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FältnamnIndikatorerMetadata
00004884naa a2200469 4500
001oai:DiVA.org:kth-8354
003SwePub
008080507s2004 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1952531
024a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-83542 URI
024a https://doi.org/10.1093/ndt/gfh2052 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:19525312 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Hayashi, Shirley Yumiu Division of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital4 aut0 (Swepub:kth)u1ls2j0f
2451 0a Improvement of cardiac function after haemodialysis :b Quantitative evaluation by colour tissue velocity imaging
264 c 2004-03-19
264 1b Oxford University Press (OUP),c 2004
338 a print2 rdacarrier
500 a QC 20100809
520 a Background. Overhydration and accumulation of uraemic toxins may influence the myocardial function in haemodialysis (HD) patients. To evaluate cardiac function and the effects of fluid and solute removal during a single session of HD, colour tissue velocity imaging (TVI) was used. This new technique, which is less load dependent than conventional echocardiography, allows an objective quantitative assessment of myocardial contractility, contraction and relaxation. Methods. Conventional echocardiographic and TVI images were recorded before and after a single HD session in 13 clinically stable HD patients (62 +/- 10 years, six males) and in 13 sex- and age-matched healthy controls. Myocardial tissue velocities (v; cm/s) for isovolumetric contraction (IVC), peak systole (PS), early (E) and late (A') diastolic filling and strain rate (SR) were measured. Results. Left ventricular hypertrophy (LVH) was present in 12 patients. TVI gave additional information in comparison with conventional echocardiography. Before HD, PS (5.0 +/- 0.8 vs 6.0 +/- 1.2 cm/s, P < 0.05), E' (5.7 +/- 1.7 vs 7.3 +/- 2.0 cm/s, P < 0.05) and A' (6.6 +/- 1.7 vs. 8.3 +/- 2.9 cm/s, P < 0.05) velocities were lower in the patients than in the controls, indicating systolic and diastolic dysfunction. The HD session increased IVCv (4.0 +/- 1.7 to 5.5 +/- 1.9 cm/s; P < 0.001), PSv (5.0 +/- 0.8 to 5.7 +/- 0.8 cm/s; P < 0.05) and SR (0.7 +/- 0.2 to 0.9 +/- 0.2 1/s; P < 0.05) and decreased E/E' (16.7 +/- 7.7 to 12.2 +/- 4.0, P < 0.05), indicating improved systolic function and decreased LV filling pressure, respectively. Linear regression analysis demonstrated a dependency of systolic contraction (PSv) and contractility (IVCv) upon plasma levels of phosphate (r(2) = 0.70, P < 0.005, r(2) = 0.33, P < 0.01). Conclusions. Using TVI, HD patients demonstrate myocardial dysfunction, which is found less frequently when using conventional echocardiography. The systolic function seems to be impaired by high plasma levels of phosphate and an increased Ca x P product. One single session of HD improved systolic function as indicated by increases in IVCv, PSv and SR. Further studies are needed to clarify if this effect of HD is due to the acute removal of fluid, the removal of solutes or both.
653 a diastolic function; end-stage renal disease; haemodialysis; phosphate; systolic function; tissue Doppler echocardiography
653 a MEDICINE
653 a MEDICIN
700a Brodin, Lars-Åkeu Karolinska Institutet4 aut0 (Swepub:kth)u1jq9s27
700a Alvestrand, Andersu Karolinska Institutet4 aut
700a Lind, Brittau Department of Clinical Physiology, Karolinska Institutet, Karolinska Univ. Hospital4 aut0 (Swepub:kth)u1sy2e01
700a Stenvinkel, Peteru Karolinska Institutet4 aut
700a Mazza do Nascimento, Marcelou Division of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital4 aut
700a Qureshi, Abdul Rashidu Division of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital4 aut
700a Saha, Samiru Karolinska Institutet4 aut
700a Lindholm, Bengtu Karolinska Institutet4 aut
700a Seeberger, Astridu Division of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital4 aut
710a Karolinska Institutetb Division of Baxter Novum, Department of Clinical Science, Karolinska Univ. Hospital4 org
773t Nephrology, Dialysis and Transplantationd : Oxford University Press (OUP)g 19:6, s. 1497-1506q 19:6<1497-1506x 0931-0509x 1460-2385
856u https://academic.oup.com/ndt/article-pdf/19/6/1497/5255503/gfh205.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-8354
8564 8u https://doi.org/10.1093/ndt/gfh205
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1952531

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