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WFRF:(Molinuevo José Luis)
 

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FältnamnIndikatorerMetadata
00010513naa a2200901 4500
001oai:DiVA.org:oru-79152
003SwePub
008200114s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:141093579
009oai:gup.ub.gu.se/281592
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-791522 URI
0247 a https://doi.org/10.1016/j.jalz.2019.01.0152 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410935792 URI
0247 a https://gup.ub.gu.se/publication/2815922 URI
040 a (SwePub)orud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lleó, Albertou Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain4 aut
2451 0a Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study
264 c 2019-04-06
264 1b Elsevier,c 2019
338 a print2 rdacarrier
500 a Funding Agencies:Ministry of Health, Italy, Appeared in article as Italian Ministry of HealthNetherlands Organization for Health Research and Development, Appeared in article as Netherlands Organization for Health, Research and Development (ZonMw)Instituto de Salud Carlos III, Appeared in article as Instituto de Salud Carlos III, Grant numbers PI14/1561, PI17/1895Fondo Europeo de Desarrollo Regional (FEDER), Union Europea, "Una manera de hacer Europa"Federal Ministry of Education & Research (BMBF), Appeared in article as Bundesministerium fur Bildung und Forschung (BMBF), GermanySwedish Research Council, Appeared in article as Swedish Research CouncilInnovation Fund Denmark, Grant number 0603-00470BFonds de Recherche du Quebec-Sante (FRQS)J. L. Levesque Foundation  Department of Health of the Basque Government, Grant number 2016111096Instituto de Salud Carlos III, Appeared in article as Carlos III Institute of Health, Grant number PI15/00919"Obra Social Kutxa Fundazioa"European Research Council (ERC), Appeared in article as European Research Council, Grant number 681712Swedish Research Council, Appeared in article as Swedish Research Council, Grant number 2013-2546Torsten Soderberg Foundation at the Royal Swedish Academy of Sciences  European Union (EU), Appeared in article as European Commission as part of the 6th Framework Program, Grant number 37670
520 a INTRODUCTION: Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined.METHODS: We included 467 subjects from the BIOMARKAPD study with at least two serial CSF samples. Diagnoses were subjective cognitive decline (n = 75), mild cognitive impairment (n = 128), and AD dementia (n = 110), and a group of cognitively unimpaired subjects (n = 154) were also included. We measured baseline and follow-up CSF levels of total tau (t-tau), phosphorylated tau (p-tau), YKL-40, and neurofilament light (NfL). Median CSF sampling interval was 2.1 years.RESULTS: CSF levels of t-tau, p-tau, NfL, and YKL-40 were 2% higher per each year of baseline age in controls (P <.001). In AD, t-tau levels were 1% lower (P <.001) and p-tau levels did not change per each year of baseline age. Longitudinally, only NfL (P <.001) and YKL-40 (P <.02) increased during the study period.DISCUSSION: All four CSF biomarkers increase with age, but this effect deviates in AD for t-tau and p-tau.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer
653 a Amyloid
653 a CSF
653 a Inflammation
653 a Neurofilaments
653 a Tau
653 a YKL-40
653 a Alzheimer
653 a Amyloid
653 a CSF
653 a Inflammation
653 a Neurofilaments
653 a Tau
653 a YKL-40
7001 a Alcolea, Danielu Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain4 aut
7001 a Martínez-Lage, Pablou Center for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain4 aut
7001 a Scheltens, Philipu Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands4 aut
7001 a Parnetti, Lucillau Centre for Memory Disturbances, Section of Neurology, Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy4 aut
7001 a Poirier, Judesu Karolinska Institutet4 aut
7001 a Simonsen, Anja H.u Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Verbeek, Marcel M.u Department of Neurology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Nijmegen, the Netherlands4 aut
7001 a Rosa-Neto, Pedrou Centre for the Studies on the Prevention of Alzheimer's Disease, Douglas Mental Health University Institute, Montréal, QC, Canada4 aut
7001 a Slot, Rosalinde E.R.u Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands4 aut
7001 a Tainta, Mikelu Center for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain4 aut
7001 a Izaguirre, Andreau Center for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain4 aut
7001 a Reijs, Babette L.R.u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands4 aut
7001 a Farotti, Luciau Centre for Memory Disturbances, Section of Neurology, Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy4 aut
7001 a Tsolaki, Magdau 1st Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, Makedonia, Greece; Alzheimer Hellas, Thessaloniki, Greece4 aut
7001 a Vandenbergue, Riku University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium4 aut
7001 a Freund-Levi, Yvonne,d 1956-u Department of Neurobiology, Care Sciences and Society, Karolinska Institutet Center for Alzheimer Research, Division of Clinical Geriatrics, Huddinge; Department of Old Age Psychiatry, Psychology and Neuroscience, King's College London, London, UK4 aut0 (Swepub:oru)yfi
7001 a Verhey, Frans R.J.u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands4 aut
7001 a Clarimón, Jordiu Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain4 aut
7001 a Fortea, Juanu Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spain4 aut
7001 a Frolich, Lutzu Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany4 aut
7001 a Santana, Isabelu Dementia Clinic, Centro Hospitalar e Universitário de Coimbra and Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal4 aut
7001 a Molinuevo, José Luisu ICN Hospital Clinic i Universitari, Barcelona, Spain4 aut
7001 a Lehmann, Sylvainu Univ Montpellier, CHU Montpellier, Montpellier, France4 aut
7001 a Visser, Pieter J.u Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands4 aut
7001 a Teunissen, Charlotte E.u Amsterdam UMC, Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands4 aut
7001 a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
7001 a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
7102 a Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain; Centre of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), Madrid, Spainb Center for Research and Advanced Therapies, Fundación CITA-alzheimer Fundazioa, San Sebastian, Spain4 org
7730 t Alzheimer's & Dementiad : Elsevierg 15:6, s. 742-753q 15:6<742-753x 1552-5260x 1552-5279
8564 u https://discovery.ucl.ac.uk/10073502/3/Zetterberg%20Lleo.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79152
8564 8u https://doi.org/10.1016/j.jalz.2019.01.015
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141093579
8564 8u https://gup.ub.gu.se/publication/281592

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