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FältnamnIndikatorerMetadata
00003997naa a2200517 4500
001oai:DiVA.org:liu-66972
003SwePub
008110323s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:124517087
009oai:DiVA.org:uu-174716
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-669722 URI
0247 a https://doi.org/10.1093/schbul/sbq0862 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1245170872 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1747162 URI
040 a (SwePub)liud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Linderholm, Klas Ru Department of Physiology and Pharmacology, Karolinska Institutet4 aut
2451 0a Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
264 c 2010-08-20
264 1b Oxford University Press,c 2012
338 a print2 rdacarrier
520 a Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and alpha7* nicotinic receptors. Methods: The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA and its precursors, kynurenine (KYN) and TRP, in the cerebrospinal fluid (CSF) of patients with schizophrenia. CSF from male patients with schizophrenia on olanzapine treatment (n = 16) was compared with healthy male volunteers (n = 29). Results: KYN and KYNA concentrations were higher in patients with schizophrenia (60.7 +/- 4.37nM and 2.03 +/- 0.23nM, respectively) compared with healthy volunteers (28.6 +/- 1.44nM and 1.36 +/- 0.08nM, respectively), whereas TRP did not differ between the groups. In all subjects, KYN positively correlated to KYNA. Conclusion: Our results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
653 a psychosis
653 a kynurenate
653 a olanzapine
653 a cerebrospinal fluid
653 a tryptophan
653 a MEDICINE
653 a MEDICIN
7001 a Skogh, Elisabethu Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken4 aut0 (Swepub:liu)elisk66
7001 a Olsson, Sara Ku Department of Physiology and Pharmacology, Karolinska Institutet4 aut
7001 a Dahl, Marja-Liisau Uppsala universitet,Karolinska Institutet,Department of Medical Sciences, Clinical Pharmacology, Uppsala University,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)madah516
7001 a Holtze, Mariau Department of Physiology and Pharmacology, Karolinska Institutet4 aut
7001 a Engberg, Göranu Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet4 aut
7001 a Samuelsson, Martinu Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken4 aut0 (Swepub:liu)marsa78
7001 a Erhardt, Sophieu Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet4 aut
7102 a Department of Physiology and Pharmacology, Karolinska Institutetb Psykiatri4 org
7730 t Schizophrenia Bulletind : Oxford University Pressg 38:3, s. 426-432q 38:3<426-432x 0586-7614x 1745-1701
8564 u https://academic.oup.com/schizophreniabulletin/article-pdf/38/3/426/5264402/sbq086.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66972
8564 8u https://doi.org/10.1093/schbul/sbq086
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:124517087
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174716

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