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Superselective endo...
Superselective endovascular tissue access using trans-vessel wall technique : feasibility study for treatment applications in heart, pancreas and kidney in swine
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- Grankvist, R. (författare)
- Karolinska Institutet
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- Jensen-Urstad, M. (författare)
- Karolinska Institutet
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- Clarke, J. (författare)
- Karolinska Inst, Dept Cell & Mol Biol & Med, Stockholm, Sweden.
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- Lehtinen, M. (författare)
- Karolinska Inst, Dept Cell & Mol Biol & Med, Stockholm, Sweden.
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- Little, P. (författare)
- Karolinska Institutet
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- Lundberg, J. (författare)
- Karolinska Institutet
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- Arnberg, F. (författare)
- Karolinska Institutet
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- Jonsson, Stefan (författare)
- KTH,Materialvetenskap,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Neuroradiol, S-17176 Stockholm, Sweden
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- Chien, K. R. (författare)
- Karolinska Institutet
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- Holmin, S. (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Cell & Mol Biol & Med, Stockholm, Sweden (creator_code:org_t)
- 2018-10-28
- 2019
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 285:4, s. 398-406
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Objectives. With the emergence of targeted cell transplantation and gene therapy, there is a need for minimally invasive tissue access to facilitate delivery of therapeutic substrate. The objective of this study was to demonstrate the suitability of an endovascular device which is able to directly access tissue and deliver therapeutic agent to the heart, kidney and pancreas without need to seal the penetration site. Methods. In vivo experiments were performed in 30 swine, including subgroups with follow-up to evaluate complications. The previously described trans-vessel wall (VW) device was modified to be sharper and not require tip detachment to seal the VW. Injections into targets in the heart (n = 13, 24-h follow-up n = 5, 72-h follow-up n = 3), kidney (n = 8, 14-day follow-up n = 3) and pancreas (n = 5) were performed. Some animals were used for multiple organ injections. Follow-up consisted of clinical monitoring, angiography and necropsy. Transvenous (in heart) and transarterial approaches (in heart, kidney and pancreas) were used. Injections were targeted towards the subepicardium, endomyocardium, pancreas head and tail, and kidney subcapsular space and cortex. Results. Injections were successful in target organs, visualized by intraparenchymal contrast on fluoroscopy and by necropsy. No serious complications (defined as heart failure or persistent arrhythmia, haemorrhage requiring treatment or acute kidney injury) were encountered over a total of 157 injections. Conclusions. The trans-VW device can achieve superselective injections to the heart, pancreas and kidney for delivery of therapeutic substances without tip detachment. All parts of these organs including the subepicardium, pancreas tail and renal subcapsular space can be efficiently reached.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Nyckelord
- gene therapy
- heart failure
- kidney
- pancreas
- stem cell transplantation
- cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Grankvist, R.
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Jensen-Urstad, M ...
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Clarke, J.
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Lehtinen, M.
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Little, P.
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Lundberg, J.
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visa fler...
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Arnberg, F.
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Jonsson, Stefan
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Chien, K. R.
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Holmin, S.
-
visa färre...
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