Sökning: WFRF:(Power M.) > GWAS of Suicide Att...
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000 | 08053naa a2201717 4500 | |
001 | oai:DiVA.org:umu-164653 | |
003 | SwePub | |
008 | 191025s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:141795579 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1646532 URI |
024 | 7 | a https://doi.org/10.1176/appi.ajp.2019.180809572 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1417955792 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mullins, Niamh4 aut |
245 | 1 0 | a GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores |
264 | 1 | b American Psychiatric Association Publishing,c 2019 |
338 | a print2 rdacarrier | |
520 | a Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium.Methods: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders.Results: Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R2=0.25%), bipolar disorder (R2=0.24%), and schizophrenia (R2=0.40%).Conclusions: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Bigdeli, Tim B.4 aut |
700 | 1 | a Borglum, Anders D.4 aut |
700 | 1 | a Coleman, Jonathan R., I4 aut |
700 | 1 | a Demontis, Ditte4 aut |
700 | 1 | a Mehta, Divya4 aut |
700 | 1 | a Power, Robert A.4 aut |
700 | 1 | a Ripke, Stephan4 aut |
700 | 1 | a Stahl, Eli A.4 aut |
700 | 1 | a Starnawska, Anna4 aut |
700 | 1 | a Anjorin, Adebayo4 aut |
700 | 1 | a Corvin, Aiden4 aut |
700 | 1 | a Sanders, Alan R.4 aut |
700 | 1 | a Forstner, Andreas J.4 aut |
700 | 1 | a Reif, Andreas4 aut |
700 | 1 | a Koller, Anna C.4 aut |
700 | 1 | a Swiatkowska, Beata4 aut |
700 | 1 | a Baune, Bernhard T.4 aut |
700 | 1 | a Mueller-Myhsok, Bertram4 aut |
700 | 1 | a Penninx, Brenda W. J. H.4 aut |
700 | 1 | a Pato, Carlos4 aut |
700 | 1 | a Zai, Clement4 aut |
700 | 1 | a Rujescu, Dan4 aut |
700 | 1 | a Hougaard, David M.4 aut |
700 | 1 | a Quested, Digby4 aut |
700 | 1 | a Levinson, Douglas F.4 aut |
700 | 1 | a Binder, Elisabeth B.4 aut |
700 | 1 | a Byrne, Enda M.4 aut |
700 | 1 | a Agerbo, Esben4 aut |
700 | 1 | a Streit, Fabian4 aut |
700 | 1 | a Mayoral, Fermin4 aut |
700 | 1 | a Bellivier, Frank4 aut |
700 | 1 | a Degenhardt, Franziska4 aut |
700 | 1 | a Breen, Gerome4 aut |
700 | 1 | a Marken, Gunnar4 aut |
700 | 1 | a Turecki, Gustavo4 aut |
700 | 1 | a Rouleau, Guy A.4 aut |
700 | 1 | a Grabe, Hans J.4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Jones, Ian4 aut |
700 | 1 | a Giegling, Ina4 aut |
700 | 1 | a Agartz, Ingridu Karolinska Institutet4 aut |
700 | 1 | a Melle, Ingrid4 aut |
700 | 1 | a Lawrence, Jacob4 aut |
700 | 1 | a Walters, James T. R.4 aut |
700 | 1 | a Strohmaier, Jana4 aut |
700 | 1 | a Shi, Jianxin4 aut |
700 | 1 | a Hauser, Joanna4 aut |
700 | 1 | a Biernacka, Joanna M.4 aut |
700 | 1 | a Vincent, John B.4 aut |
700 | 1 | a Kelsoe, John4 aut |
700 | 1 | a Strauss, John S.4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Pimm, Jonathan4 aut |
700 | 1 | a Smoller, Jordan W.4 aut |
700 | 1 | a Guzman-Parra, Jose4 aut |
700 | 1 | a Berger, Klaus4 aut |
700 | 1 | a Scott, Laura J.4 aut |
700 | 1 | a Jones, Lisa A.4 aut |
700 | 1 | a Azevedo, M. Helena4 aut |
700 | 1 | a Trzaskowski, Maciej4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Rietschel, Marcella4 aut |
700 | 1 | a Boks, Marco4 aut |
700 | 1 | a Ising, Marcus4 aut |
700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
700 | 1 | a Hamshere, Marian L.4 aut |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Frye, Mark4 aut |
700 | 1 | a Noethen, Markus M.4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Preisig, Martin4 aut |
700 | 1 | a Nordentoft, Merete4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a O'Donovan, Michael C.4 aut |
700 | 1 | a Owen, Michael J.4 aut |
700 | 1 | a Pato, Michele T.4 aut |
700 | 1 | a Renteria, Miguel E.4 aut |
700 | 1 | a Budde, Monika4 aut |
700 | 1 | a Weissman, Myrna M.4 aut |
700 | 1 | a Wray, Naomi R.4 aut |
700 | 1 | a Bass, Nicholas4 aut |
700 | 1 | a Craddock, Nicholas4 aut |
700 | 1 | a Smeland, Olav B.4 aut |
700 | 1 | a Andreassen, Ole A.4 aut |
700 | 1 | a Mors, Ole4 aut |
700 | 1 | a Gejman, Pablo, V4 aut |
700 | 1 | a Sklar, Pamela4 aut |
700 | 1 | a McGrath, Patrick4 aut |
700 | 1 | a Hoffmann, Per4 aut |
700 | 1 | a McGuffin, Peter4 aut |
700 | 1 | a Lee, Phil H.4 aut |
700 | 1 | a Mortensen, Preben Bo4 aut |
700 | 1 | a Kahn, Rene S.4 aut |
700 | 1 | a Ophoff, Roel A.4 aut |
700 | 1 | a Adolfsson, Rolfu Umeå universitet,Psykiatri4 aut0 (Swepub:umu)road0001 |
700 | 1 | a Van Der Auwera, Sandra4 aut |
700 | 1 | a Djurovic, Srdjan4 aut |
700 | 1 | a Klaiber, Stefan4 aut |
700 | 1 | a Heilmann-Heimbach, Stefanie4 aut |
700 | 1 | a Jamain, Stephane4 aut |
700 | 1 | a Hamilton, Steven P.4 aut |
700 | 1 | a McElroy, Susan L.4 aut |
700 | 1 | a Lucae, Susanne4 aut |
700 | 1 | a Cichon, Sven4 aut |
700 | 1 | a Schulze, Thomas G.4 aut |
700 | 1 | a Hansen, Thomas4 aut |
700 | 1 | a Werge, Thomas4 aut |
700 | 1 | a Air, Tracy M.4 aut |
700 | 1 | a Nimgaonkar, Vishwajit4 aut |
700 | 1 | a Appadurai, Vivek4 aut |
700 | 1 | a Cahn, Wiepke4 aut |
700 | 1 | a Milaneschi, Yuri4 aut |
700 | 1 | a Fanous, Ayman H.4 aut |
700 | 1 | a Kendler, Kenneth S.4 aut |
700 | 1 | a McQuillin, Andrew4 aut |
700 | 1 | a Lewis, Cathryn M.4 aut |
710 | 2 | a Karolinska Institutetb Psykiatri4 org |
773 | 0 | t American Journal of Psychiatryd : American Psychiatric Association Publishingg 176:8, s. 651-660q 176:8<651-660x 0002-953Xx 1535-7228 |
856 | 4 | u https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2019.18080957 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164653 |
856 | 4 8 | u https://doi.org/10.1176/appi.ajp.2019.18080957 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141795579 |
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