The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

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Fältnamn	Indikatorer	Metadata
000		10933naa a2201933 4500
001		oai:DiVA.org:uu-206759
003		SwePub
008		130904s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:5ad70ca3-e840-4447-88b1-f702fdef0240
009		oai:prod.swepub.kib.ki.se:127098376
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2067592 URI
024	7	a https://doi.org/10.1371/journal.pmed.10014742 DOI
024	7	a https://lup.lub.lu.se/record/39752102 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1270983762 URI
040		a (SwePub)uud (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fall, Toveu Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878
245	1 0	a The Role of Adiposity in Cardiometabolic Traits :b A Mendelian Randomization Analysis
264		c 2013-06-25
264	1	b Public Library of Science (PLoS),c 2013
338		a electronic2 rdacarrier
500		a De fyra sista författarna delar sistaförfattarskapet.
520		a Background: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. Methods and Findings: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a Mendelian randomization design. Thirty-six population-based studies of individuals of European descent contributed to the analyses. Age-and sex-adjusted regression models were fitted to test for association between (i) rs9939609 and BMI (n = 198,502), (ii) rs9939609 and 24 traits, and (iii) BMI and 24 traits. The causal effect of BMI on the outcome measures was quantified by IV estimators. The estimators were compared to the BMI-trait associations derived from the same individuals. In the IV analysis, we demonstrated novel evidence for a causal relationship between adiposity and incident heart failure (hazard ratio, 1.19 per BMI-unit increase; 95% CI, 1.03-1.39) and replicated earlier reports of a causal association with type 2 diabetes, metabolic syndrome, dyslipidemia, and hypertension (odds ratio for IV estimator, 1.1-1.4; all p<0.05). For quantitative traits, our results provide novel evidence for a causal effect of adiposity on the liver enzymes alanine aminotransferase and gamma-glutamyl transferase and confirm previous reports of a causal effect of adiposity on systolic and diastolic blood pressure, fasting insulin, 2-h post-load glucose from the oral glucose tolerance test, C-reactive protein, triglycerides, and high-density lipoprotein cholesterol levels (all p<0.05). The estimated causal effects were in agreement with traditional observational measures in all instances except for type 2 diabetes, where the causal estimate was larger than the observational estimate (p = 0.001). Conclusions: We provide novel evidence for a causal relationship between adiposity and heart failure as well as between adiposity and increased liver enzymes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Hägg, Sarau Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)sarha464
700	1	a Maegi, Reedik4 aut
700	1	a Ploner, Alexanderu Karolinska Institutet4 aut
700	1	a Fischer, Krista4 aut
700	1	a Horikoshi, Momoko4 aut
700	1	a Sarin, Antti-Pekka4 aut
700	1	a Thorleifsson, Gudmar4 aut
700	1	a Ladenvall, Claesu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-cll
700	1	a Kals, Mart4 aut
700	1	a Kuningas, Maris4 aut
700	1	a Draisma, Harmen H. M.4 aut
700	1	a Ried, Janina S.4 aut
700	1	a van Zuydam, Natalie R.4 aut
700	1	a Huikari, Ville4 aut
700	1	a Mangino, Massimo4 aut
700	1	a Sonestedt, Emilyu Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso
700	1	a Benyamin, Beben4 aut
700	1	a Nelson, Christopher P.4 aut
700	1	a Rivera, Natalia V.4 aut
700	1	a Kristiansson, Kati4 aut
700	1	a Shen, Huei-yi4 aut
700	1	a Havulinna, Aki S.4 aut
700	1	a Dehghan, Abbas4 aut
700	1	a Donnelly, Louise A.4 aut
700	1	a Kaakinen, Marika4 aut
700	1	a Nuotio, Marja-Liisa4 aut
700	1	a Robertson, Neil4 aut
700	1	a de Bruijn, Renee F. A. G.4 aut
700	1	a Ikram, M. Arfan4 aut
700	1	a Amin, Najaf4 aut
700	1	a Balmforth, Anthony J.4 aut
700	1	a Braund, Peter S.4 aut
700	1	a Doney, Alexander S. F.4 aut
700	1	a Doering, Angela4 aut
700	1	a Elliott, Paul4 aut
700	1	a Esko, Tonu4 aut
700	1	a Franco, Oscar H.4 aut
700	1	a Gretarsdottir, Solveig4 aut
700	1	a Hartikainen, Anna-Liisa4 aut
700	1	a Heikkila, Kauko4 aut
700	1	a Herzig, Karl-Heinz4 aut
700	1	a Holm, Hilma4 aut
700	1	a Hottenga, Jouke Jan4 aut
700	1	a Hypponen, Elina4 aut
700	1	a Illig, Thomas4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Isomaa, Bo4 aut
700	1	a Karssen, Lennart C.4 aut
700	1	a Kettunen, Johannes4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Kuulasmaa, Kari4 aut
700	1	a Laatikainen, Tiina4 aut
700	1	a Laitinen, Jaana4 aut
700	1	a Lindgren, Cecilia4 aut
700	1	a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly
700	1	a Laara, Esa4 aut
700	1	a Rayner, Nigel W.4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Pouta, Anneli4 aut
700	1	a Rathmann, Wolfgang4 aut
700	1	a Rivadeneira, Fernando4 aut
700	1	a Ruokonen, Aimo4 aut
700	1	a Savolainen, Markku J.4 aut
700	1	a Sijbrands, Eric J. G.4 aut
700	1	a Small, Kerrin S.4 aut
700	1	a Smit, Jan H.4 aut
700	1	a Steinthorsdottir, Valgerdur4 aut
700	1	a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anncsyva
700	1	a Taanila, Anja4 aut
700	1	a Tobin, Martin D.4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a Willems, Sara M.4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Witteman, Jacqueline4 aut
700	1	a Perola, Markus4 aut
700	1	a Evans, Alun4 aut
700	1	a Ferrieres, Jean4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Kee, Frank4 aut
700	1	a Tregouet, David-Alexandre4 aut
700	1	a Arveiler, Dominique4 aut
700	1	a Amouyel, Philippe4 aut
700	1	a Ferrario, Marco M.4 aut
700	1	a Brambilla, Paolo4 aut
700	1	a Hall, Alistair S.4 aut
700	1	a Heath, AndrewC.4 aut
700	1	a Madden, Pamela A. F.4 aut
700	1	a Martin, Nicholas G.4 aut
700	1	a Montgomery, Grant W.4 aut
700	1	a Whitfield, John B.4 aut
700	1	a Jula, Antti4 aut
700	1	a Knekt, Paul4 aut
700	1	a Oostra, Ben4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Penninx, Brenda W. J. H.4 aut
700	1	a Smith, George Davey4 aut
700	1	a Kaprio, Jaakko4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Gieger, Christian4 aut
700	1	a Peters, Annette4 aut
700	1	a Wichmann, H. -Erich4 aut
700	1	a Boomsma, Dorret I.4 aut
700	1	a de Geus, Eco J. C.4 aut
700	1	a Tuomi, TiinaMaija4 aut
700	1	a Power, Chris4 aut
700	1	a Hammond, Christopher J.4 aut
700	1	a Spector, Tim D.4 aut
700	1	a Lind, Larsu Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Palmer, Colin Neil Alexander4 aut
700	1	a Morris, Andrew D.4 aut
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Jarvelin, Marjo-Riitta4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Vartiainen, Erkki4 aut
700	1	a Hofman, Albert4 aut
700	1	a Ripatti, Samuli4 aut
700	1	a Metspalu, Andres4 aut
700	1	a Thorsteinsdottir, Unnur4 aut
700	1	a Stefansson, Kari4 aut
700	1	a Pedersen, Nancy L.4 aut
700	1	a McCarthy, Mark I.4 aut
700	1	a Ingelsson, Eriku Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425
700	1	a Prokopenko, Inga4 aut
710	2	a Uppsala universitetb Institutionen för medicinska vetenskaper4 org
773	0	t PLoS Medicined : Public Library of Science (PLoS)g 10:6, s. e1001474-q 10:6<e1001474-x 1549-1277x 1549-1676
856	4	u https://uu.diva-portal.org/smash/get/diva2:645396/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001474&type=printable
856	4	u https://portal.research.lu.se/files/2400793/4391330.pdfx primaryx freey FULLTEXT
856	4	u http://dx.doi.org/10.1371/journal.pmed.1001474x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206759
856	4 8	u https://doi.org/10.1371/journal.pmed.1001474
856	4 8	u https://lup.lub.lu.se/record/3975210
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:127098376

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