Gut toxicity during hemopoietic stem cell transplantation may predict acute graft-versus-host disease severity in patients.

• Graft-versus-host disease (GVHD) is the primary complication of allogeneic, hemopoietic, stem cell transplantation (HSCT). Murine models suggest that gut toxicity, induced by the intensive chemotherapy preceding hematopoietic stem cell infusion, aggravates systemic GVHD. In HSCT patients gut toxicity correlates with chemotherapy intensity. The present study investigates acute GVHD severity and intestinal toxicity in patients undergoing allogeneic HSCT. In 38 patients intestinal permeability was assessed before and after chemotherapy (on days -1, +4, +7 and +14 as related to the stem cell infusion). Cumulative acute GVHD (days 0-100) and clinical intestinal toxicity (days 0-14) were evaluated in parallel. Patients with mild, acute GVHD (grades 0-I) had better-preserved intestinal barrier function (P=0.04) and less pronounced cumulative clinical intestinal toxicity (P=0.02) compared with patients with more severe acute GVHD (grades II-IV). Gut toxicity predicts acute GVHD severity. Therefore, gut protective strategies may diminish GVHD severity in allogeneic HSCT patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

Acute Disease

Adult

Female

Follow-Up Studies

Graft Rejection

prevention & control

Graft vs Host Disease

etiology

Hematopoietic Stem Cell Transplantation

adverse effects

Humans

Immunosuppressive Agents

adverse effects

Intestines

drug effects

metabolism

Leukemia

Myeloid

Chronic

surgery

Male

Middle Aged

Prognosis

Retrospective Studies

Risk Factors

Transplantation Conditioning

adverse effects

Transplantation

Homologous

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)