WFRF:(Rydén Ingvar)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02884naa a2200313 4500 | |
| 001 | oai:DiVA.org:liu-25259 | |
| 003 | SwePub | |
| 008 | 091007s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-252592 URI |
| 024 | 7 | a https://doi.org/10.1016/S0009-8981(01)00803-82 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Rydén, Ingvaru Department of Clinical Chemistry, Kalmar County Hospital, Sweden4 aut |
| 245 | 1 0 | a Fucosylation of α1-acid glycoprotein (orosomucoid) compared with traditional biochemical markers of inflammation in recent onset rheumatoid arthritis |
| 264 | 1 | c 2002 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: Fucosylation of α1-acid glycoprotein (AGP, orosomucoid) has previously been found to be increased in patients with rheumatoid arthritis. Furthermore, the degree of fucosylation has been suggested to reflect disease activity. Therefore, we investigated the fucosylation of AGP in 131 patients (96 women and 35 men) with recent onset rheumatoid arthritis (RA). We compared the results with traditional biochemical markers of inflammation, i.e. plasma concentrations of AGP (P-AGP), and C-reactive protein (P-CRP).Methods: AGP fucosylation measured with a novel lectin enzyme-linked immunosorbent assay (ELISA) was compared with a disease activity score (DAS28) and its components, and with P-AGP, and P-CRP at the time of diagnosis, and at a follow-up visit 1 year later.Results: Both men and women with RA had increased AGP fucosylation compared to healthy individuals. We found a weak correlation between AGP fucosylation and DAS28 only in men. In men with initially increased AGP fucosylation, the level of fucosylation correlated with the change in DAS28 during the first year following diagnosis. Conclusion: We conclude that AGP fucosylation is not superior to traditional markers of disease activity in RA. However, AGP fucosylation may give some additional information to traditional biochemical markers on the disease progression in men. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Påhlsson, Peter,d 1962-u Linköpings universitet,Klinisk kemi,Hälsouniversitetet4 aut0 (Swepub:liu)petpa61 |
| 700 | 1 | a Lundblad, Arne,d 1937-u Linköpings universitet,Klinisk kemi,Hälsouniversitetet4 aut0 (Swepub:liu)arnlu37 |
| 700 | 1 | a Skogh, Thomas,d 1952-u Linköpings universitet,Reumatologi,Hälsouniversitetet4 aut0 (Swepub:liu)thosk00 |
| 710 | 2 | a Department of Clinical Chemistry, Kalmar County Hospital, Swedenb Klinisk kemi4 org |
| 773 | 0 | t Clinica Chimica Actag 317:1-2, s. 221-229q 317:1-2<221-229x 0009-8981x 1873-3492 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25259 |
| 856 | 4 8 | u https://doi.org/10.1016/S0009-8981(01)00803-8 |
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