Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries

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Fältnamn	Indikatorer	Metadata
000		05083naa a2200829 4500
001		oai:gup.ub.gu.se/295832
003		SwePub
008		240910s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2958322 URI
024	7	a https://doi.org/10.1093/ajcn/nqz3482 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Dehghan, M.4 aut
245	1 0	a Association of egg intake with blood lipids, cardiovascular disease, and mortality in 177,000 people in 50 countries
264	1	b Elsevier BV,c 2020
520		a Background: Eggs are a rich source of essential nutrients, but they are also a source of dietary cholesterol. Therefore, some guidelines recommend limiting egg consumption. However, there is contradictory evidence on the impact of eggs on diseases, largely based on studies conducted in high-income countries. Objectives: Our aim was to assess the association of egg consumption with blood lipids, cardiovascular disease (CVD), and mortality in large global studies involving populations from low-, middle-, and high-income countries. Methods: We studied 146,011 individuals from 21 countries in the Prospective Urban Rural Epidemiology (PURE) study. Egg consumption was recorded using country-specific validated FFQs. We also studied 31,544 patients with vascular disease in 2 multinational prospective studies: ONTARGET (Ongoing Telmisartan Alone and in Combination with Ramipril Global End Point Trial) and TRANSCEND (Telmisartan Randomized Assessment Study in ACEI Intolerant Subjects with Cardiovascular Disease). We calculated HRs using multivariable Cox frailty models with random intercepts to account for clustering by study center separately within each study. Results: In the PURE study, we recorded 14,700 composite events (8932 deaths and 8477 CVD events). In the PURE study, after excluding those with history of CVD, higher intake of egg (>= 7 egg/wk compared with <1 egg/wk intake) was not significantly associated with blood lipids, composite outcome (HR: 0.96; 95% CI: 0.89, 1.04; P-trend = 0.74), total mortality (HR: 1.04; 95% CI: 0.94, 1.15; P-trend = 0.38), or major CVD (HR: 0.92; 95% CI: 0.83, 1.01; P-trend = 0.20). Similar results were observed in ONTARGET/TRANSCEND studies for composite outcome (HR 0.97; 95% CI: 0.76, 1.25; P-trend = 0.09), total mortality (HR: 0.88; 95% CI: 0.62, 1.24; P-trend = 0.55), and major CVD(HR: 0.97; 95% CI: 0.73, 1.29; P-trend = 0.12). Conclusions: In 3 large international prospective studies including similar to 177,000 individuals, 12,701 deaths, and 13,658 CVD events from 50 countries in 6 continents, we did not find significant associations between egg intake and blood lipids, mortality, or major CVD events.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653		a egg intake
653		a dietary cholesterol
653		a blood lipids
653		a mortality
653		a cardiovascular
653		a disease
653		a dietary-cholesterol
653		a consumption
653		a risk
653		a phospholipids
653		a pressure
653		a Nutrition & Dietetics
700	1	a Mente, A.4 aut
700	1	a Rangarajan, S.4 aut
700	1	a Mohan, V.4 aut
700	1	a Lear, S.4 aut
700	1	a Swaminathan, S.4 aut
700	1	a Wielgosz, A.4 aut
700	1	a Seron, P.4 aut
700	1	a Avezum, A.4 aut
700	1	a Lopez-Jaramillo, P.4 aut
700	1	a Turbide, G.4 aut
700	1	a Chifamba, J.4 aut
700	1	a AlHabib, K. F.4 aut
700	1	a Mohammadifard, N.4 aut
700	1	a Szuba, A.4 aut
700	1	a Khatib, R.4 aut
700	1	a Altuntas, Y.4 aut
700	1	a Liu, X. Y.4 aut
700	1	a Iqbal, R.4 aut
700	1	a Rosengren, Annika,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xrosan
700	1	a Yusuf, R.4 aut
700	1	a Smuts, M.4 aut
700	1	a Yusufali, A.4 aut
700	1	a Li, N.4 aut
700	1	a Diaz, R.4 aut
700	1	a Yusoff, K.4 aut
700	1	a Kaur, M.4 aut
700	1	a Soman, B.4 aut
700	1	a Ismail, N.4 aut
700	1	a Gupta, R.4 aut
700	1	a Dans, A.4 aut
700	1	a Sheridan, P.4 aut
700	1	a Teo, K.4 aut
700	1	a Anand, S. S.4 aut
700	1	a Yusuf, S.4 aut
710	2	a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
773	0	t American Journal of Clinical Nutritiond : Elsevier BVg 111:4, s. 795-803q 111:4<795-803x 0002-9165
856	4	u https://academic.oup.com/ajcn/article-pdf/111/4/795/32993903/nqz348.pdf
856	4 8	u https://gup.ub.gu.se/publication/295832
856	4 8	u https://doi.org/10.1093/ajcn/nqz348

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