Cumulative incidence and risk factors of myocardial infarction during 20years of follow-up: comparing two cohorts of middle-aged men born 30years apart

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Fältnamn	Indikatorer	Metadata
000		04148naa a2200397 4500
001		oai:gup.ub.gu.se/332248
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:uu-518517
024	7	a https://gup.ub.gu.se/publication/3322482 URI
024	7	a https://doi.org/10.1007/s00392-023-02308-y2 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5185172 URI
040		a (SwePub)gud (SwePub)uu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Sakalaki, Maria,d 1986u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xsakam
245	1 0	a Cumulative incidence and risk factors of myocardial infarction during 20years of follow-up: comparing two cohorts of middle-aged men born 30years apart
264	1	c 2023
520		a Objective: To study cumulative incidence and predictors of myocardial infarction (MI) in two random general population samples consisting of middle-aged Swedish men born 30years apart. Method: Results from the “Study of Men Born In 1913” and the “Study of Men Born In 1943”, two longitudinal cohort studies performed in the same geographic area and using the same methodology were compared. Both cohorts were followed prospectively from 50 to 70years of age. MI was defined as first myocardial infarction, fatal or non-fatal. Results: Men born in 1943 had a 34% lower cumulative risk of first MI [HR 0.66 (0.50–0.88), p = 0.0051] during follow-up as compared to men born in 1913. Interaction analysis showed that hypertension had a significantly higher impact on risk of MI in cohort 1943 than in cohort 1913 [HR 2.33 (95% CI 1.41–3.83)] and [HR 1.10 (0.74–1.62)], p = 0.0009 respectively. The population attributable risk for hypertension was 2.5-fold higher in the cohort of men born in 1943 as compared to men born in 1913, and diabetes mellitus and sedentary lifestyle attributed more to MI risk in cohort 1943 than in cohort 1913. On the contrary, smoking and total cholesterol have less attributable risk to MI in cohort 1943 than in cohort 1913. Conclusion: Despite declining incident MI and improved cardiovascular prevention in general, hypertension remains an increasingly important attributable risk factor to MI together with diabetes mellitus and sedentary lifestyle over time.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a Ischemic heart disease
653		a Myocardial infarction
653		a Prevention
653		a Ischemic heart disease
700	1	a Pivodic, Aldina,d 1978u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xpival
700	1	a Svärdsudd, Kurt,d 1942-u Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)kurtsvar
700	1	a Hansson, Per-Olof,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xhanpm
700	1	a Fu, Michael,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xfumiw
710	2	a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org
773	0	t Clinical Research in Cardiologyx 1861-0684x 1861-0692
856	4 8	u https://gup.ub.gu.se/publication/332248
856	4 8	u https://doi.org/10.1007/s00392-023-02308-y
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-518517

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Av författaren/redakt...: Sakalaki, Maria, ...; Pivodic, Aldina, ...; Svärdsudd, Kurt, ...; Hansson, Per-Olo ...; Fu, Michael, 196 ...

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