Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients

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Intramuscular Stimulation of Muscle Afferents Attains Prolonged Tremor Reduction in Essential Tremor Patients

Pascual-Valdunciel, Alejandro (författare): CSIC - Instituto Cajal (IC),Cajal Institute,Universidad Politecnica de Madrid,Technical University of Madrid

Gonzalez-Sanchez, Miguel (författare): Hospital General Universitario Gregorio Maranon

Muceli, Silvia, 1981 (författare): Chalmers tekniska högskola,Chalmers University of Technology

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Adan-Barrientos, Beatriz (författare): Universidad Carlos Iii De Madrid

Escobar-Segura, Viviana (författare): Universidad Complutense de Madrid,Complutense University

Perez-Sanchez, Javier Ricardo (författare): Hospital General Universitario Gregorio Maranon

Jung, Moon Ki (författare): Imperial College of Science, Technology and Medicine

Schneider, Andreas (författare): Fraunhofer-Institut fur Biomedizinische Technik (IBMT),Fraunhofer Institute for Biomedical Engineering (IBMT)

Hoffmann, Klaus Peter (författare): Fraunhofer-Institut fur Biomedizinische Technik (IBMT),Fraunhofer Institute for Biomedical Engineering (IBMT)

Moreno, Juan Camilo (författare): CSIC - Instituto Cajal (IC),Cajal Institute

Grandas, Francisco (författare): Hospital General Universitario Gregorio Maranon,Universidad Complutense de Madrid,Complutense University

Farina, Dario (författare): Imperial College of Science, Technology and Medicine

Pons, Jose L. (författare): CSIC - Instituto Cajal (IC),Cajal Institute,Northwestern University

Barroso, Filipe O. (författare): CSIC - Instituto Cajal (IC),Cajal Institute

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(creator_code:org_t)

2021
2021
Engelska.
Ingår i: IEEE Transactions on Biomedical Engineering. - 0018-9294 .- 1558-2531. ; 68:6, s. 1768-1776

Relaterad länk:: https://research.cha... (primary) (free); visa fler...; https://research.cha...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

This study proposes and clinically tests intramuscular electrical stimulation below motor threshold to achieve prolonged reduction of wrist flexion/extension tremor in Essential Tremor (ET) patients. The developed system consisted of an intramuscular thin-film electrode structure that included both stimulation and electromyography (EMG) recording electrodes, and a control algorithm for the timing of intramuscular stimulation based on EMG (closed-loop stimulation). Data were recorded from nine ET patients with wrist flexion/extension tremor recruited from the Gregorio Marañón Hospital (Madrid, Spain). Patients participated in two experimental sessions comprising: 1) sensory stimulation of wrist flexors/extensors via thin-film multichannel intramuscular electrodes; and 2) surface stimulation of the nerves innervating the same target muscles. For each session, four of these patients underwent random 60-s trials of two stimulation strategies for each target muscle: 1) selective and adaptive timely stimulation (SATS) - based on EMG of the antagonist muscle; and 2) continuous stimulation (CON) of target muscles. Two patients underwent SATS stimulation trials alone while the other three underwent CON stimulation trials alone in each session. Kinematics of wrist, elbow, and shoulder, together with clinical scales, were used to assess tremor before, right after, and 24 h after each session. Intramuscular SATS achieved, on average, 32% acute (during stimulation) tremor reduction on each trial, while continuous stimulation augmented tremorgenic activity. Furthermore, tremor reduction was significantly higher using intramuscular than surface stimulation. Prolonged reduction of tremor amplitude (24 h after the experiment) was observed in four patients. These results showed acute and prolonged (24 h) tremor reduction using a minimally invasive neurostimulation technology based on SATS of primary sensory afferents of wrist muscles. This strategy might open the possibility of an alternative therapeutic approach for ET patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Intramuscular
Tremor reduction
Essential tremor
Neuromodulation
Sensory stimulation

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Av författaren/redakt...: Pascual-Valdunci ...; Gonzalez-Sanchez ...; Muceli, Silvia, ...; Adan-Barrientos, ...; Escobar-Segura, ...; Perez-Sanchez, J ...; visa fler...; Jung, Moon Ki; Schneider, Andre ...; Hoffmann, Klaus ...; Moreno, Juan Cam ...; Grandas, Francis ...; Farina, Dario; Pons, Jose L.; Barroso, Filipe ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Oto rhino laryng ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

Artiklar i publikationen: IEEE Transaction ...

Av lärosätet: Chalmers tekniska högskola

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