Genome-wide association study of glioma and meta-analysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Howard Mark) > Genome-wide associa...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		11676naa a2201225 4500
001		oai:DiVA.org:uu-422339
003		SwePub
008		201013s2012 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-60172
009		oai:prod.swepub.kib.ki.se:125557180
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4223392 URI
024	7	a https://doi.org/10.1007/s00439-012-1212-02 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601722 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1255571802 URI
040		a (SwePub)uud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Rajaraman, Preethau NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
245	1 0	a Genome-wide association study of glioma and meta-analysis
264		c 2012-08-11
264	1	b SPRINGER,c 2012
338		a print2 rdacarrier
520		a Gliomas account for approximately 80 % of all primary malignant brain tumors and, despite improvements in clinical care over the last 20 years, remain among the most lethal tumors, underscoring the need for gaining new insights that could translate into clinical advances. Recent genome-wide association studies (GWAS) have identified seven new susceptibility regions. We conducted a new independent GWAS of glioma using 1,856 cases and 4,955 controls (from 14 cohort studies, 3 case-control studies, and 1 population-based case-only study) and found evidence of strong replication for three of the seven previously reported associations at 20q13.33 (RTEL), 5p15.33 (TERT), and 9p21.3 (CDKN2BAS), and consistent association signals for the remaining four at 7p11.2 (EGFR both loci), 8q24.21 (CCDC26) and 11q23.3 (PHLDB1). The direction and magnitude of the signal were consistent for samples from cohort and case-control studies, but the strength of the association was more pronounced for loci rs6010620 (20q,13.33; RTEL) and rs2736100 (5p15.33, TERT) in cohort studies despite the smaller number of cases in this group, likely due to relatively more higher grade tumors being captured in the cohort studies. We further examined the 85 most promising single nucleotide polymorphism (SNP) markers identified in our study in three replication sets (5,015 cases and 11,601 controls), but no new markers reached genome-wide significance. Our findings suggest that larger studies focusing on novel approaches as well as specific tumor subtypes or subgroups will be required to identify additional common susceptibility loci for glioma risk.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Melin, Beatrice Su Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden.,Univ Texas MD Anderson Canc Ctr, Dept Biostat, Orlando, TX USA.4 aut0 (Swepub:umu)bema0010
700	1	a Wang, Zhaomingu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut
700	1	a McKean-Cowdin, Robertau Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.4 aut
700	1	a Michaud, Dominique S.u Brown Univ, Div Biol & Med, Dept Epidemiol, Providence, RI 02912 USA.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England.4 aut
700	1	a Wang, Sophia S.u City Hope Natl Med Ctr, Div Canc Etiol, Dept Populat Sci, Duarte, CA USA.;City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USA.4 aut
700	1	a Bondy, Melissau Baylor Coll Med, Houston, TX 77030 USA.4 aut
700	1	a Houlston, Richardu Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.4 aut
700	1	a Jenkins, Robert B.u Mayo Clin, Rochester, MN USA.4 aut
700	1	a Wrensch, Margaretu Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut
700	1	a Yeager, Meredithu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut
700	1	a Ahlbom, Andersu Karolinska Institutet4 aut
700	1	a Albanes, Demetriusu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Andersson, Ulrikau Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden.4 aut0 (Swepub:umu)ulan0002
700	1	a Freeman, Laura E. Beaneu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Buring, Julie E.u Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.4 aut
700	1	a Butler, Mary Annu Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA.4 aut
700	1	a Braganza, Melissau NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Carreon, Taniau Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA.4 aut
700	1	a Feychting, Mariau Karolinska Institutet4 aut
700	1	a Fleming, Sarah J.u Univ Leeds, Div Biostat, Leeds, W Yorkshire, England.4 aut
700	1	a Gapstur, Susan M.u Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.4 aut
700	1	a Gaziano, J. Michaelu Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.;VA Boston Healthcare Syst, Massachusetts Vet Epidemiol, Res & Informat Ctr, Geriatr Res Educ & Clin Ctr, Boston, MA USA.4 aut
700	1	a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.4 aut
700	1	a Hallmans, Göranu Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med Nutr Res, Umea, Sweden.4 aut0 (Swepub:umu)goha0001
700	1	a Henriksson, Rogeru Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Umea, Sweden.4 aut0 (Swepub:umu)rohe0003
700	1	a Hoffman-Bolton, Judithu Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.4 aut
700	1	a Inskip, Peter D.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Johansen, Christofferu Danish Canc Soc, Res Ctr, Unit Survivorship, Copenhagen, Denmark.4 aut
700	1	a Kitahara, Cari M.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Lathrop, Marku IG CEA, Ctr Natl Genotypage, Evry, France.;Fdn Jean Dauset CEPH, Paris, France.4 aut
700	1	a Liu, Chenweiu NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut
700	1	a Le Marchand, Loicu Univ Hawaii, Canc Res Ctr, Honolulu, HI 96822 USA.4 aut
700	1	a Linet, Martha S.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Lonn, Stefanu Karolinska Institutet4 aut
700	1	a Peters, Ulrikeu Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
700	1	a Purdue, Mark P.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Rothman, Nathanielu NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Ruder, Avima M.u Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Cincinnati, OH USA.4 aut
700	1	a Sanson, Marcu APHP, GH Pitie Salpetriere, Serv Neurol Mazarin, Paris, France.;CRICM, UMR INSERM UPMC 975, Paris, France.4 aut
700	1	a Sesso, Howard D.u Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Sch Med, Boston, MA USA.4 aut
700	1	a Severi, Gianlucau Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.4 aut
700	1	a Shu, Xiao-Ouu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut
700	1	a Simon, Matthiasu Neurochirurg Univklin, Bonn, Germany.4 aut
700	1	a Stampfer, Meiru Harvard Univ, Sch Med, Channing Lab, Brigham & Womens Hosp, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.4 aut
700	1	a Stevens, Victoria L.u Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.4 aut
700	1	a Visvanathan, Kalau Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.;Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.4 aut
700	1	a White, Emilyu Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.4 aut
700	1	a Wolk, Alicjau Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-10401 Stockholm, Sweden.4 aut
700	1	a Zeleniuch-Jacquotte, Anneu NYU, Sch Med, Div Epidemiol, Dept Environm Med, New York, NY USA.4 aut
700	1	a Zheng, Weiu Vanderbilt Univ, Med Ctr, Nashville, TN USA.4 aut
700	1	a Decker, Paulu Mayo Clin, Rochester, MN USA.4 aut
700	1	a Enciso-Mora, Victoru Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.4 aut
700	1	a Fridley, Brookeu Mayo Clin, Rochester, MN USA.4 aut
700	1	a Gao, Yu-Tangu Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Dept Epidemiol,Renji Hosp, Shanghai 200030, Peoples R China.4 aut
700	1	a Kosel, Matthewu Mayo Clin, Rochester, MN USA.4 aut
700	1	a Lachance, Daniel H.u Mayo Clin, Rochester, MN USA.4 aut
700	1	a Lau, Chingu Baylor Coll Med, Houston, TX 77030 USA.4 aut
700	1	a Rice, Terriu Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut
700	1	a Swerdlow, Anthonyu Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England.;Inst Canc Res, Div Breast Canc Res, London SW3 6JB, England.4 aut
700	1	a Wiemels, Joseph L.u Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut
700	1	a Wiencke, John K.u Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut
700	1	a Shete, Sanjayu Univ Texas MD Anderson Canc Ctr, Dept Biostat, Orlando, TX USA.4 aut
700	1	a Xiang, Yong-Bingu Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, Dept Epidemiol,Renji Hosp, Shanghai 200030, Peoples R China.4 aut
700	1	a Xiao, Yuanyuanu Univ Calif San Francisco, San Francisco, CA 94143 USA.4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Fraumeni, Joseph F., Jr.4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a Hartge, Patriciau NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.4 aut
700	1	a Chanock, Stephen J.u NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.;NCI, Core Genotyping Facil, SAIC Frederick Inc, Gaithersburg, MD USA.4 aut
710	2	a NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA.;NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.b Onkologi4 org
773	0	t Human Geneticsd : SPRINGERg 131:12, s. 1877-1888q 131:12<1877-1888x 0340-6717x 1432-1203
856	4	u https://europepmc.org/articles/pmc3761216?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422339
856	4 8	u https://doi.org/10.1007/s00439-012-1212-0
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60172
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:125557180

Hitta via bibliotek

Human Genetics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Rajaraman, Preet ...; Melin, Beatrice ...; Wang, Zhaoming; McKean-Cowdin, R ...; Michaud, Dominiq ...; Wang, Sophia S.; visa fler...; Bondy, Melissa; Houlston, Richar ...; Jenkins, Robert ...; Wrensch, Margare ...; Yeager, Meredith; Ahlbom, Anders; Albanes, Demetri ...; Andersson, Ulrik ...; Freeman, Laura E ...; Buring, Julie E.; Butler, Mary Ann; Braganza, Meliss ...; Carreon, Tania; Feychting, Maria; Fleming, Sarah J ...; Gapstur, Susan M ...; Gaziano, J. Mich ...; Giles, Graham G.; Hallmans, Göran; Henriksson, Roge ...; Hoffman-Bolton, ...; Inskip, Peter D.; Johansen, Christ ...; Kitahara, Cari M ...; Lathrop, Mark; Liu, Chenwei; Le Marchand, Loi ...; Linet, Martha S.; Lonn, Stefan; Peters, Ulrike; Purdue, Mark P.; Rothman, Nathani ...; Ruder, Avima M.; Sanson, Marc; Sesso, Howard D.; Severi, Gianluca; Shu, Xiao-Ou; Simon, Matthias; Stampfer, Meir; Stevens, Victori ...; Visvanathan, Kal ...; White, Emily; Wolk, Alicja; Zeleniuch-Jacquo ...; Zheng, Wei; Decker, Paul; Enciso-Mora, Vic ...; Fridley, Brooke; Gao, Yu-Tang; Kosel, Matthew; Lachance, Daniel ...; Lau, Ching; Rice, Terri; Swerdlow, Anthon ...; Wiemels, Joseph ...; Wiencke, John K.; Shete, Sanjay; Xiang, Yong-Bing; Xiao, Yuanyuan; Hoover, Robert N ...; Fraumeni, Joseph ...; Chatterjee, Nila ...; Hartge, Patricia; Chanock, Stephen ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

Artiklar i publikationen: Human Genetics

Av lärosätet: Uppsala universitet; Umeå universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se