Minireview: liver X receptor beta: emerging roles in physiology and diseases

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Fältnamn	Indikatorer	Metadata
000		02189naa a2200277 4500
001		oai:prod.swepub.kib.ki.se:118192321
003		SwePub
008		240701s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1181923212 URI
024	7	a https://doi.org/10.1210/me.2008-03982 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gabbi, Cu Karolinska Institutet4 aut
245	1 0	a Minireview: liver X receptor beta: emerging roles in physiology and diseases
264	1	b The Endocrine Society,c 2009
520		a Liver X receptors, LXRα and LXRβ, are nuclear receptors belonging to the large family of transcription factors. After activation by oxysterols, LXRs play a central role in the control of lipid and carbohydrate metabolism as well as inflammation. The role of LXRα has been extensively studied, particularly in the liver and macrophages. In the liver it prevents cholesterol accumulation by increasing bile acid synthesis and secretion into the bile through ATP-binding cassette G5/G8 transporters, whereas in macrophages it increases cholesterol reverse transport. The function of LXRβ is still under investigation with most of the current knowledge coming from the study of phenotypes of LXRβ−/− mice. With these mice new emerging roles for LXRβ have been demonstrated in the pathogenesis of diseases such as amyotrophic lateral sclerosis and chronic pancreatitis. The present review will focus on the abnormalities described so far in LXRβ−/− mice and the insight gained into the possible roles of LXRβ in human diseases.
700	1	a Warner, M4 aut
700	1	a Gustafsson, JAu Karolinska Institutet4 aut
710	2	a Karolinska Institutet4 org
773	0	t Molecular endocrinology (Baltimore, Md.)d : The Endocrine Societyg 23:2, s. 129-136q 23:2<129-136x 0888-8809x 1944-9917
856	4	u https://academic.oup.com/mend/article-pdf/23/2/129/8941389/mend0129.pdf
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:118192321
856	4 8	u https://doi.org/10.1210/me.2008-0398

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Av författaren/redakt...: Gabbi, C; Warner, M; Gustafsson, JA

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