Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Lam Karen K.) > Large-scale associa...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		10962naa a2202125 4500
001		oai:DiVA.org:umu-137794
003		SwePub
008		170727s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:b5f6bb50-9652-4fb7-821f-5e126bc11baa
009		oai:prod.swepub.kib.ki.se:136091611
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1377942 URI
024	7	a https://doi.org/10.1038/ng.38922 DOI
024	7	a https://lup.lub.lu.se/record/b5f6bb50-9652-4fb7-821f-5e126bc11baa2 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360916112 URI
040		a (SwePub)umud (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a McKay, James D.u International Agency for Research on Cancer, World Health Organization4 aut
245	1 0	a Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
264		c 2017-06-12
264	1	b Nature Publishing Group,c 2017
338		a print2 rdacarrier
520		a Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Genome-wide association studies
653		a Lung cancer
653		a Transcriptomics
700	1	a Hung, Rayjean J.u University of Toronto4 aut
700	1	a Han, Younghunu Dartmouth College4 aut
700	1	a Zong, Xuchenu University of Toronto4 aut
700	1	a Carreras-Torres, Robertu International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Christiani, David C.u Harvard Medical School,Dartmouth College4 aut
700	1	a Caporaso, Neil E.u National Institutes of Health, United States4 aut
700	1	a Johansson, Mattiasu International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Xiao, Xiangjunu Karolinska Institutet4 aut
700	1	a Li, Yafangu Dartmouth College4 aut
700	1	a Byun, Jinyoungu Dartmouth College4 aut
700	1	a Dunning, Alisonu University of Cambridge4 aut
700	1	a Pooley, Karen A.u University of Cambridge4 aut
700	1	a Qian, David C.4 aut
700	1	a Ji, Xuemeiu Dartmouth College4 aut
700	1	a Liu, Geoffreyu University of Toronto4 aut
700	1	a Timofeeva, Maria N.u International Agency for Research on Cancer, World Health Organization4 aut
700	1	a Bojesen, Stig E.u Copenhagen University Hospital4 aut
700	1	a Wu, Xifengu University of Texas4 aut
700	1	a Le Marchand, Loicu University of Hawaii Cancer Center4 aut
700	1	a Albanes, Demetriosu National Institutes of Health, United States4 aut
700	1	a Bickeböller, Heikeu University of Göttingen4 aut
700	1	a Aldrich, Melinda C.u Vanderbilt University Medical Center4 aut
700	1	a Bush, William S.u Case Western Reserve University4 aut
700	1	a Tardon, Adoninau University of Oviedo4 aut
700	1	a Rennert, Gadu Carmel Medical Center4 aut
700	1	a Teare, M. Dawnu University of Sheffield4 aut
700	1	a Field, John K.u University of Liverpool4 aut
700	1	a Kiemeney, Lambertus A.u Radboud University Medical Center4 aut
700	1	a Lazarus, Philipu Washington State University4 aut
700	1	a Haugen, Aageu National Institute of Occupational Health, Norway4 aut
700	1	a Lam, Stephenu British Columbia Cancer Agency4 aut
700	1	a Schabath, Matthew B.u H. Lee Moffitt Cancer Center & Research Institute4 aut
700	1	a Andrew, Angeline S.u Dartmouth College4 aut
700	1	a Shen, Hongbingu Nanjing Medical University4 aut
700	1	a Hong, Yun-Chulu Seoul National University4 aut
700	1	a Yuan, Jian-Minu University of Pittsburgh Cancer Institute4 aut
700	1	a Bertazzi, Pier Albertou University of Milan4 aut
700	1	a Pesatori, Angela C.u University of Milan4 aut
700	1	a Ye, Yuanqingu University of Texas4 aut
700	1	a Diao, Nancyu Harvard T.H. Chan School of Public Health4 aut
700	1	a Su, Liu Harvard T.H. Chan School of Public Health4 aut
700	1	a Zhang, Ruyangu Harvard T.H. Chan School of Public Health4 aut
700	1	a Brhane, Yonathanu University of Toronto4 aut
700	1	a Leighl, Natashau Princess Margaret Hospital University of Toronto4 aut
700	1	a Johansen, Jakob S.u Copenhagen University Hospital4 aut
700	1	a Mellemgaard, Anders4 aut
700	1	a Saliba, Walid4 aut
700	1	a Haiman, Christopher A.4 aut
700	1	a Wilkens, Lynne R.4 aut
700	1	a Fernandez-Somoano, Ana4 aut
700	1	a Fernandez-Tardon, Guillermo4 aut
700	1	a van der Heijden, Henricus F. M.4 aut
700	1	a Kim, Jin Hee4 aut
700	1	a Dai, Juncheng4 aut
700	1	a Hu, Zhibin4 aut
700	1	a Davies, Michael P. A.4 aut
700	1	a Marcus, Michael W.4 aut
700	1	a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hsb
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Muller, David C.4 aut
700	1	a Overvad, Kim4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Doherty, Jennifer A.4 aut
700	1	a Barnett, Matt P.4 aut
700	1	a Chen, Chu4 aut
700	1	a Goodman, Gary E.4 aut
700	1	a Cox, Angela4 aut
700	1	a Taylor, Fiona4 aut
700	1	a Woll, Penella4 aut
700	1	a Brüske, Irene4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Manz, Judith4 aut
700	1	a Muley, Thomas R.4 aut
700	1	a Risch, Angela4 aut
700	1	a Rosenberger, Albert4 aut
700	1	a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
700	1	a Johansson, Mikaelu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)mijo0025
700	1	a Shepherd, Frances A.4 aut
700	1	a Tsao, Ming-Sound4 aut
700	1	a Arnold, Susanne M.4 aut
700	1	a Haura, Eric B.4 aut
700	1	a Bolca, Ciprian4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Kontic, Milica4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Mukeria, Anush4 aut
700	1	a Ognjanovic, Simona4 aut
700	1	a Orlowski, Tadeusz M.4 aut
700	1	a Scelo, Ghislaine4 aut
700	1	a Swiatkowska, Beata4 aut
700	1	a Zaridze, David4 aut
700	1	a Bakke, Per4 aut
700	1	a Skaug, Vidar4 aut
700	1	a Zienolddiny, Shanbeh4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Butler, Lesley M.4 aut
700	1	a Koh, Woon-Puay4 aut
700	1	a Gao, Yu-Tang4 aut
700	1	a Houlston, Richard S.4 aut
700	1	a McLaughlin, John4 aut
700	1	a Stevens, Victoria L.4 aut
700	1	a Joubert, Philippe4 aut
700	1	a Lamontagne, Maxime4 aut
700	1	a Nickle, David C.4 aut
700	1	a Obeidat, Ma'en4 aut
700	1	a Timens, Wim4 aut
700	1	a Zhu, Bin4 aut
700	1	a Song, Leiu National Institutes of Health, United States4 aut0 (Swepub:lu)med-ls1
700	1	a Kachuri, Linda4 aut
700	1	a Artigas, Maria Soler4 aut
700	1	a Tobin, Martin D.4 aut
700	1	a Wain, Louise V.4 aut
700	1	a Rafnar, Thorunn4 aut
700	1	a Thorgeirsson, Thorgeir E.4 aut
700	1	a Reginsson, Gunnar W.4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Hancock, Dana B.4 aut
700	1	a Bierut, Laura J.4 aut
700	1	a Spitz, Margaret R.4 aut
700	1	a Gaddis, Nathan C.4 aut
700	1	a Lutz, Sharon M.4 aut
700	1	a Gu, Fangyi4 aut
700	1	a Johnson, Eric O.4 aut
700	1	a Kamal, Ahsan4 aut
700	1	a Pikielny, Claudio4 aut
700	1	a Zhu, Dakai4 aut
700	1	a Lindström, Sara4 aut
700	1	a Jiang, Xia4 aut
700	1	a Tyndale, Rachel F.4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Beesley, Jonathan4 aut
700	1	a Bossé, Yohan4 aut
700	1	a Chanock, Stephen4 aut
700	1	a Brennan, Paul4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Amos, Christopher I.4 aut
710	2	a International Agency for Research on Cancer, World Health Organizationb University of Toronto4 org
710	2	a SpiroMeta Consortium
773	0	t Nature Geneticsd : Nature Publishing Groupg 49:7, s. 1126-1132q 49:7<1126-1132x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc5510465?pdf=render
856	4	u http://dx.doi.org/10.1038/ng.3892y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137794
856	4 8	u https://doi.org/10.1038/ng.3892
856	4 8	u https://lup.lub.lu.se/record/b5f6bb50-9652-4fb7-821f-5e126bc11baa
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:136091611

Hitta via bibliotek

Nature Genetics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: McKay, James D.; Hung, Rayjean J.; Han, Younghun; Zong, Xuchen; Carreras-Torres, ...; Christiani, Davi ...; visa fler...; Caporaso, Neil E ...; Johansson, Matti ...; Xiao, Xiangjun; Li, Yafang; Byun, Jinyoung; Dunning, Alison; Pooley, Karen A.; Qian, David C.; Ji, Xuemei; Liu, Geoffrey; Timofeeva, Maria ...; Bojesen, Stig E.; Wu, Xifeng; Le Marchand, Loi ...; Albanes, Demetri ...; Bickeböller, Hei ...; Aldrich, Melinda ...; Bush, William S.; Tardon, Adonina; Rennert, Gad; Teare, M. Dawn; Field, John K.; Kiemeney, Lamber ...; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthe ...; Andrew, Angeline ...; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A ...; Pesatori, Angela ...; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob ...; Mellemgaard, And ...; Saliba, Walid; Haiman, Christop ...; Wilkens, Lynne R ...; Fernandez-Somoan ...; Fernandez-Tardon ...; van der Heijden, ...; Kim, Jin Hee; Dai, Juncheng; Hu, Zhibin; Davies, Michael ...; Marcus, Michael ...; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, An ...; Tumino, Rosario; Doherty, Jennife ...; Barnett, Matt P.; Chen, Chu; Goodman, Gary E.; Cox, Angela; Taylor, Fiona; Woll, Penella; Brüske, Irene; Wichmann, H-Eric ...; Manz, Judith; Muley, Thomas R.; Risch, Angela; Rosenberger, Alb ...; Grankvist, Kjell; Johansson, Mikae ...; Shepherd, France ...; Tsao, Ming-Sound; Arnold, Susanne ...; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolan ...; Mukeria, Anush; Ognjanovic, Simo ...; Orlowski, Tadeus ...; Scelo, Ghislaine; Swiatkowska, Bea ...; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Sha ...; Duell, Eric J.; Butler, Lesley M ...; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richar ...; McLaughlin, John; Stevens, Victori ...; Joubert, Philipp ...; Lamontagne, Maxi ...; Nickle, David C.; Obeidat, Ma'en; Timens, Wim; Zhu, Bin; Song, Lei; Kachuri, Linda; Artigas, Maria S ...; Tobin, Martin D.; Wain, Louise V.; Rafnar, Thorunn; Thorgeirsson, Th ...; Reginsson, Gunna ...; Stefansson, Kari; Hancock, Dana B.; Bierut, Laura J.; Spitz, Margaret ...; Gaddis, Nathan C ...; Lutz, Sharon M.; Gu, Fangyi; Johnson, Eric O.; Kamal, Ahsan; Pikielny, Claudi ...; Zhu, Dakai; Lindström, Sara; Jiang, Xia; Tyndale, Rachel ...; Chenevix-Trench, ...; Beesley, Jonatha ...; Bossé, Yohan; Chanock, Stephen; Brennan, Paul; Landi, Maria Ter ...; Amos, Christophe ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Nature Genetics

Av lärosätet: Umeå universitet; Lunds universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se