Sökning: L773:0887 4476 OR L773:1098 2396 >
Effect on [11C]DASB...
Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration : positron emission tomography studies in monkeys and rats
-
- Lundquist, Pinelopi (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,PKPD
-
- Roman, Magnus (författare)
- Uppsala Imanet
-
- Syvänen, Stina (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,PKPD
-
visa fler...
-
- Hartvig, Per (författare)
- Hospital Pharmacy, University Hospital
-
- Blomquist, Gunnar (författare)
- Uppsala Imanet
-
- Hammarlund-Udenaes, Margareta (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,PKPD
-
- Långström, Bengt (författare)
- Uppsala Imanet
-
visa färre...
-
(creator_code:org_t)
- 2007
- 2007
- Engelska.
-
Ingår i: Synapse. - : Wiley. - 0887-4476 .- 1098-2396. ; 61:6, s. 440-449
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Several research groups have demonstrated that under specific conditions, in vivo neuroreceptor binding techniques can be used to measure acute changes in the concentrations of endogenous transmitters in the vicinity of neuroreceptors. The aim of this study was to investigate whether [11C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile ([11C]DASB) binding to the plasma membrane serotonin transporter (SERT) in the rhesus monkey and rat brain decreased after a pharmacologically-induced increase in the interstitial serotonin (5HT) concentration. Three rhesus monkeys were given repeated single boluses of [11C]DASB in sequential positron emission tomography (PET) experiments. Rats were given the tracer as a bolus dose plus a constant infusion. In vivo binding in both models was studied before and after presumably having increased interstitial 5HT concentrations using tranylcypromine (TCP), which inhibits the enzyme (monoamine oxidase, MAO), that degrades 5HT. The rat brain tissue was analyzed using high-performance liquid chromatography (HPLC) to determine the proportion of the PET signal comprising unchanged [11C]DASB. The binding of [11C]DASB in the thalamus decreased in both rhesus monkeys and rats after TCP administration. The possibility of using [11C]DASB as a tool for monitoring changes in endogenous serotonin concentrations merits further investigation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Endogenous serotonin
- positron emission tomography (PET)
- in vivo binding
- [11C]DASB
- brain
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Synapse
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas