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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06268naa a2201777 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:236789420 | |
| 003 | SwePub | |
| 008 | 240916s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2367894202 URI |
| 024 | 7 | a https://doi.org/10.1101/2023.01.19.232847372 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Thomas, M4 aut |
| 245 | 1 0 | a Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity |
| 264 | 1 | b Cold Spring Harbor Laboratory,c 2023 |
| 520 | a Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations. Towards addressing this deficiency, we expanded PRS development for CRC by incorporating Asian ancestry data (21,731 cases; 47,444 controls) into European ancestry training datasets (78,473 cases; 107,143 controls). The AUC estimates (95% CI) of PRS were 0.63(0.62-0.64), 0.59(0.57-0.61), 0.62(0.60-0.63), and 0.65(0.63-0.66) in independent datasets including 1,681-3,651 cases and 8,696-115,105 controls of Asian, Black/African American, Latinx/Hispanic, and non-Hispanic White, respectively. They were significantly better than the European-centric PRS in all four major US racial and ethnic groups (p-values<0.05). Further inclusion of non-European ancestry populations, especially Black/African American and Latinx/Hispanic, is needed to improve the risk prediction and enhance equity in applying PRS in clinical practice. | |
| 700 | 1 | a Su, YR4 aut |
| 700 | 1 | a Rosenthal, EA4 aut |
| 700 | 1 | a Sakoda, LC4 aut |
| 700 | 1 | a Schmit, SL4 aut |
| 700 | 1 | a Timofeeva, MN4 aut |
| 700 | 1 | a Chen, Z4 aut |
| 700 | 1 | a Fernandez-Rozadilla, C4 aut |
| 700 | 1 | a Law, PJ4 aut |
| 700 | 1 | a Murphy, N4 aut |
| 700 | 1 | a Carreras-Torres, R4 aut |
| 700 | 1 | a Diez-Obrero, V4 aut |
| 700 | 1 | a van Duijnhoven, FJ4 aut |
| 700 | 1 | a Jiang, S4 aut |
| 700 | 1 | a Shin, A4 aut |
| 700 | 1 | a Wolk, Au Karolinska Institutet4 aut |
| 700 | 1 | a Phipps, AI4 aut |
| 700 | 1 | a Burnett-Hartman, A4 aut |
| 700 | 1 | a Gsur, A4 aut |
| 700 | 1 | a Chan, AT4 aut |
| 700 | 1 | a Zauber, AG4 aut |
| 700 | 1 | a Wu, AH4 aut |
| 700 | 1 | a Lindblom, A4 aut |
| 700 | 1 | a Um, CY4 aut |
| 700 | 1 | a Tangen, CM4 aut |
| 700 | 1 | a Gignoux, C4 aut |
| 700 | 1 | a Newton, C4 aut |
| 700 | 1 | a Haiman, CA4 aut |
| 700 | 1 | a Qu, C4 aut |
| 700 | 1 | a Bishop, DT4 aut |
| 700 | 1 | a Buchanan, DD4 aut |
| 700 | 1 | a Crosslin, DR4 aut |
| 700 | 1 | a Conti, DV4 aut |
| 700 | 1 | a Kim, DH4 aut |
| 700 | 1 | a Hauser, E4 aut |
| 700 | 1 | a White, E4 aut |
| 700 | 1 | a Siegel, E4 aut |
| 700 | 1 | a Schumacher, FR4 aut |
| 700 | 1 | a Rennert, G4 aut |
| 700 | 1 | a Giles, GG4 aut |
| 700 | 1 | a Hampel, H4 aut |
| 700 | 1 | a Brenner, H4 aut |
| 700 | 1 | a Oze, I4 aut |
| 700 | 1 | a Oh, JH4 aut |
| 700 | 1 | a Lee, JK4 aut |
| 700 | 1 | a Schneider, JL4 aut |
| 700 | 1 | a Chang-Claude, J4 aut |
| 700 | 1 | a Kim, J4 aut |
| 700 | 1 | a Huyghe, JR4 aut |
| 700 | 1 | a Zheng, J4 aut |
| 700 | 1 | a Hampe, J4 aut |
| 700 | 1 | a Greenson, J4 aut |
| 700 | 1 | a Hopper, JL4 aut |
| 700 | 1 | a Palmer, JR4 aut |
| 700 | 1 | a Visvanathan, K4 aut |
| 700 | 1 | a Matsuo, K4 aut |
| 700 | 1 | a Matsuda, K4 aut |
| 700 | 1 | a Jung, KJ4 aut |
| 700 | 1 | a Li, L4 aut |
| 700 | 1 | a Marchand, LL4 aut |
| 700 | 1 | a Vodickova, L4 aut |
| 700 | 1 | a Bujanda, L4 aut |
| 700 | 1 | a Gunter, MJ4 aut |
| 700 | 1 | a Matejcic, M4 aut |
| 700 | 1 | a Jenkins, MA4 aut |
| 700 | 1 | a Slattery, ML4 aut |
| 700 | 1 | a D'Amato, M4 aut |
| 700 | 1 | a Wang, M4 aut |
| 700 | 1 | a Hoffmeister, M4 aut |
| 700 | 1 | a Woods, MO4 aut |
| 700 | 1 | a Kim, M4 aut |
| 700 | 1 | a Song, M4 aut |
| 700 | 1 | a Iwasaki, M4 aut |
| 700 | 1 | a Du, M4 aut |
| 700 | 1 | a Udaltsova, N4 aut |
| 700 | 1 | a Sawada, N4 aut |
| 700 | 1 | a Vodicka, P4 aut |
| 700 | 1 | a Campbell, PT4 aut |
| 700 | 1 | a Newcomb, PA4 aut |
| 700 | 1 | a Cai, Q4 aut |
| 700 | 1 | a Pearlman, R4 aut |
| 700 | 1 | a Pai, RK4 aut |
| 700 | 1 | a Schoen, RE4 aut |
| 700 | 1 | a Steinfelder, RS4 aut |
| 700 | 1 | a Haile, RW4 aut |
| 700 | 1 | a Vandenputtelaar, R4 aut |
| 700 | 1 | a Prentice, RL4 aut |
| 700 | 1 | a Küry, S4 aut |
| 700 | 1 | a Castellví-Bel, S4 aut |
| 700 | 1 | a Tsugane, S4 aut |
| 700 | 1 | a Berndt, SI4 aut |
| 700 | 1 | a Lee, SC4 aut |
| 700 | 1 | a Brezina, S4 aut |
| 700 | 1 | a Weinstein, SJ4 aut |
| 700 | 1 | a Chanock, SJ4 aut |
| 700 | 1 | a Jee, SH4 aut |
| 700 | 1 | a Kweon, SS4 aut |
| 700 | 1 | a Vadaparampil, S4 aut |
| 700 | 1 | a Harrison, TA4 aut |
| 700 | 1 | a Yamaji, T4 aut |
| 700 | 1 | a Keku, TO4 aut |
| 700 | 1 | a Vymetalkova, V4 aut |
| 700 | 1 | a Arndt, V4 aut |
| 700 | 1 | a Jia, WH4 aut |
| 700 | 1 | a Shu, XO4 aut |
| 700 | 1 | a Lin, Y4 aut |
| 700 | 1 | a Ahn, YO4 aut |
| 700 | 1 | a Stadler, ZK4 aut |
| 700 | 1 | a Van Guelpen, B4 aut |
| 700 | 1 | a Ulrich, CM4 aut |
| 700 | 1 | a Platz, EA4 aut |
| 700 | 1 | a Potter, JD4 aut |
| 700 | 1 | a Li, CI4 aut |
| 700 | 1 | a Meester, R4 aut |
| 700 | 1 | a Moreno, V4 aut |
| 700 | 1 | a Figueiredo, JC4 aut |
| 700 | 1 | a Casey, G4 aut |
| 700 | 1 | a Vogelaar, IL4 aut |
| 700 | 1 | a Dunlop, MG4 aut |
| 700 | 1 | a Gruber, SB4 aut |
| 700 | 1 | a Hayes, RB4 aut |
| 700 | 1 | a Pharoah, PDP4 aut |
| 700 | 1 | a Houlston, RS4 aut |
| 700 | 1 | a Jarvik, GP4 aut |
| 700 | 1 | a Tomlinson, IP4 aut |
| 700 | 1 | a Zheng, W4 aut |
| 700 | 1 | a Corley, DA4 aut |
| 700 | 1 | a Peters, U4 aut |
| 700 | 1 | a Hsu, L4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t medRxiv : the preprint server for health sciencesd : Cold Spring Harbor Laboratory |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236789420 |
| 856 | 4 8 | u https://doi.org/10.1101/2023.01.19.23284737 |
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