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  • Fukumoto, Noriko (author)

Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease : New data and meta-analysis

  • Article/chapterEnglish2010

Publisher, publication year, extent ...

  • Wiley,2010
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-122991
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122991URI
  • https://doi.org/10.1002/ajmg.b.30986DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Conflicting results have been reported as to whether genetic variations (Val66Met and C270T) of the brain-derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's disease (AD). We genotyped these polymorphisms in a Japanese sample of 657 patients with AD and 525 controls, and obtained weak evidence of association for Val66Met (P = 0.063), but not for C270T. After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men. To confirm these observations, we collected genotyping data for each sex from 16 research centers worldwide (4,711 patients and 4,537 controls in total). The meta-analysis revealed that there was a clear sex difference in the allelic association; the Met66 allele confers susceptibility to AD in women (odds ratio = 1.14, 95% CI 1.05-1.24, P = 0.002), but not in men. Our results provide evidence that the Met66 allele of BDNF has a sexually dimorphic effect on susceptibility to AD.

Subject headings and genre

  • Alzheimer's disease (AD)
  • brain-derived neurotrophic factor (BDNF)
  • meta-analysis
  • polymorphism
  • sex difference
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fujii, Takashi (author)
  • Combarros, Onofre (author)
  • Kamboh, M Ilyas (author)
  • Tsai, Shin-Jen (author)
  • Matsushita, Sachio (author)
  • Nacmias, Benedetta (author)
  • Comings, David E (author)
  • Arboleda, Humberto (author)
  • Ingelsson, MartinUppsala universitet,Geriatrik(Swepub:uu)maing121 (author)
  • Hyman, Bradley T (author)
  • Akatsu, Hiroyasu (author)
  • Grupe, Andrew (author)
  • Nishimura, Agnes Lumi (author)
  • Zatz, Mayana (author)
  • Mattila, Kari M (author)
  • Rinne, Juha (author)
  • Goto, Yu-ichi (author)
  • Asada, Takashi (author)
  • Nakamura, Shun (author)
  • Kunugi, Hiroshi (author)
  • Uppsala universitetGeriatrik (creator_code:org_t)

Related titles

  • In:American journal of medical genetics. Part B, Neuropsychiatric genetics: Wiley153B:1, s. 235-2421552-48411552-485X

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