylu, Inci Sevvalu Karolinska Institutet4 aut |
700 | 1 | a Lönnerberg, Peteru Karolinska Institutet4 aut |
700 | 1 | a Ebarasi, Lwakiu Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden4 aut |
700 | 1 | a Wouters, Stefanu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut |
700 | 1 | a Lehmann, Manuelau Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)male0080 |
700 | 1 | a Olofsson, Jennieu KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1q8hz5k |
700 | 1 | a von Gohren Antequera, Intiu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut |
700 | 1 | a Domaniku, Aylinu Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut |
700 | 1 | a De Schaepdryver, Maximu Laboratory for Neurobiomarker Research, Department of Neurology, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium4 aut |
700 | 1 | a De Vocht, Jokeu Neurology Department and Center for Brain & Disease Research, KU Leuven, VIB, Leuven, Belgium4 aut |
700 | 1 | a Poesen, Koenu Laboratory for Neurobiomarker Research, Department of Neurology, Leuven Brain Institute, KU Leuven (University of Leuven), Leuven, Belgium; Laboratory Medicine, UZ Leuven (University Hospital Leuven), Leuven, Belgium4 aut |
700 | 1 | a Uhlén, Mathiasu KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.4 aut0 (Swepub:kth)u1dulvmw |
700 | 1 | a Anink, Jasperu Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands4 aut |
700 | 1 | a Mijnsbergen, Carolineu Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands4 aut |
700 | 1 | a Vergunst-Bosch, Hermienekeu UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, Netherlands4 aut |
700 | 1 | a Hübers, Annemarieu University of Ulm, Neurology Clinic, Ulm, Germany; Division of Neurology, Geneva University Hospital, Geneva, Switzerland4 aut |
700 | 1 | a Kläppe, Ulfu Karolinska Institutet4 aut |
700 | 1 | a Rodriguez-Vieitez, Elenau Karolinska Institutet4 aut |
700 | 1 | a Gilthorpe, Jonathan D.u Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut0 (Swepub:umu)jogi0002 |
700 | 1 | a Hedlund, Evau Karolinska Institutet4 aut |
700 | 1 | a Harris, Robert A.u Karolinska Institutet4 aut |
700 | 1 | a Aronica, Eleonorau Department of (Neuro)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam, Netherlands4 aut |
700 | 1 | a Van Damme, Philipu Neurology Department and Center for Brain & Disease Research, KU Leuven, VIB, Leuven, Belgium4 aut |
700 | 1 | a Ludolph, Albertu University of Ulm, Neurology Clinic, Ulm, Germany; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ulm, Bonn, Germany4 aut |
700 | 1 | a Veldink, Janu UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, Netherlands4 aut |
700 | 1 | a Ingre, Carolineu Karolinska Institutet4 aut |
700 | 1 | a Nilsson, Peteru KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik4 aut0 (Swepub:kth)u1ws88sk |
700 | 1 | a Lewandowski, Sebastianu KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Clinical Neuroscience, Karolinska Institute, Centre for Molecular Medicine, Karolinska Hospital, Stockholm, Sweden4 aut0 (Swepub:kth)u1d4y8tu |
710 | 2 | a KTHb Science for Life Laboratory, SciLifeLab4 org |
773 | 0 | t Nature Medicined : Nature Publishing Groupg 27:4, s. 640-646q 27:4<640-646x 1078-8956x 1546-170X |
856 | 4 | u http://spiral.imperial.ac.uk/bitstream/10044/1/89868/2/output.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182762 |
856 | 4 8 | u https://doi.org/10.1038/s41591-021-01295-9 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-295441 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146460728 |
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