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Sökning: onr:"swepub:oai:DiVA.org:liu-23810" > Photodynamic therap...

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FältnamnIndikatorerMetadata
00006852naa a2200589 4500
001oai:DiVA.org:liu-23810
003SwePub
008091007s2004 | |||||||||||000 ||eng|
009oai:research.chalmers.se:973fca9b-848d-40ba-b7b1-88620c86de0c
009oai:gup.ub.gu.se/43612
009oai:research.chalmers.se:32b924c6-f806-4d11-99cf-e37692742b9d
009oai:prod.swepub.kib.ki.se:1955323
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-238102 URI
0247 a https://doi.org/10.1111/j.1365-2133.2004.06211.x2 DOI
0247 a https://research.chalmers.se/publication/129362 URI
0247 a https://gup.ub.gu.se/publication/436122 URI
0247 a https://research.chalmers.se/publication/436122 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19553232 URI
040 a (SwePub)liud (SwePub)cthd (SwePub)gud (SwePub)cthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ericson, Marica,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology,University of Gothenburg4 aut0 (Swepub:gu)xemarq
2451 0a Photodynamic therapy of actinic keratosis at varying fluence rates :b Assessment of photobleaching, pain and primary clinical outcome
264 1b Oxford University Press (OUP),c 2004
338 a print2 rdacarrier
520 a Background: Although photodynamic therapy (PDT) is becoming an important treatment method for skin lesions such as actinic keratosis (AK) and superficial basal cell carcinoma, there are still discussions about which fluence rate and light dose are preferable. Recent studies in rodents have shown that a low fluence rate is preferable due to depletion of oxygen at high fluence rates. However, these results have not yet been verified in humans. Objectives: The objective was to investigate the impact of fluence rate and spectral range on primary treatment outcome and bleaching rate in AK using aminolaevulinic acid PDT. In addition, the pain experienced by the patients has been monitored during treatment. Patients/methods Thirty-seven patients (mean age 71 years) with AK located on the head, neck and upper chest were treated with PDT, randomly allocated to four groups: two groups with narrow filter (580-650 nm) and fluence rates of 30 or 45 mW cm-2, and two groups with broad filter (580-690 nm) and fluence rates of 50 or 75 mW cm-2. The total cumulative light dose was 100 J cm-2 in all treatments. Photobleaching was monitored by fluorescence imaging, and pain experienced by the patients was registered by using a visual analogue scale graded from 0 (no pain) to 10 (unbearable pain). The primary treatment outcome was evaluated at a follow-up visit after 7 weeks. Results: Our data showed a significant correlation between fluence rate and initial treatment outcome, where lower fluence rate resulted in favourable treatment response. Moreover, the photo-bleaching dose (1/e) was found to be related to fluence rate, ranging from 4.5 ± 1.0 J cm -2 at 30 mW cm-2, to 7.3 ± 0.7 J cm-2 at 75 mW cm-2, indicating higher oxygen levels in tissue at lower fluence rates. After a cumulative light dose of 40 J cm-2 no further photobleaching took place, implying that higher doses are excessive. No significant difference in pain experienced by the patients during PDT was observed in varying the fluence rate from 30 to 75 mW cm-2. However, the pain was found to be most intense up to a cumulative light dose of 20 J cm-2. Conclusions: Our results imply that the photobleaching rate and primary treatment outcome are dependent on fluence rate, and that a low fluence rate (30 mW cm-2) seems preferable when performing PDT of AK using noncoherent light sources.
650 7a TEKNIK OCH TEKNOLOGIERx Annan teknik0 (SwePub)2112 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Other Engineering and Technologies0 (SwePub)2112 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
653 a MEDICINE
653 a MEDICIN
7001 a Sandberg, Carin,d 1969u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology,University of Gothenburg4 aut0 (Swepub:gu)xwenna
7001 a Stenquist, Bu Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology,University of Gothenburg4 aut
7001 a Gudmundson, Fu Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU),University of Gothenburg4 aut
7001 a Karlsson, Mu Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Department of Physics (GU),University of Gothenburg4 aut
7001 a Ros, A-M4 aut
7001 a Rosen, Arne,d 1939u Chalmers tekniska högskola,Chalmers University of Technology,Göteborgs universitet,University of Gothenburg4 aut0 (Swepub:gu)xrosar
7001 a Larkö, Olle,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology,University of Gothenburg4 aut0 (Swepub:gu)xlarol
7001 a Wennberg, A-M4 aut
7001 a Rosdahl, Inger,d 1943-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för dermatologi och venereologi,Hudkliniken i Östergötland4 aut0 (Swepub:liu)ingro22
7102 a Göteborgs universitetb Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi4 org
7730 t British Journal of Dermatologyd : Oxford University Press (OUP)g 151, s. 1204-1212q 151:6<1204-1212x 0007-0963x 1365-2133
7730 t Br. J. Dermatold : Oxford University Press (OUP)g 151, s. 1204-1212q 151<1204-1212
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-23810
8564 8u https://doi.org/10.1111/j.1365-2133.2004.06211.x
8564 8u https://research.chalmers.se/publication/12936
8564 8u https://gup.ub.gu.se/publication/43612
8564 8u https://research.chalmers.se/publication/43612
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1955323

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