Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin

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Monocyte chemoattractant protein-1 in subcutaneous abdominal adipose tissue: characterization of interstitial concentration and regulation of gene expression by insulin

Murdolo, Giuseppe, 1966 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Hammarstedt, Ann, 1975 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Sandqvist, Madelene, 1974 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

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Schmelz, M. (författare)

Herder, C. (författare)

Smith, Ulf, 1943 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

Jansson, Per-Anders, 1961 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine

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The Endocrine Society, 2007
2007
Engelska.
Ingår i: J Clin Endocrinol Metab. - : The Endocrine Society. - 0021-972X. ; 92:7, s. 2688-95

Relaterad länk:: https://academic.oup...; visa fler...; https://gup.ub.gu.se...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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CONTEXT: The chemokine monocyte chemoattractant protein-1 (MCP-1) is implicated in obesity-associated chronic inflammation, insulin resistance, and atherosclerosis. OBJECTIVES: The objectives of this study were to: 1) characterize the interstitial levels and the gene expression of MCP-1 in the sc abdominal adipose tissue (SCAAT), 2) elucidate the response of MCP-1 to acute hyperinsulinemia, and 3) determine the relationship between MCP-1 and arterial stiffness. DESIGN: Nine lean (L) and nine uncomplicated obese (OB) males were studied in the fasting state and during a euglycemic-hyperinsulinemic clamp combined with the microdialysis technique. Interstitial and serum MCP-1 (iMCP-1 and sMCP-1, respectively) levels, pulse wave analysis, and SCAAT biopsies were characterized at baseline and after hyperinsulinemia. RESULTS: OB showed elevated sMCP-1 (P < 0.01) but similar iMCP-1 levels as compared with L. Basal iMCP-1 concentrations were considerably higher than sMCP-1 (P < 0.0001), and a gradient between iMCP-1 and sMCP-1 levels was maintained throughout the hyperinsulinemia. At baseline, SCAAT gene expression profile revealed a "co-upregulation" of MCP-1, MCP-2, macrophage inflammatory protein-1alpha, and CD68 in OB, and whole-body glucose disposal inversely correlated with the MCP-1 gene expression. After hyperinsulinemia, MCP-1 and MCP-2 mRNA levels significantly increased in L, but not in OB. Finally, sMCP-1 excess in the OB positively correlated with the stiffer vasculature. CONCLUSIONS: These observations demonstrate similar interstitial concentrations and a differential gene response to hyperinsulinemia of MCP-1 in the SCAAT from L and OB individuals. In human obesity, we suggest the SCAAT MCP-1 gene overexpression as a biomarker of an "inflamed" adipose organ and impaired glucose metabolism.

Nyckelord

Adipocytes/cytology/physiology
Adult
Biological Markers
Cell Size
Chemokine CCL2/*genetics
Diabetes Mellitus
Type 2/*genetics/immunology/physiopathology
Gene Expression Profiling
Gene Expression Regulation/immunology
*Genetic Markers
Humans
Hyperinsulinism/genetics/immunology/physiopathology
Insulin/*blood
Insulin Resistance
Male
Middle Aged
Obesity/genetics/immunology/physiopathology
Subcutaneous Fat/*physiology

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Av författaren/redakt...: Murdolo, Giusepp ...; Hammarstedt, Ann ...; Sandqvist, Madel ...; Schmelz, M.; Herder, C.; Smith, Ulf, 1943; visa fler...; Jansson, Per-And ...; visa färre...

Artiklar i publikationen: J Clin Endocrino ...; The Journal of C ...

Av lärosätet: Göteborgs universitet

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