Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source

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Fältnamn	Indikatorer	Metadata
000		03426naa a2200553 4500
001		oai:lup.lub.lu.se:23bafbbe-c8f3-4372-bcfa-d22bee21125c
003		SwePub
008		160401s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/32627222 URI
024	7	a https://doi.org/10.1073/pnas.12066841092 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Schleede, Simone4 aut
245	1 0	a Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source
264		c 2012-10-16
264	1	b Proceedings of the National Academy of Sciences,c 2012
520		a In early stages of various pulmonary diseases, such as emphysema and fibrosis, the change in X-ray attenuation is not detectable with absorption-based radiography. To monitor the morphological changes that the alveoli network undergoes in the progression of these diseases, we propose using the dark-field signal, which is related to small-angle scattering in the sample. Combined with the absorption-based image, the dark-field signal enables better discrimination between healthy and emphysematous lung tissue in a mouse model. All measurements have been performed at 36 keV using a monochromatic laser-driven miniature synchrotron X-ray source (Compact Light Source). In this paper we present grating-based dark-field images of emphysematous vs. healthy lung tissue, where the strong dependence of the dark-field signal on mean alveolar size leads to improved diagnosis of emphysema in lung radiographs.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653		a grating interferometer
653		a pulmonary emphysema
653		a X-ray imaging
700	1	a Meinel, Felix G.4 aut
700	1	a Bech, Martinu Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mbh
700	1	a Herzen, Julia4 aut
700	1	a Achterhold, Klaus4 aut
700	1	a Potdevin, Guillaume4 aut
700	1	a Malecki, Andreas4 aut
700	1	a Adam-Neumair, Silvia4 aut
700	1	a Thieme, Sven F.4 aut
700	1	a Bamberg, Fabian4 aut
700	1	a Nikolaou, Konstantin4 aut
700	1	a Bohla, Alexander4 aut
700	1	a Yildirim, Ali Oe.4 aut
700	1	a Loewen, Roderick4 aut
700	1	a Gifford, Martin4 aut
700	1	a Ruth, Ronald4 aut
700	1	a Eickelberg, Oliver4 aut
700	1	a Reiser, Maximilian4 aut
700	1	a Pfeiffer, Franz4 aut
710	2	a Medicinsk strålningsfysik, Lundb Sektion V4 org
773	0	t Proceedings of the National Academy of Sciencesd : Proceedings of the National Academy of Sciencesg 109:44, s. 17880-17885q 109:44<17880-17885x 1091-6490x 0027-8424
856	4	u http://dx.doi.org/10.1073/pnas.1206684109y FULLTEXT
856	4	u https://www.pnas.org/content/pnas/109/44/17880.full.pdf
856	4 8	u https://lup.lub.lu.se/record/3262722
856	4 8	u https://doi.org/10.1073/pnas.1206684109

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