WFRF:(Bachiller S.)
Search: WFRF:(Bachiller S.) > Early-life stress e...
- 34 of 34
- Previous record
- Next record
- To hitlist
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06492naa a2200433 4500 | |
| 001 | oai:lup.lub.lu.se:5bfb1e19-b0c8-46bb-bdeb-fcd92a1e8523 | |
| 003 | SwePub | |
| 008 | 220628s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/5bfb1e19-b0c8-46bb-bdeb-fcd92a1e85232 URI |
| 024 | 7 | a https://doi.org/10.1186/s12974-022-02515-w2 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Bachiller, S.u Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)sa2870ba |
| 245 | 1 0 | a Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner |
| 264 | c 2022-06-15 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a BackgroundThe risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing the risk of developing AD. Microglial dysfunction and neuroinflammation have been implicated as playing a role in AD pathology and may be modulated by ELS. To complicate matters further, sex-specific effects have been noted in response to ELS and in the incidence and progression of AD.MethodsHere, we subjected male and female mice with either a wild type or 5xFAD familial AD-model background to maternal separation (MS) from postnatal day 2 to 14 to induce ELS.ResultsWe detected hippocampal neuroinflammatory alterations already at postnatal day 15. By 4 months of age, MS mice presented increased immobility time in the forced swim test and a lower discrimination index in the novel object recognition memory test compared to controls. We found altered Bdnf and Arc expression in the hippocampus and increased microglial activation in the prefrontal cortex due to MS in a sex-dependent manner. In 5xFAD mice specifically, MS exacerbated amyloid-beta deposition, particularly in females. In the periphery, the immune cell population was altered by MS exposure.ConclusionOverall, our results demonstrate that MS has both short- and long-term effects on brain regions related to memory and on the inflammatory system, both in the brain and periphery. These ELS-related effects that are detectable even in adulthood may exacerbate pathology and increase the risk of developing AD via sex-specific mechanisms. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 700 | 1 | a Hidalgo, I.u Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)is7475hi |
| 700 | 1 | a Garcia, M. G.u Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Neuroinflammation,Experimental Dementia Research,Lund University Research Groups4 aut0 (Swepub:lu)me5408ga |
| 700 | 1 | a Boza-Serrano, A.u Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Seville4 aut0 (Swepub:lu)med-ab_ |
| 700 | 1 | a Paulus, A.u Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Neuroinflammation,Forskargrupper vid Lunds universitet,Medicinsk mikrospektroskopi,Other operations, LTH,Faculty of Engineering, LTH,Lund University Research Groups,Medical Microspectroscopy4 aut0 (Swepub:lu)ag5431pa |
| 700 | 1 | a Denis, Q.u Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)qu2176de |
| 700 | 1 | a Haikal, C.u Lund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Neural Plasticity and Repair,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ca6087ha |
| 700 | 1 | a Manouchehrian, O.u Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-omo |
| 700 | 1 | a Klementieva, O.u Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Medical Microspectroscopy,Lund University Research Groups,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)med-oka |
| 700 | 1 | a Li, J. Y.u Lund University,Lunds universitet,Neural plasticitet och reparation,Forskargrupper vid Lunds universitet,Neural Plasticity and Repair,Lund University Research Groups4 aut0 (Swepub:lu)mphy-jli |
| 700 | 1 | a Pronk, C. J.u Lund University,Lunds universitet,Avdelningen för molekylär hematologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Division of Molecular Hematology (DMH),Department of Laboratory Medicine,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine4 aut0 (Swepub:lu)stem-kpr |
| 700 | 1 | a Gouras, G. K.u Lund University,Lunds universitet,Experimentell demensforskning,Forskargrupper vid Lunds universitet,Experimental Dementia Research,Lund University Research Groups4 aut0 (Swepub:lu)med-grg |
| 700 | 1 | a Deierborg, T.u Lund University,Lunds universitet,Neuroinflammation,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)expb-tol |
| 710 | 2 | a Neuroinflammationb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Journal of Neuroinflammationd : Springer Science and Business Media LLCg 19q 19x 1742-2094 |
| 856 | 4 | u http://dx.doi.org/10.1186/s12974-022-02515-wx freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/5bfb1e19-b0c8-46bb-bdeb-fcd92a1e8523 |
| 856 | 4 8 | u https://doi.org/10.1186/s12974-022-02515-w |
Find in a library
- Journal of Neuroinflammation (Search for host publication in LIBRIS)
To the university's database
- 34 of 34
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bachiller, S.
- Hidalgo, I.
- Garcia, M. G.
- Boza-Serrano, A.
- Paulus, A.
- Denis, Q.
- show more...
- Haikal, C.
- Manouchehrian, O ...
- Klementieva, O.
- Li, J. Y.
- Pronk, C. J.
- Gouras, G. K.
- Deierborg, T.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- Journal of Neuro ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
