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IGF-I has a direct ...
IGF-I has a direct proliferative effect in adult hippocampal progenitor cells.
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- Åberg, Maria A I, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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- Åberg, N David, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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Palmer, Theo D (author)
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- Alborn, Ann-Marie, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience
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- Carlsson-Skwirut, Christine (author)
- Karolinska Institutet
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- Bang, Peter (author)
- Karolinska Institutet
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- Rosengren, Lars, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för kliniska nervsjukdomar,Institute of Clinical Neurosciences, Section of Neurological Diseases
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Olsson, Torsten (author)
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Gage, Fred H (author)
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- Eriksson, Peter S, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Molecular and cellular neurosciences. - 1044-7431. ; 24:1, s. 23-40
- Related links:
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https://gup.ub.gu.se...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The aim of the present study was to investigate the potential direct effects of insulin-like growth factor-I (IGF-I) on adult rat hippocampal stem/progenitor cells (AHPs). IGF-I-treated cultures showed a dose-dependent increase in thymidine incorporation, total number of cells, and number of cells entering the mitosis phase. Pretreatment with fibroblast growth factor-2 (FGF-2) increased the IGF-I receptor (IGF-IR) expression, and both FGF-2 and IGF-I were required for maximal proliferation. Time-lapse recordings showed that IGF-I at 100 ng/ml decreased differentiation and increased proliferation of single AHPs. Specific inhibition of mitogen-activated protein kinase kinase (MAPKK), phosphatidylinositol 3-kinase (PI3-K), or the downstream effector of the PI3-K pathway, serine/threonine p70 S6 kinase (p70(S6K)), showed that both the MAPK and the PI3-K pathways participate in IGF-I-induced proliferation but that the MAPK activation is obligatory. These results were confirmed with dominant-negative constructs for these pathways. Stimulation of differentiation was found at a low dose (1 ng/ml) of IGF-I, clonal analysis indicating an instructive component of IGF-I signaling.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- 1-Phosphatidylinositol 3-Kinase
- drug effects
- metabolism
- Animals
- Cell Differentiation
- drug effects
- physiology
- Cell Division
- drug effects
- physiology
- Cell Lineage
- drug effects
- physiology
- Cells
- Cultured
- Dose-Response Relationship
- Drug
- Fibroblast Growth Factor 2
- metabolism
- pharmacology
- Hippocampus
- cytology
- drug effects
- growth & development
- Insulin-Like Growth Factor Binding Proteins
- drug effects
- metabolism
- Insulin-Like Growth Factor I
- metabolism
- pharmacology
- MAP Kinase Signaling System
- drug effects
- physiology
- Rats
- Receptor
- IGF Type 1
- drug effects
- metabolism
- Ribosomal Protein S6 Kinases
- 70-kDa
- drug effects
- metabolism
- Signal Transduction
- drug effects
- physiology
- Stem Cells
- cytology
- drug effects
- metabolism
- Thymidine
- metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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Åberg, Maria A I ...
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Åberg, N David, ...
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Palmer, Theo D
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Alborn, Ann-Mari ...
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Carlsson-Skwirut ...
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Bang, Peter
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Rosengren, Lars, ...
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Olsson, Torsten
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Gage, Fred H
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Eriksson, Peter ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Molecular and ce ...
- By the university
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University of Gothenburg
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Karolinska Institutet