3D genomics across the tree of life reveals condensin II as a determinant of architecture type

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Fältnamn	Indikatorer	Metadata
000		11415naa a2201045 4500
001		oai:DiVA.org:uu-449355
003		SwePub
008		210723s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4493552 URI
024	7	a https://doi.org/10.1126/science.abe22182 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hoencamp, Claireu Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
245	1 0	a 3D genomics across the tree of life reveals condensin II as a determinant of architecture type
264	1	b American Association for the Advancement of Science (AAAS),c 2021
338		a print2 rdacarrier
500		a De fyra första författarna delar förstaförfattarskapet.
520		a We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.
650	7	a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng
700	1	a Dudchenko, Olgau Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.4 aut
700	1	a Elbatsh, Ahmed M. O.u Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.;Novartis Inst Biomed Res, CH-4002 Basel, Switzerland.4 aut
700	1	a Brahmachari, Sumitabhau Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.4 aut
700	1	a Raaijmakers, Jonne A.u Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a van Schaik, Tomu Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a Cacciatore, Angela Sedenou Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a Contessoto, Vinicius G.u Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;Sao Paulo State Univ UNESP, Inst Biosci Letters & Exact Sci, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil.4 aut
700	1	a van Heesbeen, Roy G. H. P.u Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands.;Janssen Vaccines & Prevent BV, NL-2333 CN Leiden, Netherlands.4 aut
700	1	a van den Broek, Bramu Netherlands Canc Inst, BioImaging Facil, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a Mhaskar, Aditya N.u Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.;Univ Med Ctr Rotterdam, Erasmus MC, Dept Dev Biol, NL-3015 GD Rotterdam, Netherlands.4 aut
700	1	a Teunissen, Hansu Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a St Hilaire, Brian Glennu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.4 aut
700	1	a Weisz, Davidu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.4 aut
700	1	a Omer, Arina D.u Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.4 aut
700	1	a Pham, Melanieu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.4 aut
700	1	a Colaric, Zaneu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.4 aut
700	1	a Yang, Zhenzhenu ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Pudong 201210, Peoples R China.4 aut
700	1	a Rao, Suhas S. P.u Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.4 aut
700	1	a Mitra, Namitau Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.4 aut
700	1	a Lui, Christopheru Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.4 aut
700	1	a Yao, Weijieu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.4 aut
700	1	a Khan, Ruqayyau Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.4 aut
700	1	a Moroz, Leonid L.u Univ Florida, Whitney Lab, Gainesville, FL 32611 USA.;Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA.4 aut
700	1	a Kohn, Andreau Univ Florida, Whitney Lab, Gainesville, FL 32611 USA.;Univ Florida, Dept Neurosci, Gainesville, FL 32611 USA.4 aut
700	1	a St Leger, Judyu Cornell Univ, Dept Biosci, Coll Vet Med, Ithaca, NY 14853 USA.4 aut
700	1	a Mena, Alexandriau SeaWorld San Diego, San Diego, CA 92109 USA.4 aut
700	1	a Holcroft, Karenu Moody Gardens, Galveston, TX 77554 USA.4 aut
700	1	a Gambetta, Maria Cristinau Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.4 aut
700	1	a Lim, Fabianu Univ Calif San Diego, Dept Med & Mol Biol, La Jolla, CA 92093 USA.4 aut
700	1	a Farley, Emmau Univ Calif San Diego, Dept Med & Mol Biol, La Jolla, CA 92093 USA.4 aut
700	1	a Stein, Nilsu Leibniz Inst Plant Genet & Crop Plant Res IPK Gat, D-06466 Seeland, Germany.;Georg August Univ Gottingen, Ctr Integrated Breeding Res CiBreed, Dept Crop Sci, D-37075 Gottingen, Germany.;Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia.4 aut
700	1	a Haddad, Alexanderu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.4 aut
700	1	a Chauss, Danielu NIDDK, NIH, Bethesda, MD 20892 USA.4 aut
700	1	a Mutlu, Ayse Senau Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.4 aut
700	1	a Wang, Meng C.u Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA.;Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA.4 aut
700	1	a Young, Neil D.u Univ Melbourne, Fac Vet & Agr Sci, Parkville, Vic 3010, Australia.4 aut
700	1	a Hildebrandt, Evinu ARS, Avian Dis & Oncol Lab, USDA, E Lansing, MI 48823 USA.;Zoetis, VMRD Global Biol Res, Kalamazoo, MI 49007 USA.4 aut
700	1	a Cheng, Hans H.u ARS, Avian Dis & Oncol Lab, USDA, E Lansing, MI 48823 USA.4 aut
700	1	a Knight, Christopher J.u Stanford Univ, Hopkins Marine Stn, Pacific Grove, CA 93950 USA.4 aut
700	1	a Burnham, Theresa L. U.u Univ Calif Davis, Dept Wildlife Fish & Conservat Biol, Davis, CA 95616 USA.;San Diego State Univ, Coastal & Marine Inst, San Diego, CA 92106 USA.;San Diego State Univ, Dept Biol, San Diego, CA 92106 USA.4 aut
700	1	a Hovel, Kevin A.u San Diego State Univ, Coastal & Marine Inst, San Diego, CA 92106 USA.;San Diego State Univ, Dept Biol, San Diego, CA 92106 USA.4 aut
700	1	a Beel, Andrew J.u Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.4 aut
700	1	a Mattei, Pierre-Jeanu Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.4 aut
700	1	a Kornberg, Roger D.u Stanford Univ, Dept Struct Biol, Sch Med, Stanford, CA 94305 USA.4 aut
700	1	a Warren, Wesley C.u Univ Missouri, Dept Anim Sci, Columbia, MO 65211 USA.4 aut
700	1	a Cary, Gregoryu Jackson Lab, Bar Harbor, ME 04609 USA.4 aut
700	1	a Gomez-Skarmeta, Jose Luisu Univ Pablo de Olavide, Ctr Andaluz Biol Desarrollo, CSIC, Seville 41013, Spain.4 aut
700	1	a Hinman, Veronicau Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA.4 aut
700	1	a Lindblad-Toh, Kerstinu Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut0 (Swepub:uu)kerli865
700	1	a Di Palma, Federicau Univ East Anglia, Dept Biol Sci, Norwich NR4 7TJ, Norfolk, England.4 aut
700	1	a Maeshima, Kazuhirou Natl Inst Genet, Genome Dynam Lab, Mishima, Shizuoka 4118540, Japan.;Sokendai Grad Univ Adv Studies, Dept Genet, Mishima, Shizuoka 4118540, Japan.4 aut
700	1	a Multani, Asha S.u Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA.4 aut
700	1	a Pathak, Sen4 aut
700	1	a Nel-Themaat, Lieslu Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA.;Univ Colorado Adv Reprod Med, Denver, CO 80238 USA.4 aut
700	1	a Behringer, Richard R.u Univ Texas MD Anderson Canc Ctr, Dept Genet, Houston, TX 77030 USA.4 aut
700	1	a Kaur, Parwinderu Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia.4 aut
700	1	a Medema, Rene H.u Netherlands Canc Inst, Oncode Inst, Div Cell Biol, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a van Steensel, Basu Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a de Wit, Elzou Netherlands Canc Inst, Oncode Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
700	1	a Onuchic, Jose N.u Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;Rice Univ, Dept Phys & Astron, Houston, TX 77005 USA.;Rice Univ, Dept Chem, Houston, TX 77005 USA.;Rice Univ, Dept Biosci, Houston, TX 77005 USA.4 aut
700	1	a Di Pierro, Micheleu Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;Northeastern Univ, Dept Phys, Boston, MA 02115 USA.4 aut
700	1	a Aiden, Erez Liebermanu Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.;ShanghaiTech, Shanghai Inst Adv Immunochem Studies, Pudong 201210, Peoples R China.;Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.4 aut
700	1	a Rowland, Benjamin D.u Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.4 aut
710	2	a Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands.b Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA.;Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.;Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA.4 org
773	0	t Scienced : American Association for the Advancement of Science (AAAS)g 372:6545, s. 984-989q 372:6545<984-989x 0036-8075x 1095-9203
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-449355
856	4 8	u https://doi.org/10.1126/science.abe2218

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Av författaren/redakt...: Hoencamp, Claire; Dudchenko, Olga; Elbatsh, Ahmed M ...; Brahmachari, Sum ...; Raaijmakers, Jon ...; van Schaik, Tom; visa fler...; Cacciatore, Ange ...; Contessoto, Vini ...; van Heesbeen, Ro ...; van den Broek, B ...; Mhaskar, Aditya ...; Teunissen, Hans; St Hilaire, Bria ...; Weisz, David; Omer, Arina D.; Pham, Melanie; Colaric, Zane; Yang, Zhenzhen; Rao, Suhas S. P.; Mitra, Namita; Lui, Christopher; Yao, Weijie; Khan, Ruqayya; Moroz, Leonid L.; Kohn, Andrea; St Leger, Judy; Mena, Alexandria; Holcroft, Karen; Gambetta, Maria ...; Lim, Fabian; Farley, Emma; Stein, Nils; Haddad, Alexande ...; Chauss, Daniel; Mutlu, Ayse Sena; Wang, Meng C.; Young, Neil D.; Hildebrandt, Evi ...; Cheng, Hans H.; Knight, Christop ...; Burnham, Theresa ...; Hovel, Kevin A.; Beel, Andrew J.; Mattei, Pierre-J ...; Kornberg, Roger ...; Warren, Wesley C ...; Cary, Gregory; Gomez-Skarmeta, ...; Hinman, Veronica; Lindblad-Toh, Ke ...; Di Palma, Federi ...; Maeshima, Kazuhi ...; Multani, Asha S.; Pathak, Sen; Nel-Themaat, Lie ...; Behringer, Richa ...; Kaur, Parwinder; Medema, Rene H.; van Steensel, Ba ...; de Wit, Elzo; Onuchic, Jose N.; Di Pierro, Miche ...; Aiden, Erez Lieb ...; Rowland, Benjami ...; visa färre...

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