SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Biggs J.)
 

Sökning: WFRF:(Biggs J.) > Differential White ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004520naa a2200673 4500
001oai:DiVA.org:uu-133582
003SwePub
008101111s2010 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:121487280
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1335822 URI
0247 a https://doi.org/10.1371/journal.pone.00134052 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1214872802 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gkrania-Klotsas, Effrossyni4 aut
2451 0a Differential White Blood Cell Count and Type 2 Diabetes :b Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Studies
264 c 2010-10-18
264 1b Public Library of Science (PLoS),c 2010
338 a print2 rdacarrier
520 a OBJECTIVE: Biological evidence suggests that inflammation might induce type 2 diabetes (T2D), and epidemiological studies have shown an association between higher white blood cell count (WBC) and T2D. However, the association has not been systematically investigated. RESEARCH DESIGN AND METHODS: Studies were identified through computer-based and manual searches. Previously unreported studies were sought through correspondence. 20 studies were identified (8,647 T2D cases and 85,040 non-cases). Estimates of the association of WBC with T2D were combined using random effects meta-analysis; sources of heterogeneity as well as presence of publication bias were explored. RESULTS: The combined relative risk (RR) comparing the top to bottom tertile of the WBC count was 1.61 (95% CI: 1.45; 1.79, p = 1.5*10(-18)). Substantial heterogeneity was present (I(2) = 83%). For granulocytes the RR was 1.38 (95% CI: 1.17; 1.64, p = 1.5*10(-4)), for lymphocytes 1.26 (95% CI: 1.02; 1.56, p = 0.029), and for monocytes 0.93 (95% CI: 0.68; 1.28, p = 0.67) comparing top to bottom tertile. In cross-sectional studies, RR was 1.74 (95% CI: 1.49; 2.02, p = 7.7*10(-13)), while in cohort studies it was 1.48 (95% CI: 1.22; 1.79, p = 7.7*10(-5)). We assessed the impact of confounding in EPIC-Norfolk study and found that the age and sex adjusted HR of 2.19 (95% CI: 1.74; 2.75) was attenuated to 1.82 (95% CI: 1.45; 2.29) after further accounting for smoking, T2D family history, physical activity, education, BMI and waist circumference. CONCLUSIONS: A raised WBC is associated with higher risk of T2D. The presence of publication bias and failure to control for all potential confounders in all studies means the observed association is likely an overestimate.
653 a MEDICINE
653 a MEDICIN
7001 a Ye, Zheng4 aut
7001 a Cooper, Andrew J.4 aut
7001 a Sharp, Stephen J.4 aut
7001 a Luben, Robert4 aut
7001 a Biggs, Mary L.4 aut
7001 a Chen, Liang-Kung4 aut
7001 a Gokulakrishnan, Kuppan4 aut
7001 a Hanefeld, Markolf4 aut
7001 a Ingelsson, Eriku Karolinska Institutet4 aut
7001 a Lai, Wen-An4 aut
7001 a Lin, Shih-Yi4 aut
7001 a Lind, Larsu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)laeli995
7001 a Lohsoonthorn, Vitool4 aut
7001 a Mohan, Viswanathan4 aut
7001 a Muscari, Antonio4 aut
7001 a Nilsson, Göranu Uppsala universitet,Centrum för klinisk forskning, Västerås4 aut0 (Swepub:uu)gorni318
7001 a Ohrvik, Johnu Karolinska Institutet4 aut
7001 a Qiang, Jiang Chao4 aut
7001 a Jenny, Nancy Swords4 aut
7001 a Tamakoshi, Koji4 aut
7001 a Temelkova-Kurktschiev, Theodora4 aut
7001 a Wang, Ya-Yu4 aut
7001 a Yajnik, Chittaranjan Sakerlal4 aut
7001 a Zoli, Marco4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Forouhi, Nita G.4 aut
7001 a Wareham, Nicholas J.4 aut
7001 a Langenberg, Claudia4 aut
7102 a Karolinska Institutetb Institutionen för medicinska vetenskaper4 org
7730 t PloS oned : Public Library of Science (PLoS)g 5:10, s. e13405-q 5:10<e13405-x 1932-6203
8564 u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0013405&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-133582
8564 8u https://doi.org/10.1371/journal.pone.0013405
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:121487280

Hitta via bibliotek

  • PloS one (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy