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Current Progress To...
Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs : Summary Proceedings of the First Workshop on Drug Transporters in the Lungs
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- Ehrhardt, Carsten (författare)
- Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Pharm & Pharmaceut Sci, Dublin, Ireland.
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- Backman, Per (författare)
- Mylan Global Resp Grp, Sandwich, Kent, England.
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- Couet, William (författare)
- Univ Poitiers, CHU Poitiers, UFR Med Pharm, Inserm,U1070, Poitiers, France.
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- Edwards, Chris (författare)
- GlaxoSmithKline Medicines Res Ctr, Refractory Resp Inflammat DPU, Stevenage, Herts, England.
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- Forbes, Ben (författare)
- Kings Coll London, Inst Pharmaceut Sci, London, England.
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- Fridén, Markus (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,AstraZeneca R&D Gothenburg, Resp Inflammat & Autoimmun Innovat Med, Molndal, Sweden.,Translationell PKPD
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- Gumbleton, Mark (författare)
- Cardiff Univ, Sch Pharm & Pharmaceut Sci, Expt Therapeut, Cardiff, S Glam, Wales.
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- Hosoya, Ken-Ichi (författare)
- Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Pharmaceut, Toyama, Japan.
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- Kato, Yukio (författare)
- Kanazawa Univ, Fac Pharmaceut Sci, Dept Mol Pharmacotherapeut, Kanazawa, Ishikawa, Japan.
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- Nakanishi, Takeo (författare)
- Kanazawa Univ, Fac Pharmaceut Sci, Dept Membrane Transport & Biopharmaceut, Kanazawa, Ishikawa, Japan.
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- Takano, Mikihisa (författare)
- Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Hiroshima, Japan.
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- Terasaki, Tetsuya (författare)
- Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan.
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- Yumoto, Ryoko (författare)
- Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Hiroshima, Japan.
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Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Pharm & Pharmaceut Sci, Dublin, Ireland Mylan Global Resp Grp, Sandwich, Kent, England. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Journal of Pharmaceutical Sciences. - : Elsevier BV. - 0022-3549 .- 1520-6017. ; 106:9, s. 2234-2244
- Relaterad länk:
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http://jpharmsci.org...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The School of Pharmacy and Pharmaceutical Sciences at Trinity College Dublin hosted the "1st Workshop on Drug Transporters in the Lungs" in September 2016 to discuss the impact of transporters on pulmonary drug disposition and their roles as drug targets in lung disease. The workshop brought together about 30 scientists from academia and pharmaceutical industry from Europe and Japan and addressed the primary questions: What do we know today, and what do we need to know tomorrow about transporters in the lung? The 3 themes of the workshop were: (1) techniques to study drug transporter expression and actions in the lungs; (2) drug transporter effects on pulmonary pharmacokinetics-case studies; and (3) transporters as drug targets in lung disease. Some of the conclusions of the workshop were: suitable experimental models that allow studies of transporter effects are available; data from these models convincingly show a contribution of both uptake and efflux transporters on pulmonary drug disposition; the effects of transporters on drug lung PK is now better conceptualized; some transporters are associated with lung diseases. However, more work is needed to establish which of the available models best translate to the clinical situation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- absorption
- computational ADME
- efflux pumps
- in vitro models
- organic cation transporters
- P-glycoprotein
- peptide transporters
- pulmonary delivery/absorption
- ABC transporters
- organic anion-transporting polypeptide transporters
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ehrhardt, Carste ...
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Backman, Per
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Couet, William
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Edwards, Chris
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Forbes, Ben
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Fridén, Markus
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visa fler...
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Gumbleton, Mark
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Hosoya, Ken-Ichi
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Kato, Yukio
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Nakanishi, Takeo
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Takano, Mikihisa
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Terasaki, Tetsuy ...
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Yumoto, Ryoko
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visa färre...
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Uppsala universitet