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Sökning: WFRF:(Ytterberg C) > (2015-2019) > Shared immunologica...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004332naa a2200517 4500
001oai:DiVA.org:uu-239509
003SwePub
008141229s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:131776284
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2395092 URI
0247 a https://doi.org/10.1136/annrheumdis-2013-2049122 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1317762842 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ytterberg, A Jimmyu Karolinska Institutet4 aut
2451 0a Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis :b identification and validation
264 c 2014-05-09
264 1b BMJ,c 2015
338 a print2 rdacarrier
520 a OBJECTIVES: Immunological events in the lungs might trigger production of anti-citrullinated protein antibodies during early rheumatoid arthritis (RA). We investigated the presence of shared immunological citrullinated targets in joints and lungs of patients with RA.PATIENTS AND METHODS: Proteins extracted from bronchial (n=6) and synovial (n=7) biopsy specimens from patients with RA were investigated by mass spectrometry-based proteomics. One candidate peptide was synthesised and used to investigate by ELISA the presence of antibodies in patients with RA (n=393), healthy controls (n=152) and disease controls (n=236). HLA-DRB1 shared epitope (SE) alleles were detected in patients with RA.RESULTS: Ten citrullinated peptides belonging to seven proteins were identified, with two peptides shared between the synovial and bronchial biopsy samples. Further analysis, using accurate mass and retention time, enabled detection of eight citrullinated peptides in synovial and seven in bronchial biopsy specimens, with five peptides shared between the synovial and bronchial biopsy specimens. Two citrullinated vimentin (cit-vim) peptides were detected in the majority of synovial and lung tissues. Antibodies to a synthesised cit-vim peptide candidate (covering both cit-vim peptides identified in vivo) were present in 1.8% of healthy controls, 15% of patients with RA, and 3.4% of disease controls. Antibodies to cit-vim peptide were associated with the presence of the SE alleles in RA.CONCLUSIONS: Identical citrullinated peptides are present in bronchial and synovial tissues, which may be used as immunological targets for antibodies of patients with RA. The data provide further support for a link between lungs and joints in RA and identify potential targets for immunity that may mediate this link.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
7001 a Joshua, Vijayu Karolinska Institutet4 aut
7001 a Reynisdottir, Gudrun4 aut
7001 a Tarasova, Nataliya Ku Karolinska Institutet4 aut
7001 a Rutishauser, Dorothea4 aut
7001 a Ossipova, Elena4 aut
7001 a Haj Hensvold, Aaseu Karolinska Institutet4 aut
7001 a Eklund, Andersu Karolinska Institutet4 aut
7001 a Sköld, C Magnusu Karolinska Institutet4 aut
7001 a Grunewald, Johanu Karolinska Institutet4 aut
7001 a Malmström, Vivianneu Karolinska Institutet4 aut
7001 a Jakobsson, Per Johanu Karolinska Institutet4 aut
7001 a Rönnelid, Johanu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)joharonn
7001 a Padyukov, Leonidu Karolinska Institutet4 aut
7001 a Zubarev, Roman Au Karolinska Institutet4 aut
7001 a Klareskog, Larsu Karolinska Institutet4 aut
7001 a Catrina, Anca Iu Karolinska Institutet4 aut
7102 a Karolinska Institutetb Klinisk immunologi4 org
7730 t Annals of the Rheumatic Diseasesd : BMJg 74:9, s. 1772-1777q 74:9<1772-1777x 0003-4967x 1468-2060
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-239509
8564 8u https://doi.org/10.1136/annrheumdis-2013-204912
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:131776284

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