AMNE:(NATURVETENSKAP) AMNE:(Biologi) AMNE:(Utvecklingsbiologi)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04181naa a2200517 4500 | |
| 001 | oai:DiVA.org:uu-153282 | |
| 003 | SwePub | |
| 008 | 110510s2011 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-104451 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1532822 URI |
| 024 | 7 | a https://doi.org/10.1016/j.aquatox.2011.02.0032 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1044512 URI |
| 040 | a (SwePub)uud (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kvarnryd, Moau Uppsala universitet,Ekotoxikologi4 aut |
| 245 | 1 0 | a Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs |
| 264 | 1 | b Elsevier BV,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Levonorgestrel (LNG) is a commonly used pharmaceutical progestin found in the environment. Information on the long-term toxicity of progestins following early life exposure is scant. We investigated the effects of developmental LNG exposure on sex differentiation, reproductive organ development and fertility in the model frog Xenopus tropicalis. Tadpoles were exposed to 0, 0.06 or 0.5 nM LNG via the water from hatching until metamorphosis. At metamorphosis effects on gonadal differentiation were evaluated using a subsample of frogs. Remaining animals were held unexposed for nine months, at which time reproductive organ structure, function and fertility were determined. LNG exposure severely impaired oviduct and ovary development and fertility. All adult females in the 0.5 nM group (n = 10) completely lacked oviducts. They also displayed a significantly larger fraction of immature oocytes, arrested in meiotic prophase, than control females. Upon mating with unexposed males, only one of 11 LNG-exposed females laid eggs, whereas all control females did. No effects on testicular development, sperm count or male fertility were observed. At metamorphosis, no effects on sex ratio or gonadal histology were evident. The effects on ovarian and oviductal development were detected at adult age but not at metamorphosis, emphasising the importance of investigating the long-term consequences of developmental exposure. This is the first developmental reproductive toxicity study of a progestin in an aquatic vertebrate. Considering that several progestins are present in contaminated surface waters, further investigation into the sensitivity of frogs to progestins is warranted to understand the risk such compounds may pose to wild frog populations. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Utvecklingsbiologi0 (SwePub)106142 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Developmental Biology0 (SwePub)106142 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
| 653 | a Endocrine disruption | |
| 653 | a Developmental reproductive toxicity | |
| 653 | a Levonorgestrel | |
| 653 | a Oogenesis | |
| 653 | a Oviduct | |
| 653 | a Sex differentiation | |
| 653 | a Biology | |
| 653 | a Biologi | |
| 653 | a Ecotoxicology | |
| 653 | a Ekotoxikologi | |
| 700 | 1 | a Grabic, Romanu Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)rogr0011 |
| 700 | 1 | a Brandt, Ingvaru Uppsala universitet,Ekotoxikologi4 aut0 (Swepub:uu)ingvbran |
| 700 | 1 | a Berg, Ceciliau Uppsala universitet,Ekotoxikologi4 aut0 (Swepub:uu)ceciberg |
| 710 | 2 | a Uppsala universitetb Ekotoxikologi4 org |
| 773 | 0 | t Aquatic Toxicologyd : Elsevier BVg 103:1-2, s. 18-24q 103:1-2<18-24x 0166-445Xx 1879-1514 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153282 |
| 856 | 4 8 | u https://doi.org/10.1016/j.aquatox.2011.02.003 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-104451 |
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