Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis

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Fältnamn	Indikatorer	Metadata
000		03061naa a2200577 4500
001		oai:DiVA.org:uu-122991
003		SwePub
008		100422s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1229912 URI
024	7	a https://doi.org/10.1002/ajmg.b.309862 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fukumoto, Noriko4 aut
245	1 0	a Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease :b New data and meta-analysis
264	1	b Wiley,c 2010
338		a print2 rdacarrier
520		a Conflicting results have been reported as to whether genetic variations (Val66Met and C270T) of the brain-derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's disease (AD). We genotyped these polymorphisms in a Japanese sample of 657 patients with AD and 525 controls, and obtained weak evidence of association for Val66Met (P = 0.063), but not for C270T. After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men. To confirm these observations, we collected genotyping data for each sex from 16 research centers worldwide (4,711 patients and 4,537 controls in total). The meta-analysis revealed that there was a clear sex difference in the allelic association; the Met66 allele confers susceptibility to AD in women (odds ratio = 1.14, 95% CI 1.05-1.24, P = 0.002), but not in men. Our results provide evidence that the Met66 allele of BDNF has a sexually dimorphic effect on susceptibility to AD.
653		a Alzheimer's disease (AD)
653		a brain-derived neurotrophic factor (BDNF)
653		a meta-analysis
653		a polymorphism
653		a sex difference
653		a MEDICINE
653		a MEDICIN
700	1	a Fujii, Takashi4 aut
700	1	a Combarros, Onofre4 aut
700	1	a Kamboh, M Ilyas4 aut
700	1	a Tsai, Shin-Jen4 aut
700	1	a Matsushita, Sachio4 aut
700	1	a Nacmias, Benedetta4 aut
700	1	a Comings, David E4 aut
700	1	a Arboleda, Humberto4 aut
700	1	a Ingelsson, Martinu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)maing121
700	1	a Hyman, Bradley T4 aut
700	1	a Akatsu, Hiroyasu4 aut
700	1	a Grupe, Andrew4 aut
700	1	a Nishimura, Agnes Lumi4 aut
700	1	a Zatz, Mayana4 aut
700	1	a Mattila, Kari M4 aut
700	1	a Rinne, Juha4 aut
700	1	a Goto, Yu-ichi4 aut
700	1	a Asada, Takashi4 aut
700	1	a Nakamura, Shun4 aut
700	1	a Kunugi, Hiroshi4 aut
710	2	a Uppsala universitetb Geriatrik4 org
773	0	t American journal of medical genetics. Part B, Neuropsychiatric geneticsd : Wileyg 153B:1, s. 235-242q 153B:1<235-242x 1552-4841x 1552-485X
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122991
856	4 8	u https://doi.org/10.1002/ajmg.b.30986

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