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A nutritional suppl...
A nutritional supplement containing zinc during preconception and pregnancy increases human milk zinc concentrations
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- Han, Soo Min (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.
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- Devaraj, Surabhi (författare)
- Nestle Res, Soc Prod Nestle SA, Singapore, Singapore.
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- Derraik, José G. B. (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Univ Auckland, Liggins Inst, Auckland, New Zealand.;Chiang Mai Univ, Res Inst Hlth Sci, Environm Occupat Hlth Sci & Noncommunicable Dis Re, Chiang Mai, Thailand.;Univ Auckland, Fac Med & Hlth Sci, Sch Med, Dept Paediat Child & Youth Hlth, Auckland, New Zealand.
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- Vickers, Mark H. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.
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- Huang, Fang (författare)
- Nestle Res, Soc Prod Nestle SA, Beijing, Peoples R China.
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- Dubascoux, Stephane (författare)
- Nestle Res, Soc Prod Nestle SA, Lausanne, Switzerland.
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- Godfrey, Keith M. (författare)
- Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, England.;NHS Fdn Trust, Univ Hosp Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.
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- Chan, Shiao-Yng (författare)
- Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.;Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore.
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- Pang, Wei Wei (författare)
- Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.
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- Thakkar, Sagar K. (författare)
- Nestle Res, Soc Prod Nestle SA, Singapore, Singapore.
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- Cutfield, Wayne S. (författare)
- Univ Auckland, Liggins Inst, Auckland, New Zealand.
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Grp, NiPPeR Study (författare)
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Univ Auckland, Liggins Inst, Auckland, New Zealand Nestle Res, Soc Prod Nestle SA, Singapore, Singapore. (creator_code:org_t)
- 2023-01-10
- 2023
- Engelska.
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Ingår i: Frontiers in Nutrition. - : Frontiers Media S.A.. - 2296-861X. ; 9
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- Introduction: During pregnancy and lactation minerals such as zinc are required to support maternal and infant health. Zinc is involved in various cellular processes, with requirements increasing in pregnancy and lactation. In the setting of a randomized trial, we investigated the effects on human milk (HM) zinc concentrations of a micronutrient-containing supplement including zinc in the intervention (but not control) group, started preconception and taken throughout pregnancy until birth. Additionally, we characterized longitudinal changes in HM concentrations of zinc and other minerals (calcium, copper, iodine, iron, magnesium, manganese, phosphorus, potassium, selenium, and sodium). Methods: HM samples were collected across 7 time points from 1 week to 12 months from lactating mothers from Singapore (n = 158) and New Zealand (n = 180). HM minerals were quantified using sector field inductively coupled plasma mass spectrometry. Potential intervention effects on HM mineral concentrations were assessed using linear mixed models with a repeated measures design and time-weighted area-under-the-curve analyses. Results: Over the first 3 months of lactation, HM zinc concentrations were 11% higher in the intervention group compared to the control group (p = 0.021). Higher HM zinc concentrations were most evident at 6 weeks of lactation. The intervention had no effect on HM concentrations of other minerals, which were not differently supplemented to the control and intervention groups. Temporal changes in HM minerals over 12 months of lactation were studied in the New Zealand mothers; HM zinc and copper concentrations progressively decreased throughout 12 months, while iron, potassium, sodium, and phosphorus decreased until 6 months then plateaued. HM calcium and magnesium initially increased in early lactation and iodine remained relatively constant throughout 12 months. HM manganese and selenium fell over the initial months of lactation, with a nadir at 6 months, and increased thereafter. The contrasting patterns of changes in HM mineral concentrations during lactation may reflect different absorption needs and roles at different stages of infancy. Discussion: Overall, this study indicates that HM zinc concentrations are influenced by maternal supplementation during preconception and pregnancy. Further studies are required to understand the associations between HM zinc and other minerals and both short- and long-term offspring outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- human milk
- minerals
- pregnancy
- supplement
- zinc
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Han, Soo Min
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Devaraj, Surabhi
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Derraik, José G. ...
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Vickers, Mark H.
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Huang, Fang
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Dubascoux, Steph ...
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Godfrey, Keith M ...
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Chan, Shiao-Yng
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Pang, Wei Wei
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Thakkar, Sagar K ...
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Cutfield, Wayne ...
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Grp, NiPPeR Stud ...
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