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  • Hayashi, Shirley YumiDivision of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital (författare)

Improvement of cardiac function after haemodialysis : Quantitative evaluation by colour tissue velocity imaging

  • Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

  • 2004-03-19
  • Oxford University Press (OUP),2004
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-8354
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-8354URI
  • https://doi.org/10.1093/ndt/gfh205DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1952531URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20100809
  • Background. Overhydration and accumulation of uraemic toxins may influence the myocardial function in haemodialysis (HD) patients. To evaluate cardiac function and the effects of fluid and solute removal during a single session of HD, colour tissue velocity imaging (TVI) was used. This new technique, which is less load dependent than conventional echocardiography, allows an objective quantitative assessment of myocardial contractility, contraction and relaxation. Methods. Conventional echocardiographic and TVI images were recorded before and after a single HD session in 13 clinically stable HD patients (62 +/- 10 years, six males) and in 13 sex- and age-matched healthy controls. Myocardial tissue velocities (v; cm/s) for isovolumetric contraction (IVC), peak systole (PS), early (E) and late (A') diastolic filling and strain rate (SR) were measured. Results. Left ventricular hypertrophy (LVH) was present in 12 patients. TVI gave additional information in comparison with conventional echocardiography. Before HD, PS (5.0 +/- 0.8 vs 6.0 +/- 1.2 cm/s, P < 0.05), E' (5.7 +/- 1.7 vs 7.3 +/- 2.0 cm/s, P < 0.05) and A' (6.6 +/- 1.7 vs. 8.3 +/- 2.9 cm/s, P < 0.05) velocities were lower in the patients than in the controls, indicating systolic and diastolic dysfunction. The HD session increased IVCv (4.0 +/- 1.7 to 5.5 +/- 1.9 cm/s; P < 0.001), PSv (5.0 +/- 0.8 to 5.7 +/- 0.8 cm/s; P < 0.05) and SR (0.7 +/- 0.2 to 0.9 +/- 0.2 1/s; P < 0.05) and decreased E/E' (16.7 +/- 7.7 to 12.2 +/- 4.0, P < 0.05), indicating improved systolic function and decreased LV filling pressure, respectively. Linear regression analysis demonstrated a dependency of systolic contraction (PSv) and contractility (IVCv) upon plasma levels of phosphate (r(2) = 0.70, P < 0.005, r(2) = 0.33, P < 0.01). Conclusions. Using TVI, HD patients demonstrate myocardial dysfunction, which is found less frequently when using conventional echocardiography. The systolic function seems to be impaired by high plasma levels of phosphate and an increased Ca x P product. One single session of HD improved systolic function as indicated by increases in IVCv, PSv and SR. Further studies are needed to clarify if this effect of HD is due to the acute removal of fluid, the removal of solutes or both.

Ämnesord och genrebeteckningar

  • diastolic function; end-stage renal disease; haemodialysis; phosphate; systolic function; tissue Doppler echocardiography
  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brodin, Lars-ÅkeKarolinska Institutet(Swepub:kth)u1jq9s27 (författare)
  • Alvestrand, AndersKarolinska Institutet (författare)
  • Lind, BrittaDepartment of Clinical Physiology, Karolinska Institutet, Karolinska Univ. Hospital(Swepub:kth)u1sy2e01 (författare)
  • Stenvinkel, PeterKarolinska Institutet (författare)
  • Mazza do Nascimento, MarceloDivision of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital (författare)
  • Qureshi, Abdul RashidDivision of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital (författare)
  • Saha, SamirKarolinska Institutet (författare)
  • Lindholm, BengtKarolinska Institutet (författare)
  • Seeberger, AstridDivision of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital (författare)
  • Karolinska InstitutetDivision of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nephrology, Dialysis and Transplantation: Oxford University Press (OUP)19:6, s. 1497-15060931-05091460-2385

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