WFRF:(Henry S M)
Sökning: WFRF:(Henry S M) > (2005-2009) > Ethanol reverses th...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03799naa a2200793 4500 | |
| 001 | oai:gup.ub.gu.se/82236 | |
| 003 | SwePub | |
| 008 | 240528s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/822362 URI |
| 024 | 7 | a https://doi.org/10.1111/j.1460-9568.2007.05606.x2 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Yin, Henry H4 aut |
| 245 | 1 0 | a Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. |
| 264 | c 2007-06-06 | |
| 264 | 1 | b Wiley,c 2007 |
| 520 | a The striatum is a critical structure for the control of voluntary behaviour, and striatal synaptic plasticity has been implicated in instrumental learning. As ethanol consumption can cause impairments in cognition, learning, and action selection, it is important to understand the effects of this drug on striatal function. In this study we examined the effects of ethanol on long-term synaptic plasticity in the dorsomedial striatum (DMS), a striatal subregion that plays a central role in the acquisition and selection of goal-directed actions. Ethanol was found to impair N-methyl-d-aspartic acid receptor (NMDAR)-dependent long-term potentiation (LTP) dose-dependently in the DMS, and to promote long-term depression (LTD) at the highest concentration (50 mm) used. These results suggest that ethanol, at a concentration usually associated with mild intoxication, could significantly change experience-dependent modification of corticostriatal circuits underlying the learning of goal-directed instrumental actions. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
| 653 | a Animals | |
| 653 | a Animals | |
| 653 | a Newborn | |
| 653 | a Central Nervous System Depressants | |
| 653 | a pharmacology | |
| 653 | a Corpus Striatum | |
| 653 | a cytology | |
| 653 | a Dopamine Antagonists | |
| 653 | a pharmacology | |
| 653 | a Dose-Response Relationship | |
| 653 | a Drug | |
| 653 | a Dose-Response Relationship | |
| 653 | a Radiation | |
| 653 | a Electric Stimulation | |
| 653 | a Ethanol | |
| 653 | a pharmacology | |
| 653 | a Evoked Potentials | |
| 653 | a drug effects | |
| 653 | a physiology | |
| 653 | a radiation effects | |
| 653 | a Neuronal Plasticity | |
| 653 | a drug effects | |
| 653 | a Neurons | |
| 653 | a drug effects | |
| 653 | a physiology | |
| 653 | a Patch-Clamp Techniques | |
| 653 | a methods | |
| 653 | a Piperidines | |
| 653 | a pharmacology | |
| 653 | a Pyrazoles | |
| 653 | a pharmacology | |
| 653 | a Rats | |
| 653 | a Rats | |
| 653 | a Sprague-Dawley | |
| 653 | a Sulpiride | |
| 653 | a pharmacology | |
| 653 | a Synaptic Transmission | |
| 653 | a drug effects | |
| 653 | a physiology | |
| 653 | a Time Factors | |
| 700 | 1 | a Park, Brian S4 aut |
| 700 | 1 | a Adermark, Louise,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xadelo |
| 700 | 1 | a Lovinger, David M4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t The European journal of neuroscienced : Wileyg 25:11, s. 3226-32q 25:11<3226-32x 0953-816Xx 1460-9568 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/82236 |
| 856 | 4 8 | u https://doi.org/10.1111/j.1460-9568.2007.05606.x |
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