WFRF:(Liu ZM)
Sökning: WFRF:(Liu ZM) > Osteoprotegerin Pro...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02808naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141896635 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1418966352 URI |
| 024 | 7 | a https://doi.org/10.2337/db18-10552 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhang, C4 aut |
| 245 | 1 0 | a Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK-PPAR-γ-CD36 Pathway |
| 264 | c 2019-07-10 | |
| 264 | 1 | b American Diabetes Association,c 2019 |
| 520 | a Previous cross-sectional studies have established that circulating osteoprotegerin (OPG) levels are associated with nonalcoholic fatty liver disease (NAFLD). However, the role of OPG in metabolic diseases, such as diabetes and NAFLD, is still unclear. In the current study, we demonstrated that hepatic OPG expression was downregulated in NAFLD individuals and in obese mice. OPG deficiency decreased lipid accumulation and expression of CD36 and peroxisome proliferator–activated receptor-γ (PPAR-γ) in the livers of OPG−/− mice and cultured cells, respectively, whereas OPG overexpression elicited the opposite effects. The stimulatory role of OPG in lipid accumulation was blocked by CD36 inactivation in hepatocytes isolated from CD36−/− mice. The overexpression of OPG led to a decrease in extracellular signal–regulated kinase (ERK) phosphorylation in the livers of OPG−/− mice and in cultured cells, while OPG deficiency resulted in the opposite effect. The inhibition of PPAR-γ or the activation of ERK blocked the induction of CD36 expression by OPG in cultured cells. Mechanistically, OPG facilitated CD36 expression by acting on PPAR response element (PPRE) present on the CD36 promoter. Taken together, our study revealed that OPG signaling promotes liver steatosis through the ERK–PPAR-γ–CD36 pathway. The downregulation of OPG in NAFLD might be a compensatory response of the body to dampen excess hepatic fat accumulation in obesity. | |
| 700 | 1 | a Luo, XH4 aut |
| 700 | 1 | a Chen, JR4 aut |
| 700 | 1 | a Zhou, BY4 aut |
| 700 | 1 | a Yang, ML4 aut |
| 700 | 1 | a Liu, R4 aut |
| 700 | 1 | a Liu, DF4 aut |
| 700 | 1 | a Gu, HF4 aut |
| 700 | 1 | a Zhu, ZM4 aut |
| 700 | 1 | a Zheng, HT4 aut |
| 700 | 1 | a Li, L4 aut |
| 700 | 1 | a Yang, GY4 aut |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 68:10, s. 1902-1914q 68:10<1902-1914x 1939-327Xx 0012-1797 |
| 856 | 4 | u https://diabetes.diabetesjournals.org/content/diabetes/68/10/1902.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141896635 |
| 856 | 4 8 | u https://doi.org/10.2337/db18-1055 |
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