WFRF:(Isaksson Olle 1943)
Sökning: WFRF:(Isaksson Olle 1943) > Possible roles of i...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04141naa a2200637 4500 | |
| 001 | oai:gup.ub.gu.se/75384 | |
| 003 | SwePub | |
| 008 | 240528s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/753842 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Skrtic, Stanko,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology4 aut0 (Swepub:gu)xskrst |
| 245 | 1 0 | a Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth. |
| 264 | 1 | c 2001 |
| 520 | a BACKGROUND/AIMS: Almost all circulating insulin-like growth factor-1 (IGF-1) is produced and secreted from the liver. However, the possible role of IGF-1 in local regulation of liver functions including liver growth is unclear. In the present study, we investigated the role of IGF-1 on liver growth in vivo and in hepatic stellate cell function in vitro. RESULTS: Liver-specific knock-out of the IGF-1 gene by use of the cre-loxP system caused enhanced liver growth, possibly reflecting increased growth hormone (GH) secretion due to decreased negative feedback by IGF-1. Studies on cultured rat hepatic stellate cells (HSC) showed that IGF-1 and hepatocyte-conditioned medium (PCcM) time- and dose-dependently increased hepatocyte growth factor (HGF) mRNA and HGF immunoreactivity. IGF-1 and PCcM also enhanced DNA synthesis in the HSC cultures. The PCcM did not contain bioactive IGF-1 and was also able to stimulate proliferation when prepared under serum- and hormone-free conditions. CONCLUSION: In vivo results show that IGF-1 is not essential for normal growth of the intact liver. The in vitro results indicate that both IGF-1 and IGF- 1-independent factor(s) from hepatocytes can stimulate HGF production by HSC. It remains to be investigated whether these effects are of importance for liver regeneration or pathological conditions. | |
| 653 | a Animals | |
| 653 | a Cell Division | |
| 653 | a physiology | |
| 653 | a Culture Media | |
| 653 | a Conditioned | |
| 653 | a pharmacology | |
| 653 | a DNA | |
| 653 | a biosynthesis | |
| 653 | a Hepatocyte Growth Factor | |
| 653 | a biosynthesis | |
| 653 | a genetics | |
| 653 | a Hepatocytes | |
| 653 | a cytology | |
| 653 | a pathology | |
| 653 | a Liver | |
| 653 | a cytology | |
| 653 | a growth & development | |
| 653 | a metabolism | |
| 653 | a pathology | |
| 653 | a Liver Diseases | |
| 653 | a physiopathology | |
| 653 | a Mice | |
| 653 | a Mice | |
| 653 | a Knockout | |
| 653 | a genetics | |
| 653 | a Mitogens | |
| 653 | a pharmacology | |
| 653 | a Somatomedins | |
| 653 | a deficiency | |
| 653 | a physiology | |
| 700 | 1 | a Wallenius, Kristina,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut |
| 700 | 1 | a Sjögren, Klara,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xsjokl |
| 700 | 1 | a Isaksson, Olle,d 1943u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xisaol |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xjanjo |
| 710 | 2 | a Göteborgs universitetb Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi4 org |
| 773 | 0 | t Hormone researchg 55 Suppl 1, s. 1-6q 55 Suppl 1<1-6x 0301-0163 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/75384 |
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